Table 1 Top regulated proteins: integrate analysis of three-omics
From: Revealing the pathogenic changes of PAH based on multiomics characteristics
Correlation | Methylation information | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Gene symbol | mRNA_ID | Protein full name | FC | dir | p | FDR | Chr | Info1 | Info2 | Info3 |
S100a9 | ENSRNOT00000015351 | Protein S100-A9 | 5.8 | Up | 1.2E−04 | 1.9E−02 | chr2 | Intron | First intron | NA |
Ttc29 | ENSRNOT00000089569 | Tetratricopeptide repeat protein 29 | 0.3 | Down | 7.9E−05 | 8.8E−03 | chr19 | Exon | Internal exon | NA |
Bicc1 | MSTRG.12240.6 | BicC family RNA-binding protein 1 | 5.2 | Up | 5.0E−04 | 4.5E−02 | chr20 | Intron | Internal intron | NA |
Tnc | ENSRNOT00000084563 | Tenascin C | 0.0 | Down | 7.1E−07 | 1.6E−04 | chr5 | Intron | Internal intron | NA |
Runx1 | MSTRG.4485.1 | Runt-related transcription factor 1 | 0.6 | Down | 5.4E−05 | 8.5E−03 | chr11 | Intron | First intron | NA |
Picalm | ENSRNOT00000092945 | Clathrin-assembly lymphoid myeloid leukemia protein | 8.7 | Up | 2.1E−13 | 1.4E−10 | chr1 | Intron | Internal intron | NA |
Cdyl2 | ENSRNOT00000068440 | Chromodomain Y-like 2 | 0.3 | Down | 1.4E−04 | 1.4E−02 | chr19 | Intron | Internal intron | NA |
Gfpt2 | ENSRNOT00000003770 | Glutamine-fructose-6-phosphate aminotransferase 2 | 0.8 | Down | 3.9E−05 | 5.1E−03 | chr10 | Intron | Internal intron | NA |
Folr2 | MSTRG.1446.1 | Folate receptor 2 | 0.2 | Down | 8.7E−05 | 1.2E−02 | chr1 | Promoter | Distal | LCP |
Slc43a2 | MSTRG.3515.3 | Solute carrier family 43 member 2 | 17.7 | Up | 2.2E−19 | 3.0E−16 | chr10 | Intron | Internal intron | NA |
Myh6 | ENSRNOT00000023302 | Myosin-6 | 2.8 | Up | 4.8E−05 | 8.6E−03 | chr15 | Intron | Internal intron | NA |
RGD1563354 | ENSRNOT00000019453 | Similar to hypothetical protein D630003M21 | 0.2 | Down | 5.6E−06 | 1.1E−03 | chr3 | Promoter | Distal | LCP |
Hist2h2ac | ENSRNOT00000051917 | Histone H2A | 0.2 | down | 9.0E−08 | 3.0E−05 | chr2 | Promoter | Intermediate | ICP |
Map4k2 | ENSRNOT00000064798 | Mitogen-activated protein kinase | 4.9 | up | 3.4E−06 | 6.8E−04 | chr1 | Intron | Internal intron | NA |
Gsta3 | ENSRNOT00000088416 | Glutathione S-transferase alpha-3 | 2.7 | up | 2.3E−04 | 9.2E−06 | chr9 | Exon | Last exon | NA |
Pdk4 | ENSRNOT00000012760 | Pyruvate dehydrogenase kinase, isoenzyme 4 | 0.2 | down | 7.9E−09 | 2.7E−06 | chr4 | Promoter | Proximal | LCP |
Med12 l | ENSRNOT00000084020 | Mediator complex subunit 12-like | 6.5 | Up | 1.3E−08 | 5.0E−06 | chr2 | Promoter | Distal | LCP |
Mapk10 | ENSRNOT00000065965 | Mitogen-activated protein kinase | 2.6 | Up | 3.6E−06 | 8.0E−04 | chr14 | Intron | First intron | NA |
