Fig. 8

PLK1, CCNA2, CCNB2 and AURKA were targets of hsa-let-7b-5p and hsa-let-7b-5p could inhibit migration and invasion, induce apoptosis and alter the cell cycle dynamics of U118MG cells. a Expression of hsa-let-7b-5p was measured using real-time PCR in U118MG cells after transfection for 48 h. b Relative expression level of PLK1, CCNA2, CCNB2, and AURKA after transfection of hsa-let-7b-5p in U118MG cells. c hsa-let-7b-5p treatment could significantly inhibit the migration of U118MG cells. Scale bars, 100 μm. d hsa-let-7b-5p treatment could significantly inhibit the invasion of U118MG cells. Scale bars, 50 μm. e hsa-let-7b-5p could significantly induce the apoptosis of U118MG cells. f hsa-let-7b-5p could effectively inhibit the cycle progression of U118MG cells