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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: RIPK1 suppresses apoptosis mediated by TNF and caspase-3 in intervertebral discs

Fig. 6

Apoptosis induced in animal models of caudal vertebra intervertebral disc degeneration through TNF-induced caspase-dependent RIPK1 pathway. a H&E staining of endplates of animal models of caudal vertebra intervertebral disc degeneration and control group at the indicated time. b mRNA levels of TNF, RIPK1, JNK, and IKKα in primary chondrocyte cells from endplates of animal models as indicated. c Apoptotic cells of primary chondrocyte cells from endplates of animal models treated as indicated and detected by flow cytometry. Data indicate the mean values calculated from triplicate samples from multiple independent experiments (n ≥ 3) (± SD). *P < 0.05; **P < 0.01

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