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Table 1 SAH5-EJ1 concentration in male and female mouse plasma

From: Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer

Treatment N SAH-EJ1 concentration (µg/mL)
0.5 h 1 h 2 h 4 h 8 h 24 h
Male
 Control 3 × BQL × × × ×
 5 mg/kg 6 1.04 0.548 BQL BQL BQL BQL
6 1.36 0.603 BQL BQL BQL BQL
6 0.658 BQL BQL BQL BQL BQL
Average 1.02 ± 0.35 0.576 ± 0.039
 10 mg/kg 6 0.684 0.568 BQL BQL BQL BQL
6 0.514 0.589 BQL BQL BQL BQL
6 0.716 0.839 BQL BQL BQL BQL
Average 0.638 ± 0.11 0.665 ± 0.150
 15 mg/kg 6 0.75 BQL BQL BQL BQL BQL
6 1.07 0.63 0.551 BQL BQL BQL
6 0.884 0.683 BQL BQL BQL BQL
Average 0.901 ± 0.16 0.657 ± 0.037 0.551
Female
 Control 3 × BQL × × × ×
 5 mg/kg 6 0.561 BQL BQL BQL BQL BQL
6 0.555 0.508 BQL BQL BQL BQL
6 0.59 0.55 BQL BQL BQL BQL
Average 0.569 ± 0.019 0.529 ± 0.030
 10 mg/kg 6 0.53 0.565 BQL BQL BQL BQL
6 0.616 BQL BQL BQL BQL BQL
6 0.539 0.518 BQL BQL BQL BQL
Average 0.562 ± 0.047 0.542 ± 0.033
 15 mg/kg 6 0.508 0.588 BQL BQL BQL BQL
6 0.599 BQL BQL BQL BQL BQL
6 BQL 0.55 BQL BQL BQL BQL
Average 0.554 ± 0.064 0.569 ± 0.027
  1. Blood collection time point day 1 taken at 0.5, 1, 2, 4, 8, and 24 h post tail-vein injection. Average values represent peptide concentration ± standard deviation. N represents number of mice per group. × represents time points at which blood collection was not required. BQL represents below quantifiable limits (0.5 µg/mL). Three mice were bled at each time point
  2. Italic values indicate average of SAH5-EJ1 concentrations in plasma
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