Parameter | HR (95% CI) | P value | ci training (95% CI) | ci internal validation (95% CI) | ci in silico validation (95% CI) |
---|---|---|---|---|---|
9-gene signature | 3.37 (1.53, 7.49) | < 0.0001 | 0.79 (0.62, 0.97) | 0.77 (0.55, 0.99) | 0.65 (0.57, 0.99) |
Clinical parameters | |||||
Tumor diameter | 1.10 (0.98, 1.16) | 0.092 | |||
Tumor differentiation | 1.84 (1.55, 6.09) | 0.002 | 0.70 (0.46, 0.94) | 0.68 (0.21, 0.98) | 0.54 (0.42, 0.78) |
9-gene signature and clinical parameters | |||||
9-gene signature | 15.38 (5.02, 47.71) | < 0.0001 | |||
Tumor diameter | 1.07 (1.01, 1.20) | 0.003 | |||
Tumor differentiation | 1.39 (1.10, 3.30) | < 0.01 | 0.85 (0.74, 0.99) | 0.86 (0.58, 1.13) | 0.78 (0.61, 0.98) |
Improvement of combined model compared to | dLL | Degrees of freedom | P value | ||
---|---|---|---|---|---|
9-Gene signature only | 7.24 | 2 | < 0.001 | ||
Clinical parameters only | 23.41 | 2 | 0.082 |