Fig. 4

Complex genomic characteristics including somatic mutation, CNV and DNA methylation. a1–a5 The rose diagrams show the number of somatic mutations for each gene in the five core clusters. b The bar plot shows the average number of mutations in the five core clusters. c An example, ERBB4, is shown. d The CNV pattern in the first core cluster. Red and blue represent amplification and deletion. e The point plot shows the number of differential methylation sites in the first core cluster. f The co-methylation pattern of each core cluster; the larger circle represents stronger correlation, red represents positive correlation, and blue represents negative correlation