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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Interferon gamma induces inflammatory responses through the interaction of CEACAM1 and PI3K in airway epithelial cells

Fig. 4

Effect of PI3K/Akt pathway inhibitors on IFN-γ induced CEACAM1 and its isoform expression. mRNA expression of CEACAM1-4L, -4S, -3L, and -3L in HBE cells treated with p110α/δ inhibitor (GDC0941) at 0.05 or 0.5 ng/ml (a), Akt inhibitor (GSK690693) at 0.1 or 1.0 ng/ml (b), p110α/γ/δ/β/mTOR inhibitor (BEZ235) at 0.2 or 2.0 ng/ml (c), p110α/δ/β inhibitor (LY294002) at 2.0 or 20 ng/ml (d), p110δ inhibitor (CAL101) at 0.5 or 5.0 ng/ml (E), pan-PI3K inhibitor (SHBM1009) at 0.1 or 1.0 ng/ml (F) 24 h after stimulation and treatment with vehicle (Vehicle + Vehicle), IFN-γ with vehicle, IFN-γ with various inhibitors. *, **, ***p-values less than 0.05, 0.01 and 0.005, as compared to HBE control; +, ++, +++p-values less than 0.05, 0.01 and 0.005, as compared to IFN-γ with vehicle, respectively

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