Parameter | HR (95% CI) | P value | ci training (95% CI) | ci internal validation (95% CI) | ci in silico validation (95% CI) |
---|---|---|---|---|---|
9-gene signature | 5.36 (3.12, 9.21) | < 0.0001 | 0.78 (0.61, 0.95) | 0.75 (0.52, 0.96) | 0.61 (0.50, 0.84) |
Clinical parameters | |||||
Tumor diameter | 1.12 (1.06, 1.18) | 0.0001 | |||
Tumor differentiation | 1.62 (0.75, 3.51) | 0.222 | 0.69 (0.49, 0.89) | 0.73 (0.24, 1.22) | 0.56 (0.23, 0.89) |
9-gene signature and clinical parameters | |||||
9-gene signature | 5.02 (2.70, 9.36) | < 0.0001 | |||
Tumor diameter | 1.11 (1.03, 1.17) | 0.002 | |||
Tumor differentiation | 1.40 (1.03, 2.55) | 0.003 | 0.81 (0.71, 0.91) | 0.86 (0.53, 1.19) | 0.74 (0.58, 0.98) |
Improvement of combined model compared to | dLL | Degrees of freedom | P value | ||
---|---|---|---|---|---|
9-Gene signature only | 11.21 | 2 | < 0.001 | ||
Clinical parameters only | 92.11 | 2 | 0.003 |