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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4+CD25+Foxp3+ and CD4+CD25Foxp3+ T cells

Fig. 1

FACS data of CD4+CD25 or CD4+CD25FoxP3 T cells from spleen of BALB/c and FoxP3eGFP mice. Cells were treated in vitro for 72 h with CD3/CD28 antibodies as described in the “Methods” section. Plots show CD25-PE on the y-axis and FoxP3-APC or FoxP3eGFP on the x-axis. Quadrant statistics noted are percent of live CD4+ gate. ad Mean values of % CD4+CD25+Foxp3+ from 5 independent experiments show SM16 effects on TGF-β-induced Treg conversion (e). Significance between control and experimental groups were determined by Student’s t-test (*, P < 0.05)

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