Outcome | Risk estimate | Time-of-day | p-value |
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0–6 (n = 273) | 6–12 (n = 355) | 12–18 (n = 309) | 18–24 (n = 269) |
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All-cause mortality | Unadjusted HR (95% CI) | 1.525 (0.884–2.631)1 | Ref | 1.550 (0.910–2.642)2 | 1.153 (0.642–2.071)3 | 0.111 0.632 0.133 |
Adjusted HR (95% CI) | 1.422 (0.780–2.592)1 | Ref | 1.190 (0.644–2.198)2 | 1.155 (0.587–2.275)3 | 0.251 0.582 0.683 |
Cardiac mortality | Unadjusted HR (95% CI) | 2.073 (1.006–4.271)1 | Ref | 2.190 (1.084–4.426)2 | 1.648 (0.772–3.522)3 | 0.051 0.032 0.203 |
Adjusted HR (95% CI) | 2.083 (0.927–4.679)1 | Ref | 1.805 (0.790–4.121)2 | 1.858 (0.766–4.507)3 | 0.081 0.162 0.173 |
- The multivariable model for all-cause mortality includes hypercholesterolemia, anterolateral location of MI, time to admission, door to balloon time, presentation during office hours, age, gender, diabetes mellitus, BMI, prior MI, prior CABG, Killip class ≥ 2 at presentation, GFR, multivessel disease, no reflow after PCI, LV-EF at baseline, and infarct vessel. The multivariable model for cardiovascular mortality includes hypercholesterolemia, anterolateral location of MI, time to admission, door to balloon time, presentation during office hours, age, gender, diabetes mellitus, hypertension, prior MI, prior CABG, Killip class ≥ 2 at presentation, GFR, multivessel disease, no reflow after PCI, LV-EF at baseline, and infarct vessel
- Data are hazards ratios (HR) with 95% confidence interval (CI). The 6–12 h time interval served as reference
- 10–6 h time interval vs. reference time interval
- 212–18 h time interval vs. reference time interval
- 318–24 h time interval vs. reference time interval