Fig. 5

Prognostic relevance of the hypoxia and clock crosstalk. Scatter plots depict a significant negative correlations and b significant positive correlations between hypoxia and Clock^Loss or Clock^Gain scores respectively. Patients are grouped into four categories based on median clock and hypoxia scores. At the x- and y-axes, density plots depict the distribution of clock and hypoxia scores. Kaplan–Meier analyses are performed on the four patient groups to determine the effects of crosstalk between hypoxia and c Clock^Loss and d Clock^Gain on overall survival in multiple cancers including glioma histological subtypes