Skip to main content

Table 1 Baseline characteristics of patients with AIS and healthy control

From: Proteomic profiling of plasma biomarkers in acute ischemic stroke due to large vessel occlusion

Demographic and clinical characteristics of the study groups Proteomics Western Blots
Healthy controls (n = 20) Patients with AIS (n = 40) P value Healthy controls (n = 33) Patients with AIS (n = 66) P value Patients with AIS due to non-LVO (n = 33) Patients with AIS due to LVO (n = 33) P value AIS with good collaterals (n = 17) AIS with poor collaterals (n = 16) P value
Characteristics
 Age, median (IQR), years 52 (47.5–59) 56 (47–63) 0.602 55 (45–62) 55 (48–63) 0.711 59 (51–65) 54 (46–59) 0.188 56 (53–59) 50.5 (43.5–59.75) 0.250
 Female, n (%) 10 (50.0) 15 (37.5) 0.280 15 (45.5) 21 (31.8) 0.187 11 (33.3) 10 (30.3) 0.795 4 (23.5) 6 (37.5) 0.399
 Systolic blood pressure, mmHg 129.0 (17.4) 141.5 (17.6) 0.015 129.9 (16.3) 145.9 (22.2) 0.000 149.1 (23.8) 142.7 (20.0) 0.247 146.2 (21.2) 139.0 (18.0) 0.319
 Diastolic blood pressure, mmHg 77.5 (10.8) 82.2 (10.1) 0.115 79.6 (10.2) 85.5 (10.8) 0.012 86.8 (11.3) 84.2 (10.1) 0.339 86.6 (8.6) 81.7 (10.8) 0.172
Medical history, n (%)
 Hypertension 8 (40.0) 27 (67.5) 0.065 11 (33.3) 41 (62.1) 0.007 19 (57.6) 22 (66.7) 0.454 12 (70.6) 10 (62.5) 0.635
 Diabetes mellitus 2 (10.0) 10 (25.0) 0.203 2 (6.1) 16 (24.2) 0.027 6 (18.2) 10 (30.3) 0.257 6 (35.3) 3 (18.8) 0.301
 Coronary heart disease 3 (15.0) 4 (10.0) 0.529 5 (15.2) 5 (7.6) 0.243 2 (6.1) 3 (9.1) 0.458 3 (17.6) 0 (0.0) 0.082
 Hypercholesterolemia 3 (15.0) 5 (12.5) 0.735 3 (9.1) 6 (9.1) 1.000 3 (9.1) 3 (9.1) 1.000 2 (11.8) 1 (6.3) 0.596
 Current or previous smoking 7 (35.0) 18 (45.0) 0.561 9 (27.3) 32 (48.5) 0.044 16 (48.5) 16 (48.5) 1.000 10 (58.8) 6 (37.5) 0.233
 Heavy alcohol use 2 (10.0) 10 (25.0) 0.203 6 (18.2) 22 (33.3) 0.117 11 (33.3) 11 (33.3) 1.000 7 (41.2) 4 (25.0) 0.340
Blood test, mean (SD)
 HCY 11.0 (4.3) 16.1 (8.9) 0.023 11.3 (3.7) 14.7 (6.6) 0.008 13.8 (5.2) 15.6 (7.6) 0.264 14.3 (7.2) 17.0 (7.8) 0.326
 Cholesterol 3.9 (0.7) 3.6 (0.9) 0.364 3.9 (0.8) 3.9 (1.0) 0.980 4.1 (1.0) 3.6 (1.0) 0.075 3.7 (1.0) 3.6 (0.9) 0.795
 Triglyceride 1.6 (0.9) 1.4 (0.7) 0.360 1.5 (0.8) 1.5 (1.0) 0.977 1.3 (0.6) 1.7 (1.3) 0.128 1.5 (0.8) 2.0 (1.6) 0.284
 LDL 2.3 (0.6) 2.1 (0.8) 0.541 2.3 (0.7) 2.3 (0.9) 0.899 2.6 (0.9) 2.1 (0.7) 0.013 2.1 (0.7) 2.0 (0.7) 0.674
 CRP 7.1 (17.3) 2.1 (0.8) 0.345 5.3 (13.8) 5.1 (8.2) 0.939 5.2 (7.0) 5.0 (9.3) 0.895 2.3 (4.2) 7.8 (12.1) 0.094
  1. Data are shown as mean (SD), median (IQR) for continuous variables, and as percentages for categorical variables
  2. AIS acute ischemic stroke, IQR interquartile range, HCY homocysteine, LDL low-density lipoprotein, CRP C-reactive protein