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Table 2 Potential intervertebral disc degeneration-associated proteins

From: RIPK1 suppresses apoptosis mediated by TNF and caspase-3 in intervertebral discs

Gene name Official full name Relevance to IVD disease References
BCL2 BCL2, apoptosis regulator NP apoptosis, IVD degeneration [39]
BMP1 Bone morphogenetic protein 1 OA, osteoblast, osteoclast activities [40, 41]
EGFR Epidermal growth factor receptor IVD degeneration, OA, joint disease/arthritic joints, meniscal injury, post-traumatic OA, articular cartilage, rheumatoid arthritis (RA) [42,43,44,45,46,47]
ERBB2 Erb-b2 receptor tyrosine kinase 2 IVD degeneration, arthritis, RA [48,49,50]
ESR1 Estrogen receptor 1 Osteoporosis, OA, IVD degeneration [51,52,53]
FGF2 Fibroblast growth factor 2 IVD degeneration, disc/bone regeneration, OA [54,55,56]
IGF1 Insulin like growth factor 1 IVD, OA, bone formation and growth, bone mineral density [57,58,59,60]
LCK LCK proto-oncogene, Src family tyrosine kinase RA [61]
MMP1 Matrix metallopeptidase 1 Arthritis, IVD, OA, articular cartilage [62,63,64,65]
MMP13 Matrix metallopeptidase 13 Arthritis, OA, IVD degeneration, OA, chondrocytes [63, 64, 66,67,68]
MMP2 Matrix metallopeptidase 2 IVD, bone mineralization, joint erosion and defects, OA, RA [40, 67, 69, 70]
MMP3 Matrix metallopeptidase 3 Cervical spondylosis, IVD degeneration, OA [63, 71, 72]
MMP7 Matrix metallopeptidase 7 Arthritis, IVD, OA [73,74,75]
MMP9 Matrix metallopeptidase 9 Arthritis, IVD, RA, OA [67, 70, 76, 77]
NFKB1 Nuclear factor NF-kappa-B p105 subunit OA, IVD degeneration, cervical spondylosis, bone development, osteoporosis [71, 78,79,80,81]
NGF Nerve growth factor IVD, OA, bone injury [82,83,84]
PDPK1 3-Phosphoinositide dependent protein kinase 1 None  
PPP5C Protein phosphatase 5 catalytic subunit None  
PTGR1 Prostaglandin reductase 1 None  
RIPK1 Receptor interacting serine/threonine kinase 1 IVD, arthritis, bone marrow necroptosis [85,86,87]
SRC Proto-oncogene tyrosine-protein kinase Src Chondrocytes, bone marrow, osteoclast, OA [88,89,90,91]
STAT3 Signal transducer and activator of transcription 3 Bone defect healing, OA, IVD, articular chondrocytes [92,93,94,95]
TGFB1 Transforming growth factor beta 1 OA [96]
TGFBR1 Transforming growth factor beta receptor 1 OA, articular cartilage [97, 98]
UBC Ubiquitin C IVD, bone destruction and pathologic fracture [99, 100]
WASL Wiskott–Aldrich syndrome like Bone loss or osteoporosis [101]