Fig. 3

Differential expression analysis of miRNAs. a Volcano plot of circulating miRNAs differentially expressed in high-risk versus low-risk patient groups. The vertical red lines indicate 1.5 fold expression change, horizontal lines indicate the p-value of 0.05 in -log2 scale. b Differential expression analysis of top 10 miRNAs tested independently in contrasts indicated for each column. c, d Expression of miRNAs in patients with high risk or low risk and in patients with T2 or T3/T4 pathological T stage of tumour (p < 0.05)