Fig. 6

Cytotoxic effects and immunosuppressive activity of γδ T cells in ovarian cancer. a Representative charts of the cytotoxic ability of γδ T cells, originated from PB or OC tissues and incubated with CFSE-labeled ovarian cancer cell lines SKOV3 at an effect: target (E:T) ratio of 10:1. b γδ T cells from OC tissues killed significantly less ovarian cancer cells SKOV3 than γδ T cells from PB. The data are presented as the mean ± SEM of three independent experiments. **P < 0.01. c Suppressive effects of cocultured γδ T cells on naïve CD4⁺ T cells was analyzed in a ratio of 1:1 with stimulation by anti-CD3 and anti-CD28 antibody, irradiated PBMCs were added as APCs. γδ T cells cocultured with OC tissue supernatants could effectively inhibit the proliferative activity of naïve CD4⁺ T cells compared to control medium. C.P.M. is an abbreviation for counts per minute, the data are presented as the mean ± SEM of three independent experiments. *P < 0.05, **P < 0.01