From: Predicting the regrowth of clinically non-functioning pituitary adenoma with a statistical model
Characteristics | All patients (n = 295) | Regrowth cohort (n = 98) | Non-regrowth cohort (n = 197) | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|---|---|---|
OR (95% CI) | p value | OR (95% CI) | p value | ||||
Gender | 0.067 | – | |||||
Female | 140 (47.46%) | 56 (57.14%) | 84 (42.64%) | 1.00 (referent) | – | ||
Male | 155 (52.54%) | 42 (42.86%) | 113 (57.36%) | 0.61 (0.36 to 1.04) | – | ||
Age | < 0.001 | < 0.001 | |||||
< 40 | 61 (20.68%) | 38 (38.78%) | 23 (11.68%) | 1.00 (referent) | 1.00 (referent) | ||
40–60 | 177 (60.00%) | 52 (53.06%) | 125 (63.45%) | 0.20 (0.10 to 0.39) | 0.22 (0.11 to 0.43) | ||
≥ 60 | 57 (19.32%) | 8 (8.16%) | 49 (24.87%) | 0.09 (0.03 to 0.24) | 0.11 (0.04 to 0.30) | ||
Tumour volume | < 0.001 | 0.01 | |||||
Macro | 181 (61.36%) | 46 (46.94%) | 135 (68.53%) | 1.00 (referent) | 1.00 (referent) | ||
Giant | 114 (38.64%) | 52 (53.06%) | 62 (31.47%) | 2.68 (1.55 to 4.62) | 2.15 (1.20 to 3.87) | ||
Knosp grade | 0.022 | 0.349 | |||||
0 | 62 (21.02%) | 11 (11.22%) | 51 (25.89%) | 1.00 (referent) | – | ||
1 | 61 (20.68%) | 21 (21.43%) | 40 (20.31%) | 1.71 (0.63 to 4.67) | – | ||
2 | 41 (13.90%) | 13 (13.27%) | 28 (14.21%) | 2.31 (0.83 to 6.41) | – | ||
3 | 27 (9.15%) | 12 (12.24%) | 15 (7.61%) | 4.29 (1.45 to 12.65) | – | ||
4 | 104 (35.25%) | 41 (41.84%) | 63 (31.98%) | 3.56 (1.49 to 8.48) | – | ||
Tumour resection rate | 0.003 | 0.254 | |||||
Total | 143 (48.47%) | 38 (38.78%) | 105 (53.30%) | 1.00 (referent) | – | ||
Subtotal | 60 (20.34%) | 16 (16.32%) | 44 (22.33%) | 1.15 (0.55 to 2.42) | – | ||
Partial | 92 (31.19%) | 44 (44.90%) | 48 (24.37%) | 2.75 (1.50 to 5.04) | – |