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Table 1 Summary of mRNA expressed preferentially in primary TCs, SV40-transformed TCs, primary lung cells, and SV40-transformed primary lung cells

From: Influence of gene modification in biological behaviors and responses of mouse lung telocytes to inflammation

Compared pairs Up > 0 Up > 2 Down > 0 Down > 2
Purified TCsSV40 vs. non-purified primary lung TCs 158 0 124 0
Non-purified lung TCsSV40 vs. purified primary lung TCs 343 1 119 0
Non-purified lung TCsSV40 vs. non-purified primary lung TCs 274 1 151 0
Purified TCsSV40 vs. non-purified lung TCsSV40 64 0 75 0
Purified TCsSV40 vs. purified primary lung TCs 255 2 122 0
Purified primary lung TCs vs. non-purified primary lung TCs 0 0 23 0
Gene symbol or probe set ID Fold change p-value Gene feature
(A) Genes up/down-regulated in purified TCsSV40 compared with non-purified primary lung TCs
COL3A1 1.736972 5.20E−05 Up
SLIT3 1.428832 5.70E−05 Up
FST 1.757618 6.20E−05 Up
NNAT 1.428018 6.60E−05 Up
PCDH17 −  1.82768 7.10E−05 Down
KIAA1199 1.450952 7.60E−05 Up
BHLHE22 1.431489 8.10E−05 Up
KLHDC10 − 1.342675 8.60E−05 Down
CAPN6 − 1.502786 9.10E−05 Down
DBC1 1.42647 9.60E−05 Up
ANGPTL7 1.490275 0.000101 Up
FBN1 1.555173 0.000106 Up
IGFBP7 1.491186 0.000111 Up
COL5A2 1.521795 0.000116 Up
SPRR1B − 1.653323 0.000121 Down
PCDH7 1.645697 0.000126 Up
MBD6 − 1.354523 0.000131 Down
PPARGC1A − 1.46284 0.000135 Down
SFRP2 1.953208 0.00014 Up
UPRT − 1.391618 0.000145 Down
BNC1 1.309024 0.00015 Up
TNC 1.396486 0.000155 Up
EGR1 − 1.562517 0.00016 Down
COL12A1 1.253525 0.000165 Up
ZFP36L1 1.413153 0.00017 Up
NFAT5 − 1.658072 0.000175 Down
GFPT2 1.261057 0.00018 Up
FOXP2 1.209035 0.000185 Up
TCF20 − 1.334035 0.00019 Down
STAT3 1.388462 0.000195 Up
GATA6 1.445955 0.000199 Up
CYP51A1 1.224699 0.000204 Up
IGF1 1.320664 0.000209 Up
COL1A1 1.467933 0.000214 Up
PCDH19 − 1.536647 0.000219 Down
VLDLR − 1.263978 0.000224 Down
HOXA2 1.693458 0.000229 Up
OGT − 1.620988 0.000234 Down
ANKH − 1.252673 0.000239 Down
ZNF503 1.323818 0.000244 Up
PCDH10 1.55352 0.000249 Up
HIF1A 1.439987 0.000254 Up
TGFB1I1 1.228978 0.000259 Up
MED12 − 1.302994 0.000264 Down
FBLN2 1.27815 0.000268 Up
HMGCS1 1.267852 0.000273 Up
CPXM1 1.343796 0.000278 Up
ILDR2 1.398758 0.000283 Up
MID2 − 1.297559 0.000288 Down
SEMA3A − 1.339824 0.000293 Down
PTGS2 − 1.251508 0.000298 Down
BICC1 1.416447 0.000303 Up
KMT2D − 1.222378 0.000318 Down
NFIA 1.44573 0.000323 Up
SMO − 1.262105 0.000328 Down
TMEM238 1.23793 0.000332 Up
DNAJC1 1.241613 0.000337 Up
H2AFY2 1.200548 0.000342 Up
ARF6 1.267706 0.000347 Up
ACLY 1.32049 0.000352 Up
SPRR2F − 1.383183 0.000357 Down
SCD 1.264224 0.000362 Up
GPC4 − 1.211023 0.000367 Down
KLF9 1.351626 0.000372 Up
ITPR3 − 1.227564 0.000377 Down
CDH11 1.285389 0.000382 Up
NXN 1.291856 0.000392 Up
MMP2 1.261064 0.000397 Up
GPM6B 1.298864 0.000401 Up
GRIA3 1.443882 0.000406 Up
CCND2 − 1.243142 0.000411 Down
LOX 1.244763 0.000416 Up
MSI2 − 1.254073 0.000421 Down
FAM126A − 1.296542 0.000426 Down
TC11000974.hg.1 − 1.348845 0.000431 Down
DOCK9 − 1.213445 0.000446 Down
TRBV21OR9-2 − 1.381268 0.000451 Down
THBS1 1.376867 0.000456 Up
PLK1 1.251123 0.000461 Up
DDX26B − 1.339568 0.000465 Down
FRMD5 1.270501 0.00047 Up
ADAMTS15 1.347894 0.000475 Up
MBNL1 − 1.406503 0.00048 Down
AZIN1 − 1.31031 0.000485 Down
WT1 1.203106 0.00049 Up
COL1A2 1.333456 5.00E−04 Up
ISM1 1.372788 0.000505 Up
PRRX1 1.396349 0.00051 Up
IGIP − 1.26922 0.000515 Down
TSHZ1 1.31218 0.00052 Up
TNPO3 − 1.26636 0.000525 Down
