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Table 3 Direct and indirect effects of SUA on the risk of hypertension and the proportion mediated by metabolic factors

From: Mediation of the effect of serum uric acid on the risk of developing hypertension: a population-based cohort study

Potential mediators

Direct effect

Indirect effect

P for interactiona

Proportion mediated (%)b

βDir (95% CI)

Z

P

βInd (95% CI)

Z

P

WC

0.063 (0.018 to 0.108)

2.73

0.006

0.034 (0.026 to 0.043)

7.99

< 0.001

0.624

32.7

BMI

0.064 (0.018 to 0.109)

2.74

0.018

0.016 (0.009 to 0.024)

4.35

< 0.001

0.769

15.4

TG

0.069 (0.024 to 0.114)

2.97

0.020

0.024 (0.170 to 0.032)

6.51

< 0.001

0.814

23.1

TC

0.089 (0.044 to 0.134)

3.89

< 0.001

0.009 (0.005 to 0.014)

4.16

< 0.001

0.999

8.7

HDL-C

0.094 (0.049 to 0.139)

4.13

< 0.001

0.009 (0.004 to 0.015)

3.59

< 0.001

0.871

8.7

FPG

0.102 (0.057 to 0.146)

4.48

< 0.001

0.005 (0.002 to 0.010)

2.58

0.010

0.627

4.8

HbA1c

0.106 (0.062 to 0.151)

4.69

< 0.001

− 0.002 (− 0.005 to − 0.001)

− 1.93

0.044

0.572

− 1.9

CRE

0.102 (0.054 to 0.149)

4.19

< 0.001

0.003 (− 0.024 to 0.025)

0.273

0.785

0.978

–

PR

0.101 (0.057 to 0.146)

4.46

< 0.001

0.002 (− 0.001 to 0.006)

1.45

0.147

0.887

–

LDL-C

0.104 (0.059 to 0.148)

4.58

< 0.001

− 0.001 (− 0.003 to 0.001)

− 1.27

0.204

0.995

–

CRP

0.104 (0.060 to 0.149)

4.61

< 0.001

− 0.001 (− 0.002 to 0.001)

− 0.208

0.840

0.331

–

BUN

0.109 (0.064 to 0.154)

4.77

< 0.001

− 0.007 (− 0.015 to 0.003)

− 1.48

0.140

0.882

–

  1. aThe test for statistical interaction between SUA level and mediators in relation to incident hypertension
  2. bThe proportion mediated was calculated as indirect effect divided by total effect. Total effect = 0.104 (0.060–0.149), P < 0.001