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Table 5 Association of time-of-day at symptom onset with long-term clinical outcome (results obtained from the univariable and multivariable Cox proportional hazards model)

From: Time-of-day at symptom onset was not associated with infarct size and long-term prognosis in patients with ST-segment elevation myocardial infarction

Outcome

Risk estimate

Time-of-day

p-value

0–6 (n = 273)

6–12 (n = 355)

12–18 (n = 309)

18–24 (n = 269)

All-cause mortality

Unadjusted HR (95% CI)

1.525 (0.884–2.631)1

Ref

1.550 (0.910–2.642)2

1.153 (0.642–2.071)3

0.111

0.632

0.133

Adjusted HR (95% CI)

1.422 (0.780–2.592)1

Ref

1.190 (0.644–2.198)2

1.155 (0.587–2.275)3

0.251

0.582

0.683

Cardiac mortality

Unadjusted HR (95% CI)

2.073 (1.006–4.271)1

Ref

2.190 (1.084–4.426)2

1.648 (0.772–3.522)3

0.051

0.032

0.203

Adjusted HR (95% CI)

2.083 (0.927–4.679)1

Ref

1.805 (0.790–4.121)2

1.858 (0.766–4.507)3

0.081

0.162

0.173

  1. The multivariable model for all-cause mortality includes hypercholesterolemia, anterolateral location of MI, time to admission, door to balloon time, presentation during office hours, age, gender, diabetes mellitus, BMI, prior MI, prior CABG, Killip class ≥ 2 at presentation, GFR, multivessel disease, no reflow after PCI, LV-EF at baseline, and infarct vessel. The multivariable model for cardiovascular mortality includes hypercholesterolemia, anterolateral location of MI, time to admission, door to balloon time, presentation during office hours, age, gender, diabetes mellitus, hypertension, prior MI, prior CABG, Killip class ≥ 2 at presentation, GFR, multivessel disease, no reflow after PCI, LV-EF at baseline, and infarct vessel
  2. Data are hazards ratios (HR) with 95% confidence interval (CI). The 6–12 h time interval served as reference
  3. 10–6 h time interval vs. reference time interval
  4. 212–18 h time interval vs. reference time interval
  5. 318–24 h time interval vs. reference time interval