Fig. 4

The multiomics information of the selected KEGG pathways. The means of the gene and protein expression levels from the hypoxic and control groups were compared. The data ≥ 0 in the heatmap (slant yellow and red) were upregulated, whereas data < 0 in the heatmap (partial red) were downregulated. Meanwhile, the methylation information, including methylation position, positive or negative chain, and the regulation of methylation are shown to the right of each graph. a–e represent complement and coagulation cascades, drug metabolism-cytochrome P450, metabolism of xenobiotics by cytochrome P450, ECM-receptor interaction and focal adhesion, respectively