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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: RSPO3 is a prognostic biomarker and mediator of invasiveness in prostate cancer

Fig. 1

RSPO3 levels are lower in human prostate carcinoma, and RSPO3 is associated with reduced biochemical relapse-free survival. a Expression levels of RSPO3 in two cohorts of prostate cancer patients. Taylor Prostate (top left)—comparison of normal tissue, localized prostate cancer, and metastatic prostate cancer, and GSE70768 Cambridge (top right)—comparison of normal tissue versus prostate carcinoma) are shown. Expression levels of RSPO3 in localized prostate cancer according to Gleason grade are also given for Taylor Prostate (bottom left), and for GSE70768 Cambridge (bottom right). 25–75 percentile range is shown by the box, median is indicated by the line inside the 25–75 percentile. Also shown are 10–90 percentile range (lines above and below the 25–75 percentile), and values outside of 10–90 percentile ranges (dots). Sample sizes are indicated below. ***p < 0.001; **p < 0.01. b Kaplan–Meier curve of biochemical relapse-free survival in the Taylor Prostate (top left), GSE70768 Cambridge (bottom left), and GSE70769 Stockholm (bottom right; validation cohort for GSE70768 Cambridge 35) cohorts. Cohorts are divided according to RSPO3 expression. Solid line, high RSPO3 expression (higher 50 percentile—Cambridge and Stockholm; higher 75 percentile Taylor); dotted line, low RSPO3 expression (lower 50 percentile—Cambridge and Stockholm; lower 25 percentile—Taylor). A log-rank test was performed for statistical significance, and hazard ratio was calculated between the two groups (shown)

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