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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Identification of novel inhibitors for TNFα, TNFR1 and TNFα-TNFR1 complex using pharmacophore-based approaches

Fig. 3

The pharmacophore features of TNF-α, TNFR1 and the TNF-α–TNFR1 complex. a The TNF-α pharmacophore contained six pharmacophoric features with default ligand (307), three aromatic spheres (pink), two hydrophobic spheres (green) and HBA (orange). b The TNFR1 pharmacophore contained five pharmacophoric features with Physcion-8-glucoside, one hydrophobic (green), two aromatic (pink), one HBA (yellow), HBD (white) features. c The TNF-α–TNFR1 complex pharmacophore contained five pharmacophoric features with Erythrosine B, one hydrophobic (green), two aromatic (pink), one HBA (yellow), HBD (white) features

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