Table 2 The degrees of gene and the expression fold change of proteins in each significant KEGG pathway (pathway enriched FDR < 0.05)
From: Revealing the pathogenic changes of PAH based on multiomics characteristics
KEGG-pathway | Gene symbol | Name | Degree | FC |
|---|---|---|---|---|
ECM-receptor interaction | Itga5 | Integrin subunit alpha 5 | 11 | 0.79 |
Spp1 | Secreted phosphoprotein 1 | 8 | 1.32 | |
Vtn | Vitronectin | 7 | 1.28 | |
Thbs4 | Thrombospondin 4 | 6 | 1.26 | |
Col4a1 | Collagen, type IV, alpha 1 | 6 | 1.88 | |
Lamb1 | Laminin, beta 1 | 5 | 1.31 | |
Col4a6 | Collagen, type IV, alpha 6 | 5 | 0.78 | |
Col2a1 | Collagen, type II, alpha 1 | 5 | 0.58 | |
Fn1 | Fibronectin 1 | 4 | 1.27 | |
Tnc | Tenascin C | 3 | 1.49 | |
Col6a6 | Collagen, type VI, alpha 6 | 1 | 0.72 | |
Col6a5 | Collagen, type VI, alpha 5 | 1 | 0.69 | |
Focal adhesion | Itga5 | Integrin subunit alpha 5 | 12 | 0.79 |
Spp1 | Secreted phosphoprotein 1 | 10 | 1.32 | |
Vtn | Vitronectin | 9 | 1.28 | |
Cav1 | Caveolin 1 | 7 | 0.73 | |
Mapk10 | Mitogen activated protein kinase 10 | 7 | 0.63 | |
Col2a1 | Collagen, type II, alpha 1 | 6 | 0.58 | |
Col4a1 | Collagen, type IV, alpha 1 | 6 | 1.88 | |
Flnc | Filamin C, gamma | 6 | 0.75 | |
Fn1 | Fibronectin 1 | 6 | 1.27 | |
Lamb1 | Laminin, beta 1 | 6 | 1.31 | |
Thbs4 | Thrombospondin 4 | 6 | 1.26 | |
Tnc | Tenascin C | 6 | 1.49 | |
Col4a6 | Collagen, type IV, alpha 6 | 5 | 0.78 | |
Myl10 | Myosin, light chain 10, regulatory | 2 | 0.77 | |
Cav2 | Caveolin 2 | 1 | 0.76 | |
Col6a5 | Collagen, type VI, alpha 5 | 1 | 0.69 | |
Col6a6 | Collagen, type VI, alpha 6 | 1 | 0.72 | |
Ppp1cc | Protein phosphatase 1 catalytic subunit gamma | 1 | 0.72 | |
Drug metabolism-cytochrome P450 | Gstm2 | Glutathione S-transferase mu 2 | 9 | 0.73 |
Gstt1 | Glutathione S-transferase theta 1 | 9 | 0.80 | |
Adh1c | Alcohol dehydrogenase 1C (class I) | 8 | 0.78 | |
Gstm3 | Glutathione S-transferase mu 3 | 8 | 0.59 | |
Mgst2 | Microsomal glutathione S-transferase 2 | 8 | 1.50 | |
Adh5 | Alcohol dehydrogenase 5 (class III) | 7 | 0.78 | |
Aldh3a1 | Aldehyde dehydrogenase 3 family, member A1 | 7 | 0.72 | |
Aox3 | Aldehyde oxidase 3 | 0 | 0.73 | |
Gsta4 | Glutathione S-transferase alpha 4 | 7 | 0.76 | |
Gsta3 | Glutathione S-transferase alpha 3 | 5 | 0.64 | |
Aox1 | Aldehyde oxidase 1 | 2 | 0.73 | |
Gstm5 | Glutathione S-transferase, mu 5 | 2 | 0.67 | |
Fmo5 | Flavin containing monooxygenase 5 | 0 | 1.27 | |
Metabolism of xenobiotics by cytochrome P450 | Gstm2 | Glutathione S-transferase mu 2 | 10 | 0.73 |
Gstt1 | Glutathione S-transferase theta 1 | 10 | 0.80 | |
Ephx1 | Epoxide hydrolase 1 | 9 | 0.69 | |
Gstm3 | Glutathione S-transferase mu 3 | 9 | 0.59 | |
Mgst2 | Microsomal glutathione S-transferase 2 | 9 | 1.50 | |
Adh1c | Alcohol dehydrogenase 1C (class I) | 8 | 0.78 | |
Aldh3a1 | Aldehyde dehydrogenase 3 family, member A1 | 8 | 0.72 | |
Gsta4 | Glutathione S-transferase alpha 4 | 8 | 0.76 | |
Adh5 | Alcohol dehydrogenase 5 (class III) | 6 | 0.78 | |
Gsta3 | Glutathione S-transferase alpha 3 | 6 | 0.64 | |
Gstm5 | Glutathione S-transferase, mu 5 | 3 | 0.67 | |
Complement and coagulation cascades | C3 | Complement C3 | 16 | 1.26 |
Fgg | Fibrinogen gamma chain | 14 | 1.57 | |
Fga | Fibrinogen alpha chain | 12 | 1.60 | |
Kng1 | Kininogen 1 | 12 | 3.01 | |
F10 | Coagulation factor X | 11 | 1.32 | |
Fgb | Fibrinogen beta chain | 10 | 1.49 | |
Kng2 | Kininogen 2 | 10 | 1.80 | |
Proc | Protein C | 10 | 0.79 | |
C9 | Complement component 9 | 9 | 1.44 | |
F3 | Coagulation factor III | 9 | 0.71 | |
C4bpa | Complement component 4 binding protein, alpha | 7 | 1.64 | |
C4bpb | Complement component 4 binding protein, beta | 7 | 1.90 | |
Thbd | Thrombomodulin | 6 | 0.62 | |
C1qb | Complement C1q B chain | 5 | 1.25 | |
C5 | Complement component 5 | 4 | 1.29 | |
C5ar1 | Complement C5a receptor 1 | 4 | 1.47 | |
F13a1 | Coagulation factor XIII A1 chain | 4 | 1.27 | |
A2m | Alpha-2-macroglobulin | 3 | 1.93 | |
C6 | Complement component 6 | 3 | 1.31 | |
Kng2l1 | Kininogen 2-like 1 | 0 | 1.55 |