| |
CON (n = 4)
|
D-CON (n = 4)
|
PRE (n = 4)
|
POST (n = 4)
|
|---|
|
Fmax (kN/m2)
|
16.1 ± 1.98
|
14 ± 3.47
|
14.49 ± 2.28
|
12.92 ± 0.98
|
|
Fpassive (kN/m2)
|
1.08 ± 0.19
|
0.76 ± 0.14
|
1.26 ± 0.33
|
0.97 ± 0.14
|
|
pCa
50
|
5.81 ± 0.02
|
5.77 ± 0.03
|
5.83 ± 0.02
|
5.78 ± 0.04
|
|
ktr,max (1/s)
|
4.41 ± 0.26+§^
|
2.16 ± 0.2*
|
2.63 ± 0.42*
|
2.04 ± 0.08*
|
|
nHill
|
2.63 ± 0.21
|
2.56 ± 0.09
|
2.44 ± 0.14
|
2.47 ± 0.13
|
- Fmax maximum Ca2+-activated active force, Fpassive Ca2+-independent passive force, pCa50 Ca2+-sensitivity of isometric-force production, ktr,max rate constant of force redevelopment, nHill steepness of the force-pCa curve characterising the cooperativity between myofilament units, n number of animals per group (2–4 cardiomyocytes per animal)
- * p ≤ 0.05 vs. CON; + p ≤ 0.05 vs. D-CON; § p ≤ 0.05 vs. PRE; ^ p ≤ 0.05 vs. POST
