Fig. 3

Clock^Loss and Clock^Gain are independent of tumour stage. Kaplan–Meier plots are generated from patients stratified according to TNM stage and a Clock^Loss and b Clock^Gain. TNM staging is first used to stratify patients, followed by median stratification into high- and low-score groups using Clock^Loss or Clock^Gain. b Glioma histological subtypes, astrocytoma and oligodendroglioma, are quartile stratified using Clock^Gain. P values are obtained from log-rank tests. ROC analyses on c Clock^Loss and d Clock^Gain to determine the specificity and sensitivity of both gene sets in predicting 5-year overall survival rates. ROC curves generated from clock gene sets are compared to those generated from TNM staging. AUCs for TNM stage are in accordance with previous work utilising TCGA datasets [69,70,71]