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Table 3 Direct and indirect effects of SUA on the risk of hypertension and the proportion mediated by metabolic factors

From: Mediation of the effect of serum uric acid on the risk of developing hypertension: a population-based cohort study

Potential mediators

Direct effect

Indirect effect

P for interactiona

Proportion mediated (%)b

βDir (95% CI)

Z

P

βInd (95% CI)

Z

P

WC

0.063 (0.018 to 0.108)

2.73

0.006

0.034 (0.026 to 0.043)

7.99

< 0.001

0.624

32.7

BMI

0.064 (0.018 to 0.109)

2.74

0.018

0.016 (0.009 to 0.024)

4.35

< 0.001

0.769

15.4

TG

0.069 (0.024 to 0.114)

2.97

0.020

0.024 (0.170 to 0.032)

6.51

< 0.001

0.814

23.1

TC

0.089 (0.044 to 0.134)

3.89

< 0.001

0.009 (0.005 to 0.014)

4.16

< 0.001

0.999

8.7

HDL-C

0.094 (0.049 to 0.139)

4.13

< 0.001

0.009 (0.004 to 0.015)

3.59

< 0.001

0.871

8.7

FPG

0.102 (0.057 to 0.146)

4.48

< 0.001

0.005 (0.002 to 0.010)

2.58

0.010

0.627

4.8

HbA1c

0.106 (0.062 to 0.151)

4.69

< 0.001

− 0.002 (− 0.005 to − 0.001)

− 1.93

0.044

0.572

− 1.9

CRE

0.102 (0.054 to 0.149)

4.19

< 0.001

0.003 (− 0.024 to 0.025)

0.273

0.785

0.978

PR

0.101 (0.057 to 0.146)

4.46

< 0.001

0.002 (− 0.001 to 0.006)

1.45

0.147

0.887

LDL-C

0.104 (0.059 to 0.148)

4.58

< 0.001

− 0.001 (− 0.003 to 0.001)

− 1.27

0.204

0.995

CRP

0.104 (0.060 to 0.149)

4.61

< 0.001

− 0.001 (− 0.002 to 0.001)

− 0.208

0.840

0.331

BUN

0.109 (0.064 to 0.154)

4.77

< 0.001

− 0.007 (− 0.015 to 0.003)

− 1.48

0.140

0.882

  1. aThe test for statistical interaction between SUA level and mediators in relation to incident hypertension
  2. bThe proportion mediated was calculated as indirect effect divided by total effect. Total effect = 0.104 (0.060–0.149), P < 0.001