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Table 5 Risk factors for lymph node metastasis and liver metastasis identified by multivariate logistic regression analysis

From: Novel nomograms to predict lymph node metastasis and liver metastasis in patients with early colon carcinoma

Clinicopathological variables Lymph node metastasis Liver metastasis
OR 95% CI P value OR 95% CI P value
Age
 <45 1    1   
 45–65 0.83 0.692–0.996 0.045 0.751 0.468–1.206 0.236
 ≥ 65 0.525 0.438–0.63 < 0.001 0.532 0.332–0.851 0.008
Marriage
 Married 1      
 Single 0.898 0.826–0.976 0.012    
 Unknown 0.806 0.675–0.962 0.017    
Race
 Asian or Pacific Islander 1      
 American Indian/Alaska Native 0.759 0.469–1.227 0.261    
 White 0.732 0.637–0.842 < 0.001    
 Black 1.022 0.863–1.21 0.799    
Histological grade
 Well differentiated 1    1   
 Moderately differentiated 1.644 1.442–1.875 < 0.001 1.501 1.032–2.184 0.034
 Poorly differentiated 3.641 3.088–4.292 < 0.001 1.670 1.028–2.714 0.038
 Undifferentiated 3.462 2.609–4.593 < 0.001 1.939 0.847–4.437 0.117
Histological type
 Adenocarcinoma 1      
 Carcinoid tumor 1.752 1.328–2.311 < 0.001    
 Neuroendocrine carcinoma 3.74 2.613–5.534 < 0.001    
 Mucinous adenocarcinoma 1.046 0.881–1.241 0.607    
 Other 1.118 0.933–1.339 0.226    
T classification
 T1 1      
 T2 2.221 2.03–2.431 < 0.001    
Tumor size
 <5 cm 1    1   
 ≥ 5 cm 1.125 1.003–1.262 0.045 2.886 2.203–3.783 < 0.001
 Unknown 0.84 0.731–0.967 0.015 2.463 1.8–3.37 < 0.001
CEA
 Negative 1    1   
 Borderline 1.468 0.743–2.9 0.269 2.763 0.367–20.815 0.324
 Positive 1.385 1.228–1.561 < 0.001 10.436 7.595–14.335 < 0.001
 Unknown 0.74 0.678–0.808 < 0.001 1.395 0.994–1.958 0.055
N classification
 N0 1    1   
 N1 NA NA NA 3.909 2.999–5.095 < 0.001
 N2 NA NA NA 12.131 8.670–16.975 < 0.001
  1. OR, odds ratio; 95% CI, 95% confidence interval; NA, not available
  2. Italic values: differences are statistically significant