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Table 5 Allelic ratio of DNMT3A R882 mutations and clinical factors in Cox regression analysis for OS and DFS

From: Influence of DNMT3A R882 mutations on AML prognosis determined by the allele ratio in Chinese patients

Variables in the model Overall survival (n = 74) Disease-free survival (n = 51)
HR (95% CI) P value HR (95% CI) P value
DNMT3A R882 mutation ratio, % 1.029 (0.998–1.061) 0.066 1.026 (0.990–1.063) 0.159
Age, years 1.047 (1.006–1.090) 0.025 1.031 (0.984–1.081) 0.197
WBC count, ×109/L 1.005 (0.999–1.010) 0.088 1.005 (0.998–1.012) 0.171
Platelets count, ×109/L 0.999 (0.995–1.003) 0.757 1.001(0.996–1.005) 0.709
Risk stratification   0.027   0.032
 Low vs. intermediate 1.055 (0.362–3.075) 0. 921 0.618 (0.185–2.071) 0.436
 High vs. intermediate 2.758 (1.288–5.904) 0.009 3.351 (1.183–9.494) 0.023
  1. HR hazard ratios, CI confidence interval, R882 arginine 882, WBC white blood cell
  2. Italic values indicate significance of P value (P < 0.05)
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Journal of Translational Medicine

ISSN: 1479-5876

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