Skip to main content
Fig. 5 | Journal of Translational Medicine

Fig. 5

From: ALS blood expression profiling identifies new biomarkers, patient subgroups, and evidence for neutrophilia and hypoxia

Fig. 5

ALS transcriptome overlap with genes near GWAS loci. a ALS transcriptome-GWAS overlap. The 500 genes with most strongly increased (red) or decreased (blue) expression in ALS patients were evaluated for overlap (vertical axis) with genes at varying distances from 215 ALS GWAS loci (horizontal axis). b, c Average distance between ALS DEGs and the nearest GWAS locus. Figures show null distributions for the distance obtained when sampling sets of 500 genes at random (10,000 simulation trials). Vertical arrows denote average distance among the 500 genes most strongly b increased or c decreased in ALS (p-values: upper-right). d, e ALS DEGs near GWAS loci. DEGs are listed in the left margin with chromosome and nearest GWAS loci in parentheses. Figures show the distance to the nearest GWAS locus and FC estimate (red: FC > 1.20; blue: FC < 0.83). fk Expression of ALS DEGs near GWAS loci. Expression values were Z-score normalized for each cohort (boxes: middle 50% of expression value; whiskers: 10th to 90th percentiles). The sample size for each group is shown in parentheses (bottom margin)

Back to article page