Cd63 | ENSRNOT00000090381 | Ad1-antigen | 0.5 | Down | 3.6E−06 | 7.0E−04 | chr7 | Promoter | Intermediate | ICP |
Krt1 | ENSRNOT00000034450 | Keratin, type II cytoskeletal 1 | 21.8 | Up | 3.6E−04 | 3.9E−02 | chr7 | Promoter | Distal | LCP |
Correlation | mRNA information | Protein information | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Gene symbol | mRNA_ID | Protein full name | FC | dir | p | FDR | FC | dir | p | FDR |
S100a9 | ENSRNOT00000015351 | Protein S100-A9 | 2.4 | Up | 0.05 | 0.82 | 1.6 | Up | 6.6E−11 | 4.5E−10 |
Ttc29 | ENSRNOT00000089569 | Tetratricopeptide repeat protein 29 | 1.0 | Down | 0.22 | 0.84 | 1.5 | Up | 1.9E−10 | 1.2E−09 |
Bicc1 | MSTRG.12240.6 | BicC family RNA-binding protein 1 | 0.8 | Down | 0.38 | 0.84 | 1.5 | Up | 1.2E−05 | 2.8E−05 |
Tnc | ENSRNOT00000084563 | Tenascin C | 2.2 | Up | 0.36 | 0.84 | 1.5 | Up | 1.5E−12 | 1.5E−11 |
Runx1 | MSTRG.4485.1 | Runt-related transcription factor 1 | 1.5 | Up | 0.3 | 0.84 | 1.5 | Up | 3.2E−10 | 1.9E−09 |
Picalm | ENSRNOT00000092945 | Clathrin-assembly lymphoid myeloid leukemia protein | 0.6 | Down | 0.04 | 0.82 | 1.5 | Up | 1.6E−10 | 1.0E−09 |
Cdyl2 | ENSRNOT00000068440 | Chromodomain Y-like 2 | 1.1 | Up | 0.24 | 0.84 | 1.4 | Up | 9.9E−16 | 2.7E−14 |
Gfpt2 | ENSRNOT00000003770 | Glutamine-fructose-6-phosphate aminotransferase 2 | 1.5 | Up | 0.1 | 0.82 | 1.4 | Up | 1.7E−17 | 9.4E−16 |
Folr2 | MSTRG.1446.1 | Folate receptor 2 | 1.4 | Up | 0.15 | 0.84 | 1.4 | Up | 6.4E−18 | 4.3E−16 |
Slc43a2 | MSTRG.3515.3 | Solute carrier family 43 member 2 | 1.7 | Up | 0.35 | 0.84 | 1.4 | Up | 5.1E−08 | 1.9E−07 |
Myh6 | ENSRNOT00000023302 | Myosin-6 | 1.0 | Down | 0.31 | 0.84 | 0.7 | Down | 6.8E−16 | 2.0E−14 |
RGD1563354 | ENSRNOT00000019453 | Similar to hypothetical protein D630003M21 | 1.7 | Up | 0.06 | 0.82 | 0.7 | Down | 1.6E−11 | 1.2E−10 |
Hist2h2ac | ENSRNOT00000051917 | Histone H2A | 1.1 | Up | 0.51 | 0.84 | 0.7 | Down | 8.6E−07 | 2.6E−06 |
Map4k2 | ENSRNOT00000064798 | Mitogen-activated protein kinase | 1.3 | Up | 0.08 | 0.82 | 0.6 | Down | 2.4E−14 | 4.2E−13 |
Gsta3 | ENSRNOT00000088416 | Glutathione S-transferase alpha-3 | 0.8 | Down | 0.31 | 0.84 | 0.6 | Down | 2.9E−15 | 6.6E−14 |
Pdk4 | ENSRNOT00000012760 | Pyruvate dehydrogenase kinase, isoenzyme 4 | 0.3 | Down | 0.05 | 0.82 | 0.6 | Down | 5.5E−19 | 5.8E−17 |
Med12 l | ENSRNOT00000084020 | Mediator complex subunit 12-like | 1.0 | Down | 0.02 | 0.82 | 0.6 | Down | 2.2E−04 | 4.4E−04 |
Mapk10 | ENSRNOT00000065965 | Mitogen-activated protein kinase | 1.0 | Down | 0.41 | 0.84 | 0.6 | Down | 6.7E−04 | 1.2E−03 |
Cd63 | ENSRNOT00000090381 | Ad1-antigen | 1.3 | Up | 0.47 | 0.84 | 0.6 | Down | 4.8E−03 | 7.7E−03 |
Krt1 | ENSRNOT00000034450 | Keratin, type II cytoskeletal 1 | 0.7 | Down | 0.02 | 0.82 | 0.4 | Down | 4.2E−17 | 1.9E−15 |