Skip to main content

Table 3 Direct and indirect effects of SUA on the risk of hypertension and the proportion mediated by metabolic factors

From: Mediation of the effect of serum uric acid on the risk of developing hypertension: a population-based cohort study

Potential mediators Direct effect Indirect effect P for interactiona Proportion mediated (%)b
βDir (95% CI) Z P βInd (95% CI) Z P
WC 0.063 (0.018 to 0.108) 2.73 0.006 0.034 (0.026 to 0.043) 7.99 < 0.001 0.624 32.7
BMI 0.064 (0.018 to 0.109) 2.74 0.018 0.016 (0.009 to 0.024) 4.35 < 0.001 0.769 15.4
TG 0.069 (0.024 to 0.114) 2.97 0.020 0.024 (0.170 to 0.032) 6.51 < 0.001 0.814 23.1
TC 0.089 (0.044 to 0.134) 3.89 < 0.001 0.009 (0.005 to 0.014) 4.16 < 0.001 0.999 8.7
HDL-C 0.094 (0.049 to 0.139) 4.13 < 0.001 0.009 (0.004 to 0.015) 3.59 < 0.001 0.871 8.7
FPG 0.102 (0.057 to 0.146) 4.48 < 0.001 0.005 (0.002 to 0.010) 2.58 0.010 0.627 4.8
HbA1c 0.106 (0.062 to 0.151) 4.69 < 0.001 − 0.002 (− 0.005 to − 0.001) − 1.93 0.044 0.572 − 1.9
CRE 0.102 (0.054 to 0.149) 4.19 < 0.001 0.003 (− 0.024 to 0.025) 0.273 0.785 0.978
PR 0.101 (0.057 to 0.146) 4.46 < 0.001 0.002 (− 0.001 to 0.006) 1.45 0.147 0.887
LDL-C 0.104 (0.059 to 0.148) 4.58 < 0.001 − 0.001 (− 0.003 to 0.001) − 1.27 0.204 0.995
CRP 0.104 (0.060 to 0.149) 4.61 < 0.001 − 0.001 (− 0.002 to 0.001) − 0.208 0.840 0.331
BUN 0.109 (0.064 to 0.154) 4.77 < 0.001 − 0.007 (− 0.015 to 0.003) − 1.48 0.140 0.882
  1. aThe test for statistical interaction between SUA level and mediators in relation to incident hypertension
  2. bThe proportion mediated was calculated as indirect effect divided by total effect. Total effect = 0.104 (0.060–0.149), P < 0.001