Fig. 3
From: Reduced eIF3d accelerates HIV disease progression by attenuating CD8+ T cell function
Differentially expressed transcripts after eIF3d siRNA-treated compared with control siRNA-treated Jurkat cells and pathway enrichment analysis results. a PCA was used to compare the gene expression signatures of the eIF3d siRNA group and the control siRNA group. b Hierarchical cluster analysis of differentially expressed mRNAs in the eIF3d siRNA group compared with that in the control siRNA group, with P < 0.05 and an absolute fold change of at least 1.2. Each row represents an individual transcript, and each column represents an individual. c The top 10 enriched pathways of genes that were significantly altered in the eIF3d siRNA group compared with the control siRNA group with an absolute fold change of at least 1.2 and P < 0.05. Pathway enrichment analysis was performed using the IPA database, and pathways were arranged according to P values. d Transcriptome data showed that expression of SOCS-7 in Jurkat cells treated with eIF3d siRNA was 1.2-times higher than that in the control siRNA group. (P = 0.036). e In CD8+ T cells, real-time PCR detected 2.3-fold higher expression of SOCS-7 in the eIF3d siRNA group than in the control siRNA group. (P = 0.028)