Table 5 Allelic ratio of DNMT3A R882 mutations and clinical factors in Cox regression analysis for OS and DFS
Variables in the model | Overall survival (n = 74) | Disease-free survival (n = 51) | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
DNMT3A R882 mutation ratio, % | 1.029 (0.998–1.061) | 0.066 | 1.026 (0.990–1.063) | 0.159 |
Age, years | 1.047 (1.006–1.090) | 0.025 | 1.031 (0.984–1.081) | 0.197 |
WBC count, ×109/L | 1.005 (0.999–1.010) | 0.088 | 1.005 (0.998–1.012) | 0.171 |
Platelets count, ×109/L | 0.999 (0.995–1.003) | 0.757 | 1.001(0.996–1.005) | 0.709 |
Risk stratification | Â | 0.027 | Â | 0.032 |
 Low vs. intermediate | 1.055 (0.362–3.075) | 0. 921 | 0.618 (0.185–2.071) | 0.436 |
 High vs. intermediate | 2.758 (1.288–5.904) | 0.009 | 3.351 (1.183–9.494) | 0.023 |