Journal of Translational Medicine

Table 1 SAH5-EJ1 concentration in male and female mouse plasma

From: Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer

Treatment	N	SAH-EJ1 concentration (µg/mL)
Treatment	N	0.5 h	1 h	2 h	4 h	8 h	24 h
Male
Control	3	×	BQL	×	×	×	×
5 mg/kg	6	1.04	0.548	BQL	BQL	BQL	BQL
	6	1.36	0.603	BQL	BQL	BQL	BQL
	6	0.658	BQL	BQL	BQL	BQL	BQL
	Average	1.02 ± 0.35	0.576 ± 0.039	–	–	–	–
10 mg/kg	6	0.684	0.568	BQL	BQL	BQL	BQL
	6	0.514	0.589	BQL	BQL	BQL	BQL
	6	0.716	0.839	BQL	BQL	BQL	BQL
	Average	0.638 ± 0.11	0.665 ± 0.150	–	–	–	–
15 mg/kg	6	0.75	BQL	BQL	BQL	BQL	BQL
	6	1.07	0.63	0.551	BQL	BQL	BQL
	6	0.884	0.683	BQL	BQL	BQL	BQL
	Average	0.901 ± 0.16	0.657 ± 0.037	0.551	–	–	–
Female
Control	3	×	BQL	×	×	×	×
5 mg/kg	6	0.561	BQL	BQL	BQL	BQL	BQL
	6	0.555	0.508	BQL	BQL	BQL	BQL
	6	0.59	0.55	BQL	BQL	BQL	BQL
	Average	0.569 ± 0.019	0.529 ± 0.030	–	–	–	–
10 mg/kg	6	0.53	0.565	BQL	BQL	BQL	BQL
	6	0.616	BQL	BQL	BQL	BQL	BQL
	6	0.539	0.518	BQL	BQL	BQL	BQL
	Average	0.562 ± 0.047	0.542 ± 0.033	–	–	–	–
15 mg/kg	6	0.508	0.588	BQL	BQL	BQL	BQL
	6	0.599	BQL	BQL	BQL	BQL	BQL
	6	BQL	0.55	BQL	BQL	BQL	BQL
	Average	0.554 ± 0.064	0.569 ± 0.027	–	–	–	–

Blood collection time point day 1 taken at 0.5, 1, 2, 4, 8, and 24 h post tail-vein injection. Average values represent peptide concentration ± standard deviation. N represents number of mice per group. × represents time points at which blood collection was not required. BQL represents below quantifiable limits (0.5 µg/mL). Three mice were bled at each time point
Italic values indicate average of SAH5-EJ1 concentrations in plasma

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ISSN: 1479-5876

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