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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: ARL3 is downregulated and acts as a prognostic biomarker in glioma

Fig. 1

Expression of ARL3 was decreased in GBM. a Data from the Gravendeel database showed the differential expression of nineteen ARL family members between nontumor tissues and GBM samples. b qRT-PCR analyses of ARL3 mRNA in glioma (WHO grade II–IV) and nontumor brain tissues (nontumor, n = 3; grade II, n = 3; grade III, n = 3; grade IV, n = 3) (*P < 0.05, with one-way ANOVA). c Immunohistochemical staining of ARL3 in glioma (WHO grade II–IV) and nontumor tissues (nontumor, n = 8; grade II, n = 5; grade III, n = 17; grade IV, n = 24) (**P < 0.01, ****P < 0.0001, with one-way ANOVA). Scale bar, 50 μm. d Data from TCGA (RNA-seq; grade II, n = 226; grade III, n = 244; grade IV, n = 150) revealed that ARL3 expression decreased in GBM compared with that in grade II and III glioma (****P < 0.0001, with one-way ANOVA). e Data from the CGGA (RNA-seq; grade II, n = 109; grade III, n = 72; grade IV, n = 144) showed that ARL3 was downregulated in GBM compared with that in grade II and III glioma (****P < 0.0001, with one-way ANOVA). f Data from REMBRANDT (Microarray; grade II, n = 98; grade III, n = 85; grade IV, n = 130) revealed that ARL3 expression in GBM was lower than that in grade II and III glioma (**P < 0.01, ****P < 0.0001, with one-way ANOVA). g Data from TCGA showed that ARL3 was downregulated in the mesenchymal subtype compared with that in neural and proneural subtypes (RNA-seq; classical, n = 145; mesenchymal, n = 157; neural, n = 88; proneural, n = 138) (****P < 0.0001, with one-way ANOVA). h The level of ARL3 expression was significantly decreased in the mesenchymal subtype of glioma compared with that in the other three subtypes (CGGA, RNA-seq; classical, n = 74; mesenchymal, n = 68; neural, n = 81; proneural, n = 102) (*P < 0.05, ****P < 0.0001, with one-way ANOVA). i Data from Rembrandt showed ARL3 expression was decreased in the mesenchymal subtype compared with that in neural and proneural subtypes (RNA-seq; classical, n = 99; mesenchymal, n = 37; neural, n = 44; proneural, n = 39) (****P < 0.0001, with one-way ANOVA)

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