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Table 2 Univariable and multivariable analysis of total and subgroups of gastric cancer patients

From: Regulatory T cells and M2 macrophages present diverse prognostic value in gastric cancer patients with different clinicopathologic characteristics and chemotherapy strategies

  Univariable Multivaraible
p-value HR 95% CI p-value HR 95% CI
Total
 CD163 High vs Low 0.014 1.334 1.059 1.273 0.024* 1.335 1.04 1.715
 PD-L1 Pos vs Neg < 0.001 0.521 0.396 0.687 0.087 0.775 0.579 1.038
 CD3 High vs Low 0.031 0.776 0.616 0.978 0.456 0.906 0.698 1.175
 CD8 High vs Low 0.008 0.731 0.58 0.921 0.037* 0.75 0.573 0.982
 FOXP3lowCD163low 0.012 0.719 0.557 0.929     
Stage I–II
 FOXP3 High vs Low < 0.001 0.231 0.112 0.474 < 0.001* 0.207 0.100 0.426
Stage III–IV
 CD8 High vs Low 0.005 0.694 0.537 0.897 0.003* 0.661 0.502 0.871
 FOXP3lowCD163low < 0.001 0.547 0.408 0.734 < 0.001* 0.561 0.407 0.774
N+
 PD-L1 Pos vs Neg 0.001 0.535 0.373 0.768 0.011* 0.621 0.431 0.895
 CD3 High vs Low 0.017 0.728 0.561 0.946 0.333 0.864 0.643 1.161
 CD8 High vs Low 0.004 0.679 0.523 0.883 0.035* 0.719 0.53 0.977
 FOXP3lowCD163low 0.003 0.651 0.488 0.868 0.007* 0.654 0.479 0.892
Upper
 FOXP3highPD-L1neg < 0.001 2.623 1.666 4.13 0.002* 2.123 1.309 3.443
Middle
 PD-L1 Pos vs Neg 0.005 0.443 2.252   0.075 0.594 0.336 1.053
 CD8 High vs Low 0.029 0.606 0.387   0.015* 0.567 0.358 0.896
Lower
 PD-L1 Pos vs Neg 0.003 0.55 0.37 0.819 0.522 0.869 0.566 1.334
 CD8 High vs Low 0.034 0.692 0.492 0.973 0.042* 0.692 0.485 0.987
Tub
 CD163 High vs Low 0.040 1.647 1.022 2.653 0.026* 1.765 1.071 2.908
 PD-L1 Pos vs Neg 0.002 0.462 0.281 0.759     
 FOXP3highPD-L1neg 0.014 1.868 1.137 3.070 0.227 1.387 0.815 2.316
Por
 FOXP3 High vs Low 0.018 1.442 1.065 1.951 0.949 0.988 0.691 1.414
 CD163 High vs Low 0.015 1.462 1.075 1.989 0.277 1.215 0.855 1.724
 CD3 High vs Low 0.002 0.617 0.458 0.832 0.246 0.814 0.574 1.153
 CD8 High vs Low 0.01 0.677 0.502 0.913 0.499 0.883 0.617 1.266
Sig+Muc
 FOXP3highCD163high 0.029 0.206 0.05 0.852 0.011* 0.154 0.036 0.656
“a+b+c”
 FOXP3lowCD163low 0.001 0.319 0.161 0.634 0.001* 0.319 0.161 0.634
“a+b”
 FOXP3 High vs Low 0.006 0.502 0.308 0.818 0.022* 0.563 0.344 0.92
 CD8 High vs Low 0.003 0.506 0.323 0.793 0.006* 0.533 0.34 0.837
  1. HR hazard ratio, CI confidence interval; N+: with lymph node metastasis; Pap: papillary adenocarcinoma; Tub: tubular adenocarcinoma; Por: poor-differentiated adenocarcinoma; Sig: signet ring cell addenocaecinoma; Muc: mucinous adenocarcinoma; “a+b+c”: chemotherapy with fluorouracil cisplatin and paclitaxel; “a+b”: chemotherapy with fluorouracil and cisplatin
  2. * p-value < 0.05 in multivariable analysis