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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Reduced eIF3d accelerates HIV disease progression by attenuating CD8+ T cell function

Fig. 5

EIF3d siRNA transfection in Jurkat cells, PBMCs and CD4+ T cells resulted in an increase in NL4-3 replication. a EIF3d siRNA treatment reduced eIF3d mRNA expression in Jurkat cells by 51% after 48 h (P = 0.001). b The number of GFP-positive Jurkat cells treated with eIF3d siRNA was higher than that of control cells after 48 h (P = 0.013). c EIF3d siRNA treatment reduced eIF3d mRNA expression by 45% in PBMCs (P = 0.02). d Levels of P24 in the culture supernatant of PBMCs treated with eIF3d siRNA were higher than those in the culture supernatant of control cells after 72 h (P = 0.025). e EIF3d siRNA treatment reduced eIF3d mRNA expression by 56% in CD4+ T cells (P = 0.009). f Levels of P24 in the culture supernatant of CD4+ T cells treated with eIF3d siRNA were higher than those in the culture supernatant of control cells after 72 h (P = 0. 02)

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