Potential mediators | Direct effect | Indirect effect | P for interactiona | Proportion mediated (%)b | ||||
---|---|---|---|---|---|---|---|---|
βDir (95% CI) | Z | P | βInd (95% CI) | Z | P | |||
WC | 0.063 (0.018 to 0.108) | 2.73 | 0.006 | 0.034 (0.026 to 0.043) | 7.99 | < 0.001 | 0.624 | 32.7 |
BMI | 0.064 (0.018 to 0.109) | 2.74 | 0.018 | 0.016 (0.009 to 0.024) | 4.35 | < 0.001 | 0.769 | 15.4 |
TG | 0.069 (0.024 to 0.114) | 2.97 | 0.020 | 0.024 (0.170 to 0.032) | 6.51 | < 0.001 | 0.814 | 23.1 |
TC | 0.089 (0.044 to 0.134) | 3.89 | < 0.001 | 0.009 (0.005 to 0.014) | 4.16 | < 0.001 | 0.999 | 8.7 |
HDL-C | 0.094 (0.049 to 0.139) | 4.13 | < 0.001 | 0.009 (0.004 to 0.015) | 3.59 | < 0.001 | 0.871 | 8.7 |
FPG | 0.102 (0.057 to 0.146) | 4.48 | < 0.001 | 0.005 (0.002 to 0.010) | 2.58 | 0.010 | 0.627 | 4.8 |
HbA1c | 0.106 (0.062 to 0.151) | 4.69 | < 0.001 | − 0.002 (− 0.005 to − 0.001) | − 1.93 | 0.044 | 0.572 | − 1.9 |
CRE | 0.102 (0.054 to 0.149) | 4.19 | < 0.001 | 0.003 (− 0.024 to 0.025) | 0.273 | 0.785 | 0.978 | – |
PR | 0.101 (0.057 to 0.146) | 4.46 | < 0.001 | 0.002 (− 0.001 to 0.006) | 1.45 | 0.147 | 0.887 | – |
LDL-C | 0.104 (0.059 to 0.148) | 4.58 | < 0.001 | − 0.001 (− 0.003 to 0.001) | − 1.27 | 0.204 | 0.995 | – |
CRP | 0.104 (0.060 to 0.149) | 4.61 | < 0.001 | − 0.001 (− 0.002 to 0.001) | − 0.208 | 0.840 | 0.331 | – |
BUN | 0.109 (0.064 to 0.154) | 4.77 | < 0.001 | − 0.007 (− 0.015 to 0.003) | − 1.48 | 0.140 | 0.882 | – |