Advantages of prophylactic versus conventionally scheduled heart failure therapy in an experimental model of doxorubicin-induced cardiomyopathy

Table 3 Contractile parameters of isolated cardiomyocytes

	CON (n = 4)	D-CON (n = 4)	PRE (n = 4)	POST (n = 4)
F_max (kN/m²)	16.1 ± 1.98	14 ± 3.47	14.49 ± 2.28	12.92 ± 0.98
F_passive (kN/m²)	1.08 ± 0.19	0.76 ± 0.14	1.26 ± 0.33	0.97 ± 0.14
pCa ₅₀	5.81 ± 0.02	5.77 ± 0.03	5.83 ± 0.02	5.78 ± 0.04
k_tr,max (1/s)	4.41 ± 0.26^{+§^}	2.16 ± 0.2*	2.63 ± 0.42*	2.04 ± 0.08*
nHill	2.63 ± 0.21	2.56 ± 0.09	2.44 ± 0.14	2.47 ± 0.13

F_max maximum Ca²⁺-activated active force, F_passive Ca²⁺-independent passive force, pCa₅₀ Ca²⁺-sensitivity of isometric-force production, k_tr,max rate constant of force redevelopment, nHill steepness of the force-pCa curve characterising the cooperativity between myofilament units, n number of animals per group (2–4 cardiomyocytes per animal)
* p ≤ 0.05 vs. CON; ⁺ p ≤ 0.05 vs. D-CON; ^§ p ≤ 0.05 vs. PRE; ^{^} p ≤ 0.05 vs. POST

ISSN: 1479-5876