Table 1 Pathway analysis main findings: gene set enrichment analysis based on 438 miRNA target genes
From: miRNA deregulation targets specific pathways in leiomyosarcoma development: an in silico analysis
Pathway | Overlap | FDR | Genes | Database |
|---|---|---|---|---|
RNA polymerase III functions | ||||
 RNA polymerase III transcription termination | 4/23 | 0.0014 | NFIC; POLR3G; POLR3H; POLR2K | REACTOME |
 RNA polymerase III chain elongation | 3/18 | 0.0067 | POLR3G; POLR3H; POLR2K | REACTOME |
 tRNA modification in the nucleus and cytosol | 4/39 | 0.0102 | URM1; ADAT1; LCMT2; OSGEP | REACTOME |
 RNA polymerase III transcription | 4/41 | 0.0121 | NFIC; POLR3G; POLR3H; POLR2K | REACTOME |
 RNA polymerase III | 3/32 | 0.0324 | POLR3G; POLR3H; POLR2K | KEGG |
Synaptic neurotransmission | ||||
 Dopaminergic synapse | 9/129 | 0.0022 | KCNJ6; ATF6B; KCNJ9; PPP2R2D; CACNA1A; GRIN2B; CREB5; GNG13; MAPK13 | KEGG |
 Synapse formation and maturation (LGI-ADAM interactions) | 3/14 | 0.0032 | CACNG8; ADAM22; CACNG2 | REACTOME |
 Depolarization of the presynaptic terminal triggers the opening of calcium channels | 2/13 | 0.0318 | CACNA1A; CACNG2 | REACTOME |
 Neurotransmitter receptor binding and downstream transmission in the postsynaptic cell | 7/142 | 0.0370 | CACNG8; KCNJ6; KCNJ9; GRIK3; CACNG2; GRIN2B; GNG13 | REACTOME |
 Morphine addiction | 5/91 | 0.0496 | KCNJ6; KCNJ9; CACNA1A; GABRG1; GNG13 | KEGG |
Other pathways | ||||
 Extrinsic pathway of fibrin clot formation | 2/5 | 0.0046 | F7; TFPI | REACTOME |
 Chemokine receptors bind chemokines | 5/56 | 0.0075 | CCL22; CCL7; ACKR2; CXCL2; CXCL16 | REACTOME |
 TP53 regulates transcription of genes involved in G1 cell cycle arrest | 2/13 | 0.0318 | CCNE1; ZNF385A | REACTOME |
 Regulation of TP53 activity through association with co-factors | 2/14 | 0.0366 | ZNF385A; TP73 | REACTOME |
 Hematopoietic cell lineage | 5/88 | 0.0440 | FCER2; CSF2; TFRC; ITGA1; CD3E | KEGG |
 Protein digestion and absorption | 5/90 | 0.0477 | COL1A1; SLC6A19; COL3A1; COL12A1; SLC8A2 | KEGG |