Parameter | HR (95% CI) | P value | ci training (95% CI) | ci internal validation (95% CI) | ci in silico validation (95% CI) |
---|---|---|---|---|---|
9-gene signature | 4.44 (2.36, 8.33) | < 0.0001 | 0.70 (0.58, 0.82) | 0.74 (0.53, 0.95) | 0.65 (0.55, 0.83) |
Clinical parameters | |||||
Tumor diameter | 1.13 (1.06, 1.20) | 0.0001 | |||
Tumor differentiation | 1.58 (0.89, 2.80) | 0.115 | 0.64 (0.50, 0.78) | 0.67 (0.24, 0.99) | 0.57 (0.41, 0.73) |
9-gene signature and clinical parameters | |||||
9-gene signature | 3.95 (0.68, 7.45) | < 0.0001 | |||
Tumor diameter | 1.08 (1.01, 1.12) | 0.010 | |||
Tumor differentiation | 1.29 (0.68, 2.50) | 0.422 | 0.79 (0.55, 1.03) | 0.83 (0.57, 1.36) | 0.70 (0.58, 0.92) |
Improvement of combined model compared to | dLL | Degrees of freedom | P value | ||
---|---|---|---|---|---|
9-Gene signature only | 10.53 | 2 | < 0.001 | ||
Clinical parameters only | 83.21 | 3 | 0.01 |