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Table 3 Uni and multivariable analysis on CR status, RFS and OS in AML cohort

From: High IL2RA mRNA expression is an independent adverse prognostic biomarker in core binding factor and intermediate-risk acute myeloid leukemia

Variable Univariable Multivariable
CR RFS OS CR RFS OS
p-value p-value p-value p-value HR (95% CI) p-value HR (95% CI) p-value HR (95% CI)
Age group 0.038 0.306 0.002      0.040 1.485 (1.017–2.168)
High WBC counts 0.880 0.603 0.929       
High blast percentage 0.443 0.173 0.964       
Secondary AML 0.023 0.243 0.010       
Cytogenetics risk groups 0.006 0.001 < 0.001 0.010 2.024 (1.188–3.449) 0.045 1.400 (1.007–1.947) < 0.001 2.417 (1.480–3.948)
High IL2RA mRNA level 0.005 < 0.001 < 0.001 0.008 2.17 (1.281–5.346) < 0.001 4.008 (2.437–6.592) < 0.001 3.448 (1.839–6.462)
FLT3-ITD+ 0.183 0.019 0.018       
NPM1+ 0.963 0.955 0.507       
NPM1+FLT3-ITD 0.759 0.269 0.291       
c-KIT D816V+ 0.845 0.022 0.668    0.015 3.145 (1.251–7.0901   
CEBPADM+ 0.998 0.813 0.061