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Table 2 Liver enzyme function in male and female mouse plasma after 29 days SAH5-EJ1 treatment

From: Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer

  Male Female
Control 5 mg/kg 10 mg/kg 15 mg/kg Control 5 mg/kg 10 mg/kg 15 mg/kg
BUN (mg/dL) 30 ± 9.7 26 ± 2.2 31 ± 7.3 23 ± 2.9 22 ± 5.2 19 ± 2.2 19 ± 3.0 22 ± 2.5
ALP (IU/L) 54 ± 12.9 68 ± 13.8 73 ± 19.7 58 ± 10.5 95 ± 38.8 88 ± 33.2 70 ± 48.4 62 ± 18.4
ALT (IU/L) 107 ± 29.7 124 ± 71.5 96 ± 28.3 67 ± 32.3 88 ± 22.8 79 ± 35.0 61 ± 18.5 90 ± 27.2
AST (IU/L) 87 ± 28.5 92 ± 28.6 83 ± 23.6 63 ± 13.5 107 ± 16.2 80 ± 8.3a 83 ± 19.0 93 ± 12.5
TBIL (mg/dL) 0.1 ± 0.04 0.2 ± 0.05 0.2 ± 0.04 0.2 ± 0.05 0.2 ± 0 0.2 ± 0.05 0.1 ± 0.05 0.1 ± 0b
N 5 4 5 4 5 5 5 4
  1. Blood collection for clinical chemistry analysis were collected via retro-orbital sinus puncture prior to scheduled necropsy on Day 29 and quantified using a Beckman Coulter AU480 Clinical System (Beckman Coulter; Brea, CA). Average values ± standard deviation. N represents number of mice per group. BUN blood urea nitrogen, ALP alkaline phosphatase, ALT alanine aminotransferase, AST aspartate aminotransferase, TBIL total bilirubin
  2. aAST significance determined via ANOVA-DUNNETT analysis
  3. bTBIL significance determined via Kruskal–Wallis-Dunn analysis
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