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Table 4 DNMT3A R882 mutations and clinical factors in Cox regression analysis for AML prognosis

From: Influence of DNMT3A R882 mutations on AML prognosis determined by the allele ratio in Chinese patients

Variables in the model Overall survival (n = 870) Disease-free survival (n = 688)
HR (95% CI) P value HR (95% CI) P value
DNMT3A R882 mutations 1.725 (1.221–2.437) 0.002 1.694 (1.114–2.577) 0.014
Age, years 1.018 (1.010–1.026) 7.47 × 10 −6 1.005 (0.997–1.014) 0.229
WBC count, ×109/L 1.002 (1.001–1.004) 0.007 1.002 (1.000–1.004) 0.051
Platelets count, ×109/L 0.997 (0.995–0.999) 0.011 0.999 (0.997–1.001) 0.159
Risk stratifications   6.80 × 10 −22   9.13 × 10 −7
 Low vs. intermediate 0.681 (0.512–0.907) 0.009 0.693 (0.522–0.920) 0.011
 High vs. intermediate 2.729 (2.146–3.469) 2.53 × 10 −16 1.794 (1.323–2.433) 1.68 × 10 −4
  1. HR hazard ratios, CI confidence interval, R882 arginine 882, WBC white blood cell
  2. Italic values indicate significance of P value (P < 0.05)