Skip to main content

Table 5 Association of time-of-day at symptom onset with long-term clinical outcome (results obtained from the univariable and multivariable Cox proportional hazards model)

From: Time-of-day at symptom onset was not associated with infarct size and long-term prognosis in patients with ST-segment elevation myocardial infarction

Outcome Risk estimate Time-of-day p-value
0–6 (n = 273) 6–12 (n = 355) 12–18 (n = 309) 18–24 (n = 269)
All-cause mortality Unadjusted HR (95% CI) 1.525 (0.884–2.631)1 Ref 1.550 (0.910–2.642)2 1.153 (0.642–2.071)3 0.111
0.632
0.133
Adjusted HR (95% CI) 1.422 (0.780–2.592)1 Ref 1.190 (0.644–2.198)2 1.155 (0.587–2.275)3 0.251
0.582
0.683
Cardiac mortality Unadjusted HR (95% CI) 2.073 (1.006–4.271)1 Ref 2.190 (1.084–4.426)2 1.648 (0.772–3.522)3 0.051
0.032
0.203
Adjusted HR (95% CI) 2.083 (0.927–4.679)1 Ref 1.805 (0.790–4.121)2 1.858 (0.766–4.507)3 0.081
0.162
0.173
  1. The multivariable model for all-cause mortality includes hypercholesterolemia, anterolateral location of MI, time to admission, door to balloon time, presentation during office hours, age, gender, diabetes mellitus, BMI, prior MI, prior CABG, Killip class ≥ 2 at presentation, GFR, multivessel disease, no reflow after PCI, LV-EF at baseline, and infarct vessel. The multivariable model for cardiovascular mortality includes hypercholesterolemia, anterolateral location of MI, time to admission, door to balloon time, presentation during office hours, age, gender, diabetes mellitus, hypertension, prior MI, prior CABG, Killip class ≥ 2 at presentation, GFR, multivessel disease, no reflow after PCI, LV-EF at baseline, and infarct vessel
  2. Data are hazards ratios (HR) with 95% confidence interval (CI). The 6–12 h time interval served as reference
  3. 10–6 h time interval vs. reference time interval
  4. 212–18 h time interval vs. reference time interval
  5. 318–24 h time interval vs. reference time interval