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Table 2 Clustering efficiency of differentiators identified based on p-value, fold change and combination of both, from data normalized by 12 methods

From: Clinical biomarker discovery by SWATH-MS based label-free quantitative proteomics: impact of criteria for identification of differentiators and data normalization method

Datasets

Clustering efficiency

p-value

Fold change

Both

A

100% (12/12 methods)

100% (12/12 methods)

100% (12/12 methods)

B

100% (12/12 methods)

42% (5/12 methods)

92% (11/12 methods)

C

75% (9/12 methods)

0% (0/12 methods)

75% (9/12 methods)

D

92% (11/12 methods)

25% (3/12 methods)

92% (11/12 methods)

E

100% (12/12 methods)

0% (0/12 methods)

100% (12/12 methods)

F

42% (5/12 methods)

66.6% (8/12 methods)

25% (3/12 methods)