A circulating miRNA signature for early diagnosis of acute kidney injury following acute myocardial infarction

Table 2 Summarized diagnostic factors of the individual miRNAs, combined miRNA panels and serum NGAL for AKI

Variate	Value (mean ± SE)		Fold-change (AMI⁺AKI⁺/AMI⁺AKI⁻)	P (MWU test)	Cut-off	AUC (95% CI)	Sensitivity (%)	Specificity (%)
Variate	AMI⁺AKI⁻	AMI⁺AKI⁺	Fold-change (AMI⁺AKI⁺/AMI⁺AKI⁻)	P (MWU test)	Cut-off	AUC (95% CI)	Sensitivity (%)	Specificity (%)
miR-24 (Ct)	13.64 ± 0.26	11.74 ± 0.31	0.27	< 0.001	< 12.99	0.828 (0.711–0.941)	82.61	69.23
miR-23a (Ct)	12.23 ± 0.28	10.59 ± 0.32	0.32	< 0.001	< 10.89	0.801 (0.676–0.927)	60.87	92.31
miR-145 (Ct)	9.70 ± 0.31	8.16 ± 0.29	0.34	0.002	< 9.67	0.763 (0.631–0.894)	86.96	53.85
sNGAL (ng/mL)	64.32 ± 7.50	140.13 ± 24.38	2.18	0.008	> 87.45	0.735 (0.578–0.892)	63.16	84.62
miR-24 + miR-23a (score)	0.30 ± 0.04	0.66 ± 0.06	2.16	< 0.001	> 0.46	0.838 (0.728–0.948)	73.91	80.77
miR-24 + miR-145 (score)	0.29 ± 0.04	0.67 ± 0.06	2.27	< 0.001	> 0.54	0.843 (0.730–0.956)	69.57	88.46
miR-23a + miR-145 (score)	0.35 ± 0.04	0.61 ± 0.05	1.74	< 0.001	> 0.58	0.801 (0.676–0.927)	60.87	92.31
miR-24 + miR-23a + miR-145 (score)	0.29 ± 0.04	0.67 ± 0.06	2.29	< 0.001	> 0.30	0.853 (0.744–0.962)	95.65	65.38

AKI cute kidney injury, AMI acute myocardial infarction, AUC area under receiver operating characteristic curve, CI confidence interval, Ct cycle threshold, MWU Mann–Whitney U, NGAL neutrophil gelatinase-associated lipocalin, SE standard error

ISSN: 1479-5876