Fig. 1

Scheme of experiments. It describes: a Samples used in this study which include IM-sensitive K562 cells (S) untreated or treated with imatinib (S + IM), IM-resistant K562 cells (R) and 3 datasets from public domain. b Generation of spectral ion library for all comparison groups in A from information dependent acquisition (IDA) data and generation of quantitative proteomic profile by data independent acquisition (DIA) using Sequential window acquisition of all theoretical fragment-ion spectra (SWATH). c Normalization of SWATH data using different methods. d Identification of differentiators based on p-value, fold change and combination of both followed by cluster analysis of the identified differentiators