| |
Male
|
Female
|
|---|
|
Control
|
5 mg/kg
|
10 mg/kg
|
15 mg/kg
|
Control
|
5 mg/kg
|
10 mg/kg
|
15 mg/kg
|
|---|
|
BUN (mg/dL)
|
30 ± 9.7
|
26 ± 2.2
|
31 ± 7.3
|
23 ± 2.9
|
22 ± 5.2
|
19 ± 2.2
|
19 ± 3.0
|
22 ± 2.5
|
|
ALP (IU/L)
|
54 ± 12.9
|
68 ± 13.8
|
73 ± 19.7
|
58 ± 10.5
|
95 ± 38.8
|
88 ± 33.2
|
70 ± 48.4
|
62 ± 18.4
|
|
ALT (IU/L)
|
107 ± 29.7
|
124 ± 71.5
|
96 ± 28.3
|
67 ± 32.3
|
88 ± 22.8
|
79 ± 35.0
|
61 ± 18.5
|
90 ± 27.2
|
|
AST (IU/L)
|
87 ± 28.5
|
92 ± 28.6
|
83 ± 23.6
|
63 ± 13.5
|
107 ± 16.2
|
80 ± 8.3a
|
83 ± 19.0
|
93 ± 12.5
|
|
TBIL (mg/dL)
|
0.1 ± 0.04
|
0.2 ± 0.05
|
0.2 ± 0.04
|
0.2 ± 0.05
|
0.2 ± 0
|
0.2 ± 0.05
|
0.1 ± 0.05
|
0.1 ± 0b
|
|
N
|
5
|
4
|
5
|
4
|
5
|
5
|
5
|
4
|
- Blood collection for clinical chemistry analysis were collected via retro-orbital sinus puncture prior to scheduled necropsy on Day 29 and quantified using a Beckman Coulter AU480 Clinical System (Beckman Coulter; Brea, CA). Average values ± standard deviation. N represents number of mice per group. BUN blood urea nitrogen, ALP alkaline phosphatase, ALT alanine aminotransferase, AST aspartate aminotransferase, TBIL total bilirubin
- aAST significance determined via ANOVA-DUNNETT analysis
- bTBIL significance determined via Kruskal–Wallis-Dunn analysis
