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Table 1 The absolute cell number of CD4+ T cell subsets calculated based on flow cytometry analysis of lymph nodes and spleen of RagKO mice reconstituted with CD4+GFPT cells and maintained on control or SM16 diet for 21 days

From: Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4+CD25+Foxp3+ and CD4+CD25Foxp3+ T cells

  Absolute cell number per mouse (105)
Lymph node Spleen
Treatment Control (%) SM16 (%) Control (%) SM16 (%)
Total cell recovery
 All CD4+ 1.18 ± 0.5 13.5 ± 1.4 21.7 ± 0.05 88.8 ± 1.90
 CD4+ CD25+ Foxp3+ (Treg) 0.1 ± 0.06 (1.4) 0.4 ± 0.03* (3.6) 0.4 ± 0.2 (3.7) 2.5 ± 1.03a (3.8)
 CD4+ CD25+ Foxp3 (activated T cell) 0.08 ± 0.04 (8.3) 0.7 ± 0.04# (6.4) 1.6 ± 1.3 (3.9) 2.5 ± 0.7b (2.7)
 CD4+ CD25 Foxp3 (other) 1.0 ± 0.5 (91.3) 12.4 ± 6.3& (90.0) 19.7 ± 0.01 (94.0) 83.8 ± 0.01c (93.5)
  1. Absolute numbers (AN) are presented as the mean trait value ± SEM. The % was determined based on average of ANs from 4 independent experiments
  2. *p value ≤ 0.05, as compared to RagkO on control diet
  3. #p value ≤ 0.05, as compared to RagkO on control diet
  4. &p value ≤ 0.05, as compared to RagkO on control diet
  5. ap value ≤ 0.05, as compared to RagkO on control diet
  6. bp value ≤ 0.05, as compared to RagkO on control diet
  7. cp value ≤ 0.05, as compared to RagkO on control diet