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Table 3 Baseline and post L4-DRG stimulation changes (given in fold) of gene expression demonstrating significant upregulation (green) for CXCL2CCL11IL36GCRPSCGB1A1IL-17FTNFRSF4PLA2G2ACREB3L3ADAMTS12IL1F10NOX1CHIABDKRB1 and downregulation (red) TLR1FFAR2IL1RAPIL1RNC5PKBIL18

From: Unilateral L4-dorsal root ganglion stimulation evokes pain relief in chronic neuropathic postsurgical knee pain and changes of inflammatory markers: part II whole transcriptome profiling

Gene

Baseline (FKPM)

SD

L4-DRG stimulation (FKPM)

SD

Fold change

p value

TLR1

8.38

0.739

7.73

0.42

− 1.57

0.011

FFAR2

8.75

0.817

8.2

0.40

− 1.46

0.038

IL1RAP

8.5

0.506

8.07

0.31

− 1.35

0.023

IL1RN

8.22

0.566

7.83

0.28

− 1.31

0.035

C5

5.94

0.252

5.6

0.29

− 1.26

0.026

PBK

4.1

0.257

3.79

0.37

− 1.23

0.037

IL18

5.69

0.266

5.39

0.39

− 1.23

0.021

SMAD1

5.91

0.237

5.63

0.38

− 1.22

0.068

NAIP

10

0.360

9.74

0.36

− 1.2

0.089

CXCL2

7.61

0.186

7.86

0.14

1.2

0.0007

CCL11

5.43

0.199

5.69

0.25

1.2

0.012

IL36G

5.84

0.263

6.12

0.22

1.21

0.0028

CRP

5.25

0.223

5.52

0.28

1.21

0.0058

SCGB1A1

4.17

0.233

4.45

0.25

1.21

0.0042

FASLG

6.52

0.276

6.8

0.32

1.21

0.08

IL17F

6.89

0.185

7.19

0.14

1.23

0.0004

TNFRSF4

6.4

0.218

6.7

0.24

1.23

0.0033

PLA2G2A

4.82

0.243

5.13

0.30

1.24

0.026

CREB3L3

4.79

0.206

5.11

0.24

1.25

0.0006

ADAMTS12

5.94

0.203

6.29

0.20

1.27

0.0003

IL1F10

6.19

0.284

6.55

0.10

1.28

0.0009

NOX1

4.83

0.245

5.19

0.29

1.28

0.0037

CHIA

4.22

0.174

4.58

0.35

1.28

0.012

BDKRB1

6.16

0.323

6.54

0.22

1.3

0.0022

CCL4L2

7.49

0.370

7.88

0.41

1.31

0.055

PTGDR

8.46

0.306

8.86

0.45

1.32

0.052

  1. p value < 0.05 was considered significant