TY - JOUR AU - Giri, Bhuwan AU - Gupta, Vineet K. AU - Yaffe, Brianna AU - Modi, Shrey AU - Roy, Pooja AU - Sethi, Vrishketan AU - Lavania, Shweta P. AU - Vickers, Selwyn M. AU - Dudeja, Vikas AU - Banerjee, Sulagna AU - Watts, Justin AU - Saluja, Ashok PY - 2019 DA - 2019/05/20 TI - Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia JO - Journal of Translational Medicine SP - 163 VL - 17 IS - 1 AB - There is an urgent need for novel and effective treatment options for acute myeloid leukemia (AML). Triptolide, a diterpenoid tri-epoxide compound isolated from the herb Tripterygium wilfordii and its water-soluble pro-drug-Minnelide have shown promising anti-cancer activity. A recent clinical trial for patients with solid tumors confirmed the safety and efficacy at biologically equivalent doses of 0.2 mg/kg/day and lower. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-019-1901-8 DO - 10.1186/s12967-019-1901-8 ID - Giri2019 ER -