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Table 2 Liver enzyme function in male and female mouse plasma after 29 days SAH5-EJ1 treatment

From: Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer

 

Male

Female

Control

5 mg/kg

10 mg/kg

15 mg/kg

Control

5 mg/kg

10 mg/kg

15 mg/kg

BUN (mg/dL)

30 ± 9.7

26 ± 2.2

31 ± 7.3

23 ± 2.9

22 ± 5.2

19 ± 2.2

19 ± 3.0

22 ± 2.5

ALP (IU/L)

54 ± 12.9

68 ± 13.8

73 ± 19.7

58 ± 10.5

95 ± 38.8

88 ± 33.2

70 ± 48.4

62 ± 18.4

ALT (IU/L)

107 ± 29.7

124 ± 71.5

96 ± 28.3

67 ± 32.3

88 ± 22.8

79 ± 35.0

61 ± 18.5

90 ± 27.2

AST (IU/L)

87 ± 28.5

92 ± 28.6

83 ± 23.6

63 ± 13.5

107 ± 16.2

80 ± 8.3a

83 ± 19.0

93 ± 12.5

TBIL (mg/dL)

0.1 ± 0.04

0.2 ± 0.05

0.2 ± 0.04

0.2 ± 0.05

0.2 ± 0

0.2 ± 0.05

0.1 ± 0.05

0.1 ± 0b

N

5

4

5

4

5

5

5

4

  1. Blood collection for clinical chemistry analysis were collected via retro-orbital sinus puncture prior to scheduled necropsy on Day 29 and quantified using a Beckman Coulter AU480 Clinical System (Beckman Coulter; Brea, CA). Average values ± standard deviation. N represents number of mice per group. BUN blood urea nitrogen, ALP alkaline phosphatase, ALT alanine aminotransferase, AST aspartate aminotransferase, TBIL total bilirubin
  2. aAST significance determined via ANOVA-DUNNETT analysis
  3. bTBIL significance determined via Kruskal–Wallis-Dunn analysis