Table 1 Univariate and multivariate Cox proportional hazards regression analyses demonstrating the independence of Clock^Loss or Clock^Gain from other clinicopathological features

All gliomas (Clock^Lost)

Univariate

 Q2 vs. Q1

0.393 (0.285–0.543)

 Q3 vs. Q1

0.274 (0.193–0.387)

 Q4 vs. Q1

0.188 (0.127–0.278)

All gliomas (Clock^Gain)

Univariate

 Q2 vs. Q1

1.272 (0.813–1.991)

 Q3 vs. Q1

2.931 (1.951–4.402)

 Q4 vs. Q1

3.961 (2.668–5.882)

Astrocytoma (Clock^Gain)

Univariate

 Q2 vs. Q1

0.59 (0.242–1.468)

 Q3 vs. Q1

1.423 (0.65–3.109)

 Q4 vs. Q1

3.048 (1.514–6.137)

Oligodendroglioma (Clock^Gain)

Univariate

 Q2 vs. Q1

0.947 (0.362–2.474)

 Q3 vs. Q1

1.184 (0.475–2.951)

 Q4 vs. Q1

2.764 (1.194–6.400)

Pan-kidney (Clock^Lost)

Univariate

 Q2 vs. Q1

0.783 (0.547–1.121)

 Q3 vs. Q1

0.801 (0.568–1.131)

 Q4 vs. Q1

0.520 (0.352–0.768)

 TNM staging

2.095 (1.858–2.361)

Multivariate

 Q2 vs. Q1

0.783 (0.543–1.129)

 Q3 vs. Q1

0.764 (0.537–1.089)

 Q4 vs. Q1

0.569 (0.383–0.847)

 TNM staging

2.085 (1.848–2.354)

Pan-kidney (Clock^Gain)

Univariate

 Q2 vs. Q1

1.237 (0.838–1.825)

 Q3 vs. Q1

1.222 (0.828–1.803)

 Q4 vs. Q1

1.890 (1.311–2.725)

Multivariate

 Q2 vs. Q1

1.177 (0.790–1.752)

 Q3 vs. Q1

1.429 (0.961–2.124)

 Q4 vs. Q1

1.941 (1.333–2.826)

 TNM staging

2.092 (1.857–2.357)

Clear cell renal cell (Clock^Lost)

Univariate

 Q2 vs. Q1

0.608 (0.416–0.888)

 Q3 vs. Q1

0.546 (0.361–0.795)

 Q4 vs. Q1

0.292 (0.179–0.474)

 TNM staging

1.87 (1.641–2.132)

Multivariate

 Q2 vs. Q1

0.653 (0.447–0.955)

 Q3 vs. Q1

0.667 (0.448–0.993)

 Q4 vs. Q1

0.433 (0.265–0.708)

 TNM staging

1.798 (1.572–2.058)

Clear cell renal cell (Clock^Gain)

Univariate

 Q2 vs. Q1

1.243 (0.799–1.933)

 Q3 vs. Q1

1.001 (0.640–1.564)

 Q4 vs. Q1

1.775 (1.177–2.678)

Multivariate

 Q2 vs. Q1

1.222 (0.786–1.901)

 Q3 vs. Q1

1.284 (0.818–2.017)

 Q4 vs. Q1

1.856 (1.230–2.802)

 TNM staging

1.874 (1.642–2.138)

Bladder (Clock^Lost)

Univariate

 Q2 vs. Q1

1.088 (0.593–1.999)

 Q3 vs. Q1

1.478 (0.828–2.640)

 Q4 vs. Q1

2.081 (1.198–3.614)

 TNM staging

1.679 (1.323–2.131)

Multivariate

 Q2 vs. Q1

1.059 (0.577–1.946)

 Q3 vs. Q1

1.357 (0.759–2.426)

 Q4 vs. Q1

1.776 (1.018–3.099)

 TNM staging

1.609 (1.263–2.050)

Stomach (Clock^Lost)

Univariate

 Q2 vs. Q1

0.761 (0.389–1.485)

 Q3 vs. Q1

1.143 (0.615–2.127)

 Q4 vs. Q1

2.155 (1.255–3.702)

 TNM staging

1.372 (1.067–1.765)

Multivariate

 Q2 vs. Q1

0.731 (0.374–1.428)

 Q3 vs. Q1

1.133 (0.609–2.107)

 Q4 vs. Q1

2.070 (1.205–3.557)

 TNM staging

1.354 (1.054–1.739)

Lung (Clock^Gain)

Univariate

 Q2 vs. Q1

1.633 (0.987–2.699)

 Q3 vs. Q1

1.604 (0.973–2.644)

 Q4 vs. Q1

2.023 (1.224–3.343)

 TNM staging

1.597 (1.364–1.870)

Multivariate

 Q2 vs. Q1

1.604 (0.971–2.652)

 Q3 vs. Q1

1.434 (0.868–2.370)

 Q4 vs. Q1

1.832 (1.108–3.029)

 TNM staging

1.584 (1.348–1.861)

Pancreas (Clock^Gain)

Univariate

 Q2 vs. Q1

1.791 (0.849–3.779)

 Q3 vs. Q1

1.602 (0.740–3.470)

 Q4 vs. Q1

3.034 (1.492–6.168)

 TNM staging

1.339 (0.897–1.998)

Multivariate

 Q2 vs. Q1

1.712 (0.803–3.652)

 Q3 vs. Q1

1.584 (0.731–3.430)

 Q4 vs. Q1

2.890 (1.399–5.970)

 TNM staging

1.143 (0.756–1.728)