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Table 1 Clinical characteristics of the patients with NFPA

From: Predicting the regrowth of clinically non-functioning pituitary adenoma with a statistical model

Characteristics All patients (n = 295) Regrowth cohort (n = 98) Non-regrowth cohort (n = 197) Univariate analysis Multivariate analysis
OR (95% CI) p value OR (95% CI) p value
Gender      0.067  
 Female 140 (47.46%) 56 (57.14%) 84 (42.64%) 1.00 (referent)   
 Male 155 (52.54%) 42 (42.86%) 113 (57.36%) 0.61 (0.36 to 1.04)   
Age      < 0.001   < 0.001
 < 40 61 (20.68%) 38 (38.78%) 23 (11.68%) 1.00 (referent)   1.00 (referent)  
 40–60 177 (60.00%) 52 (53.06%) 125 (63.45%) 0.20 (0.10 to 0.39)   0.22 (0.11 to 0.43)  
 ≥ 60 57 (19.32%) 8 (8.16%) 49 (24.87%) 0.09 (0.03 to 0.24)   0.11 (0.04 to 0.30)  
Tumour volume      < 0.001   0.01
 Macro 181 (61.36%) 46 (46.94%) 135 (68.53%) 1.00 (referent)   1.00 (referent)  
 Giant 114 (38.64%) 52 (53.06%) 62 (31.47%) 2.68 (1.55 to 4.62)   2.15 (1.20 to 3.87)  
Knosp grade      0.022   0.349
 0 62 (21.02%) 11 (11.22%) 51 (25.89%) 1.00 (referent)   
 1 61 (20.68%) 21 (21.43%) 40 (20.31%) 1.71 (0.63 to 4.67)   
 2 41 (13.90%) 13 (13.27%) 28 (14.21%) 2.31 (0.83 to 6.41)   
 3 27 (9.15%) 12 (12.24%) 15 (7.61%) 4.29 (1.45 to 12.65)   
 4 104 (35.25%) 41 (41.84%) 63 (31.98%) 3.56 (1.49 to 8.48)   
Tumour resection rate      0.003   0.254
 Total 143 (48.47%) 38 (38.78%) 105 (53.30%) 1.00 (referent)   
 Subtotal 60 (20.34%) 16 (16.32%) 44 (22.33%) 1.15 (0.55 to 2.42)   
 Partial 92 (31.19%) 44 (44.90%) 48 (24.37%) 2.75 (1.50 to 5.04)   
  1. OR, odds ratios; 95% CI, 95% confidence intervals; Micro, micro-adenoma; Macro, macro-adenoma; Giant, giant adenoma; Total, total resection; Subtotal, subtotal resection; Partial, partial resection