Fig. 4

Level of soluble GITR and soluble GITRL in peripheral plasma. Soluble GITR in GMG patients was significantly lower than in HDs (p = 0.0377) and OMG patients (p = 0.0002). For soluble GITRL, there was no significant difference among HDs, OMG patients, and GMG patients (p = 0.8250). There was a positive correlation between soluble GITR and frequency of Helios⁺ regulatory T cells (r = 0.4001, p = 0.0285). (*p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.001)