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Table 2 The degrees of gene and the expression fold change of proteins in each significant KEGG pathway (pathway enriched FDR < 0.05)

From: Revealing the pathogenic changes of PAH based on multiomics characteristics

KEGG-pathway Gene symbol Name Degree FC
ECM-receptor interaction Itga5 Integrin subunit alpha 5 11 0.79
Spp1 Secreted phosphoprotein 1 8 1.32
Vtn Vitronectin 7 1.28
Thbs4 Thrombospondin 4 6 1.26
Col4a1 Collagen, type IV, alpha 1 6 1.88
Lamb1 Laminin, beta 1 5 1.31
Col4a6 Collagen, type IV, alpha 6 5 0.78
Col2a1 Collagen, type II, alpha 1 5 0.58
Fn1 Fibronectin 1 4 1.27
Tnc Tenascin C 3 1.49
Col6a6 Collagen, type VI, alpha 6 1 0.72
Col6a5 Collagen, type VI, alpha 5 1 0.69
Focal adhesion Itga5 Integrin subunit alpha 5 12 0.79
Spp1 Secreted phosphoprotein 1 10 1.32
Vtn Vitronectin 9 1.28
Cav1 Caveolin 1 7 0.73
Mapk10 Mitogen activated protein kinase 10 7 0.63
Col2a1 Collagen, type II, alpha 1 6 0.58
Col4a1 Collagen, type IV, alpha 1 6 1.88
Flnc Filamin C, gamma 6 0.75
Fn1 Fibronectin 1 6 1.27
Lamb1 Laminin, beta 1 6 1.31
Thbs4 Thrombospondin 4 6 1.26
Tnc Tenascin C 6 1.49
Col4a6 Collagen, type IV, alpha 6 5 0.78
Myl10 Myosin, light chain 10, regulatory 2 0.77
Cav2 Caveolin 2 1 0.76
Col6a5 Collagen, type VI, alpha 5 1 0.69
Col6a6 Collagen, type VI, alpha 6 1 0.72
Ppp1cc Protein phosphatase 1 catalytic subunit gamma 1 0.72
Drug metabolism-cytochrome P450 Gstm2 Glutathione S-transferase mu 2 9 0.73
Gstt1 Glutathione S-transferase theta 1 9 0.80
Adh1c Alcohol dehydrogenase 1C (class I) 8 0.78
Gstm3 Glutathione S-transferase mu 3 8 0.59
Mgst2 Microsomal glutathione S-transferase 2 8 1.50
Adh5 Alcohol dehydrogenase 5 (class III) 7 0.78
Aldh3a1 Aldehyde dehydrogenase 3 family, member A1 7 0.72
Aox3 Aldehyde oxidase 3 0 0.73
Gsta4 Glutathione S-transferase alpha 4 7 0.76
Gsta3 Glutathione S-transferase alpha 3 5 0.64
Aox1 Aldehyde oxidase 1 2 0.73
Gstm5 Glutathione S-transferase, mu 5 2 0.67
Fmo5 Flavin containing monooxygenase 5 0 1.27
Metabolism of xenobiotics by cytochrome P450 Gstm2 Glutathione S-transferase mu 2 10 0.73
Gstt1 Glutathione S-transferase theta 1 10 0.80
Ephx1 Epoxide hydrolase 1 9 0.69
Gstm3 Glutathione S-transferase mu 3 9 0.59
Mgst2 Microsomal glutathione S-transferase 2 9 1.50
Adh1c Alcohol dehydrogenase 1C (class I) 8 0.78
Aldh3a1 Aldehyde dehydrogenase 3 family, member A1 8 0.72
Gsta4 Glutathione S-transferase alpha 4 8 0.76
Adh5 Alcohol dehydrogenase 5 (class III) 6 0.78
Gsta3 Glutathione S-transferase alpha 3 6 0.64
Gstm5 Glutathione S-transferase, mu 5 3 0.67
Complement and coagulation cascades C3 Complement C3 16 1.26
Fgg Fibrinogen gamma chain 14 1.57
Fga Fibrinogen alpha chain 12 1.60
Kng1 Kininogen 1 12 3.01
F10 Coagulation factor X 11 1.32
Fgb Fibrinogen beta chain 10 1.49
Kng2 Kininogen 2 10 1.80
Proc Protein C 10 0.79
C9 Complement component 9 9 1.44
F3 Coagulation factor III 9 0.71
C4bpa Complement component 4 binding protein, alpha 7 1.64
C4bpb Complement component 4 binding protein, beta 7 1.90
Thbd Thrombomodulin 6 0.62
C1qb Complement C1q B chain 5 1.25
C5 Complement component 5 4 1.29
C5ar1 Complement C5a receptor 1 4 1.47
F13a1 Coagulation factor XIII A1 chain 4 1.27
A2m Alpha-2-macroglobulin 3 1.93
C6 Complement component 6 3 1.31
Kng2l1 Kininogen 2-like 1 0 1.55
  1. The KEGG pathway name, gene symbol, gene name, the degree of gene in the PPI network and the FC of proteins are shown. These genes validated subsequently, are highlighted in italic