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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Virus-like vaccines against HIV/SIV synergize with a subdominant antigen T cell vaccine

Fig. 2

CD8+ and CD4+ T-cell responses elicited by heterologous HIV-prime SIV-boost regimen. We vaccinated CD1 mice with a, c only the priming vectors Ad-HIVB or Ad-HIVB together Ad-Ii-SIVCErvv or b, d boosted them with MVA-SIV approx. 9–10 weeks after the prime (n = 10 for each group). 10 days after the boost we measured the numbers of IFNγ+ CD8+ (a, b) and CD4+ (c, d) T-cells per spleen by stimulating splenocytes with the noted peptide pools and analyzing them by intracellular cytokine staining followed by flow cytometry. Horizontal lines mark the geometric mean and significant differences are indicated by asterisks with *(p ≤ 0.05), **(p ≤ 0.01) and ***(p ≤ 0.001)

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