Fig. 4

Circadian dysregulation drives malignant progression. Differential expression analyses are performed between 4th and 1st quartile patients determined using Clock^Loss or Clock^Gain. a Venn diagrams illustrate the number of differentially expressed genes (DEGs) and their overlapping patterns in five cohorts. Numbers in parentheses represent DEGs. Table inset depicts the number of genes that are found to be in common in five, > four and > three cancer types. Overlap between common Clock^Loss and Clock^Gain genes are also depicted. Enriched b GO terms, c KEGG ontologies and d transcription factor binding associated with DEGs