Platelet count, aspirin use, and characteristics of host inflammatory responses in colorectal cancer

Table 2 Correlation between blood platelet count and serum cytokine levels

Variable	N (unadjusted, adjusted)	Unadjusted		Adjusted
Variable	N (unadjusted, adjusted)	Pearson r	p value	Beta	p value
IL-1RA	148, 146	0.509	< 0.001	0.428	< 0.001
IL-4	148, 146	0.384	< 0.001	0.354	< 0.001
IL-6	147, 145	0.343	< 0.001	0.265	< 0.001
IL-7	148, 146	0.531	< 0.001	0.521	< 0.001
IL-8	148, 146	0.416	< 0.001	0.286	< 0.001
IL-9	147, 145	0.243	0.003	0.237	0.002
IL-12	148, 146	0.393	< 0.001	0.363	< 0.001
IFNγ	148, 146	0.365	< 0.001	0.317	< 0.001
CXCL10	148, 146	0.156	0.058	0.107	0.158
CCL2	147, 145	0.146	0.078	0.150	0.052
CCL4	148, 146	0.159	0.054	0.094	0.213
CCL11	148, 146	0.004	0.959	0.094	0.212
PDGF	148, 146	0.474	< 0.001	0.464	< 0.001

Blood platelet count and serum cytokines were logarithmically transformed because of positive skewness. The adjusted correlations were calculated with multiple linear regression. The correlations were adjusted for tumor location (colon vs. rectum), preoperative radiotherapy or chemoradiotherapy, tumor stage variables (T1–2 vs. T3–4; N0 vs. N1–2; M0 vs. M1), patient age, patient gender, and blood hemoglobin levels
CCL: chemokine (C–C motif) ligand; CXCL: chemokine (C-X-C motif) ligand; IFN: interferon; IL: interleukin; PDGF: platelet-derived growth factor

ISSN: 1479-5876