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Table 3 Contractile parameters of isolated cardiomyocytes

From: Advantages of prophylactic versus conventionally scheduled heart failure therapy in an experimental model of doxorubicin-induced cardiomyopathy

  CON (n = 4) D-CON (n = 4) PRE (n = 4) POST (n = 4)
Fmax (kN/m2) 16.1 ± 1.98 14 ± 3.47 14.49 ± 2.28 12.92 ± 0.98
Fpassive (kN/m2) 1.08 ± 0.19 0.76 ± 0.14 1.26 ± 0.33 0.97 ± 0.14
pCa 50 5.81 ± 0.02 5.77 ± 0.03 5.83 ± 0.02 5.78 ± 0.04
ktr,max (1/s) 4.41 ± 0.26+§^ 2.16 ± 0.2* 2.63 ± 0.42* 2.04 ± 0.08*
nHill 2.63 ± 0.21 2.56 ± 0.09 2.44 ± 0.14 2.47 ± 0.13
  1. Fmax maximum Ca2+-activated active force, Fpassive Ca2+-independent passive force, pCa50 Ca2+-sensitivity of isometric-force production, ktr,max rate constant of force redevelopment, nHill steepness of the force-pCa curve characterising the cooperativity between myofilament units, n number of animals per group (2–4 cardiomyocytes per animal)
  2. * p ≤ 0.05 vs. CON; + p ≤ 0.05 vs. D-CON; § p ≤ 0.05 vs. PRE; ^ p ≤ 0.05 vs. POST