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Table 2 Potential intervertebral disc degeneration-associated proteins

From: RIPK1 suppresses apoptosis mediated by TNF and caspase-3 in intervertebral discs

Gene name

Official full name

Relevance to IVD disease

References

BCL2

BCL2, apoptosis regulator

NP apoptosis, IVD degeneration

[39]

BMP1

Bone morphogenetic protein 1

OA, osteoblast, osteoclast activities

[40, 41]

EGFR

Epidermal growth factor receptor

IVD degeneration, OA, joint disease/arthritic joints, meniscal injury, post-traumatic OA, articular cartilage, rheumatoid arthritis (RA)

[42,43,44,45,46,47]

ERBB2

Erb-b2 receptor tyrosine kinase 2

IVD degeneration, arthritis, RA

[48,49,50]

ESR1

Estrogen receptor 1

Osteoporosis, OA, IVD degeneration

[51,52,53]

FGF2

Fibroblast growth factor 2

IVD degeneration, disc/bone regeneration, OA

[54,55,56]

IGF1

Insulin like growth factor 1

IVD, OA, bone formation and growth, bone mineral density

[57,58,59,60]

LCK

LCK proto-oncogene, Src family tyrosine kinase

RA

[61]

MMP1

Matrix metallopeptidase 1

Arthritis, IVD, OA, articular cartilage

[62,63,64,65]

MMP13

Matrix metallopeptidase 13

Arthritis, OA, IVD degeneration, OA, chondrocytes

[63, 64, 66,67,68]

MMP2

Matrix metallopeptidase 2

IVD, bone mineralization, joint erosion and defects, OA, RA

[40, 67, 69, 70]

MMP3

Matrix metallopeptidase 3

Cervical spondylosis, IVD degeneration, OA

[63, 71, 72]

MMP7

Matrix metallopeptidase 7

Arthritis, IVD, OA

[73,74,75]

MMP9

Matrix metallopeptidase 9

Arthritis, IVD, RA, OA

[67, 70, 76, 77]

NFKB1

Nuclear factor NF-kappa-B p105 subunit

OA, IVD degeneration, cervical spondylosis, bone development, osteoporosis

[71, 78,79,80,81]

NGF

Nerve growth factor

IVD, OA, bone injury

[82,83,84]

PDPK1

3-Phosphoinositide dependent protein kinase 1

None

 

PPP5C

Protein phosphatase 5 catalytic subunit

None

 

PTGR1

Prostaglandin reductase 1

None

 

RIPK1

Receptor interacting serine/threonine kinase 1

IVD, arthritis, bone marrow necroptosis

[85,86,87]

SRC

Proto-oncogene tyrosine-protein kinase Src

Chondrocytes, bone marrow, osteoclast, OA

[88,89,90,91]

STAT3

Signal transducer and activator of transcription 3

Bone defect healing, OA, IVD, articular chondrocytes

[92,93,94,95]

TGFB1

Transforming growth factor beta 1

OA

[96]

TGFBR1

Transforming growth factor beta receptor 1

OA, articular cartilage

[97, 98]

UBC

Ubiquitin C

IVD, bone destruction and pathologic fracture

[99, 100]

WASL

Wiskott–Aldrich syndrome like

Bone loss or osteoporosis

[101]