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Table 1 Clinical characteristics of the patients with NFPA

From: Predicting the regrowth of clinically non-functioning pituitary adenoma with a statistical model

Characteristics

All patients (n = 295)

Regrowth cohort (n = 98)

Non-regrowth cohort (n = 197)

Univariate analysis

Multivariate analysis

OR (95% CI)

p value

OR (95% CI)

p value

Gender

    

0.067

 

 Female

140 (47.46%)

56 (57.14%)

84 (42.64%)

1.00 (referent)

 

 

 Male

155 (52.54%)

42 (42.86%)

113 (57.36%)

0.61 (0.36 to 1.04)

 

 

Age

    

< 0.001

 

< 0.001

 < 40

61 (20.68%)

38 (38.78%)

23 (11.68%)

1.00 (referent)

 

1.00 (referent)

 

 40–60

177 (60.00%)

52 (53.06%)

125 (63.45%)

0.20 (0.10 to 0.39)

 

0.22 (0.11 to 0.43)

 

 ≥ 60

57 (19.32%)

8 (8.16%)

49 (24.87%)

0.09 (0.03 to 0.24)

 

0.11 (0.04 to 0.30)

 

Tumour volume

    

< 0.001

 

0.01

 Macro

181 (61.36%)

46 (46.94%)

135 (68.53%)

1.00 (referent)

 

1.00 (referent)

 

 Giant

114 (38.64%)

52 (53.06%)

62 (31.47%)

2.68 (1.55 to 4.62)

 

2.15 (1.20 to 3.87)

 

Knosp grade

    

0.022

 

0.349

 0

62 (21.02%)

11 (11.22%)

51 (25.89%)

1.00 (referent)

 

 

 1

61 (20.68%)

21 (21.43%)

40 (20.31%)

1.71 (0.63 to 4.67)

 

 

 2

41 (13.90%)

13 (13.27%)

28 (14.21%)

2.31 (0.83 to 6.41)

 

 

 3

27 (9.15%)

12 (12.24%)

15 (7.61%)

4.29 (1.45 to 12.65)

 

 

 4

104 (35.25%)

41 (41.84%)

63 (31.98%)

3.56 (1.49 to 8.48)

 

 

Tumour resection rate

    

0.003

 

0.254

 Total

143 (48.47%)

38 (38.78%)

105 (53.30%)

1.00 (referent)

 

 

 Subtotal

60 (20.34%)

16 (16.32%)

44 (22.33%)

1.15 (0.55 to 2.42)

 

 

 Partial

92 (31.19%)

44 (44.90%)

48 (24.37%)

2.75 (1.50 to 5.04)

 

 
  1. OR, odds ratios; 95% CI, 95% confidence intervals; Micro, micro-adenoma; Macro, macro-adenoma; Giant, giant adenoma; Total, total resection; Subtotal, subtotal resection; Partial, partial resection