From: RIPK1 suppresses apoptosis mediated by TNF and caspase-3 in intervertebral discs
Gene name | Official full name | Relevance to IVD disease | References |
---|---|---|---|
BCL2 | BCL2, apoptosis regulator | NP apoptosis, IVD degeneration | [39] |
BMP1 | Bone morphogenetic protein 1 | OA, osteoblast, osteoclast activities | |
EGFR | Epidermal growth factor receptor | IVD degeneration, OA, joint disease/arthritic joints, meniscal injury, post-traumatic OA, articular cartilage, rheumatoid arthritis (RA) | |
ERBB2 | Erb-b2 receptor tyrosine kinase 2 | IVD degeneration, arthritis, RA | |
ESR1 | Estrogen receptor 1 | Osteoporosis, OA, IVD degeneration | |
FGF2 | Fibroblast growth factor 2 | IVD degeneration, disc/bone regeneration, OA | |
IGF1 | Insulin like growth factor 1 | IVD, OA, bone formation and growth, bone mineral density | |
LCK | LCK proto-oncogene, Src family tyrosine kinase | RA | [61] |
MMP1 | Matrix metallopeptidase 1 | Arthritis, IVD, OA, articular cartilage | |
MMP13 | Matrix metallopeptidase 13 | Arthritis, OA, IVD degeneration, OA, chondrocytes | |
MMP2 | Matrix metallopeptidase 2 | IVD, bone mineralization, joint erosion and defects, OA, RA | |
MMP3 | Matrix metallopeptidase 3 | Cervical spondylosis, IVD degeneration, OA | |
MMP7 | Matrix metallopeptidase 7 | Arthritis, IVD, OA | |
MMP9 | Matrix metallopeptidase 9 | Arthritis, IVD, RA, OA | |
NFKB1 | Nuclear factor NF-kappa-B p105 subunit | OA, IVD degeneration, cervical spondylosis, bone development, osteoporosis | |
NGF | Nerve growth factor | IVD, OA, bone injury | |
PDPK1 | 3-Phosphoinositide dependent protein kinase 1 | None | Â |
PPP5C | Protein phosphatase 5 catalytic subunit | None | Â |
PTGR1 | Prostaglandin reductase 1 | None | Â |
RIPK1 | Receptor interacting serine/threonine kinase 1 | IVD, arthritis, bone marrow necroptosis | |
SRC | Proto-oncogene tyrosine-protein kinase Src | Chondrocytes, bone marrow, osteoclast, OA | |
STAT3 | Signal transducer and activator of transcription 3 | Bone defect healing, OA, IVD, articular chondrocytes | |
TGFB1 | Transforming growth factor beta 1 | OA | [96] |
TGFBR1 | Transforming growth factor beta receptor 1 | OA, articular cartilage | |
UBC | Ubiquitin C | IVD, bone destruction and pathologic fracture | |
WASL | Wiskott–Aldrich syndrome like | Bone loss or osteoporosis | [101] |