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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome

Fig. 4

Production of mitochondrial-derived peptides (MDP) humanin and MOTS-c after 24 h stimulation of PBMCs with LPS. LPS-induced median MDP production after 24 h incubation of PBMCs of healthy controls (n = 10), CFS patients (n = 10), QFS patients (n = 10), and asymptomatic Q fever seropositive controls (n = 10). a LPS-induced median humanin production after 24 h incubation of PBMCs, showing a significant difference in humanin production between healthy controls (395 pg/mL; 372–409) and CFS patients (364 pg/mL; IQR 316–387), QFS patients (371 pg/mL; IQR 325–384), and asymptomatic Q fever seropositive controls (354 pg/mL; 292–393) (P = 0.05). b LPS-induced median MOTS-c production after 24 h incubation of PBMCs, showing no significant difference in MOTS-c production between healthy controls and CFS patients, QFS patients, and asymptomatic Q fever seropositive controls. Data are depicted as median with IQR. QFS Q fever fatigue syndrome, CFS chronic fatigue syndrome, Q fever seropositives Q fever seropositive controls, LPS lipopolysaccharide, MDP mitochondrial-derived peptide, PBMC peripheral blood mononuclear cell, IQR interquartile range. **P ≤ 0.01, *P ≤ 0.05

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