FAM98A 1.240276 0.00053 Up
HSPA5 1.505916 0.000534 Up
PRG4 1.279794 0.000539 Up
UGCG 1.205908 0.000554 Up
CDKL5 − 1.282448 0.000559 Down
HOXB8 1.214483 0.000564 Up
RDH10 1.230479 0.000569 Up
ARL6IP1 1.267388 0.000574 Up
RNF150 1.296804 0.000594 Up
TBPL1 − 1.345451 0.000598 Down
KLF7 1.240203 0.000603 Up
ID4 1.227502 0.000608 Up
MBTPS2 − 1.372487 0.000618 Down
AHCYL2 − 1.2362 0.000623 Down
C9orf172 1.232029 0.000628 Up
THBS2 1.234081 0.000633 Up
IER5L 1.31756 0.000638 Up
FZD8 1.478565 0.000643 Up
REXO2 1.287723 0.000658 Up
MAN1A1 1.214421 0.000663 Up
PLXDC2 1.315137 0.000677 Up
DPYSL2 1.20111 0.000682 Up
INTS5 1.320636 0.000687 Up
ABCB7 − 1.288423 0.000692 Down
C3orf58 1.21307 0.000712 Up
FAM218A 1.35927 0.000717 Up
FMR1 1.401071 0.000722 Up
PCDHGC5 1.328006 0.000731 Up
TRPS1 − 1.275263 0.000736 Down
GPC6 1.24421 0.000741 Up
TC07000141.hg.1 − 1.446989 0.000771 Down
SEC23A 1.295262 0.000776 Up
ZDHHC15 − 1.240478 0.000786 Down
SMAD7 1.261408 0.000791 Up
GPC3 1.218435 0.000796 Up
TUBB4B 1.245339 0.00081 Up
TXNIP 1.202009 0.00082 Up
FIGN 1.385827 0.000825 Up
TC02002617.hg.1 − 1.775002 0.00084 Down
DTNA − 1.217215 0.00085 Down
MEIS1 1.369642 0.000855 Up
PLK2 − 1.202425 0.00086 Down
RBPJ − 1.218305 0.000864 Down
NPR2 − 1.309717 0.000869 Down
NID1 1.228805 0.000874 Up
AKT3 − 1.201507 0.000879 Down
SAT1 − 1.219609 0.000884 Down
SURF4 1.201325 0.000889 Up
CELF2 1.384512 0.000914 Up
ZBTB18 − 1.426169 0.000933 Down
TOX 1.381994 0.000938 Up
DACT1 1.205543 0.000943 Up
CASK − 1.472338 0.000958 Down
KITLG 1.267156 0.000963 Up
KMT2A − 1.28931 0.000968 Down
TRBV6-8 − 1.402432 0.000973 Down
PARP6 − 1.228703 0.000983 Down
CLMP 1.252655 0.001007 Up
EGR3 − 1.348087 0.001017 Down
PCDHB1 − 1.305233 0.001022 Down
TC10000913.hg.1 − 1.441636 0.001037 Down
TC01001567.hg.1 − 1.297173 0.001066 Down
SLC16A2 1.240464 0.001081 Up
COLEC12 1.203956 0.001096 Up
PAPD5 − 1.251764 0.001101 Down
GABRA3 1.355514 0.001116 Up
LPCAT3 1.334572 0.001126 Up
FAM102B − 1.249464 0.00113 Down
CALR 1.210971 0.00115 Up
CNTFR 1.207485 0.00116 Up
HUWE1 − 1.286372 0.001165 Down
LOXL1 1.3066 0.00117 Up
JHDM1D − 1.223213 0.00119 Down
HPRT1 − 1.395397 0.001209 Down
HOXC8 1.24955 0.001214 Up
DOCK11 − 1.266513 0.001234 Down
R3HDM2 − 1.226605 0.001278 Down
TRAM1L1 1.237032 0.001283 Up
POLA1 − 1.316949 0.001288 Down
VPS35 − 1.217861 0.001298 Down
CALU − 1.289373 0.001323 Down
CD248 1.327827 0.001347 Up
THOC2 − 1.388434 0.001377 Down
UCP2 1.214025 0.001387 Up
ETV6 1.275435 0.001396 Up
AP2S1 1.218648 0.001411 Up
PIAS1 − 1.266045 0.001475 Down
TFAP2A − 1.207326 0.00149 Down
IGFBP4 1.208644 0.0015 Up
DDIT3 − 1.300464 0.001515 Down
PRR9 − 1.306757 0.001529 Down
LRP1 1.262418 0.001539 Up
EPHA7 1.222492 0.001549 Up
GATM 1.233004 0.001594 Up
MSN − 1.260531 0.001598 Down
P4HA3 1.253025 0.001623 Up
TAF10 1.23132 0.001628 Up
PDE7B 1.265724 0.001643 Up
KLHL13 1.21332 0.001658 Up
ATP11C − 1.236782 0.001746 Down
HIST1H4L 1.225746 0.001761 Up
JMJD1C − 1.223153 0.001766 Down
WNK1 − 1.347429 0.001791 Down
ATP6AP2 − 1.265769 0.001815 Down
TRBV10-1 − 1.203962 0.001855 Down
SRPX 1.225977 0.001864 Up
FGF7 1.217304 0.001909 Up
TMTC2 1.228712 0.001914 Up
MYO1D 1.22793 0.001948 Up
SARS − 1.329997 0.001968 Down
STRBP − 1.209603 0.002002 Down
SOX4 1.201564 0.002017 Up
EGR2 − 1.203287 0.002022 Down
LCE1D − 1.216676 0.002047 Down
MED14 − 1.219439 0.002076 Down
OR10P1 − 1.236803 0.002086 Down
EXT1 1.244359 0.002091 Up
SOCS3 1.34295 0.002101 Up
CPSF6 − 1.214996 0.00216 Down
PKM 1.208686 0.00218 Up
FOSB − 1.203628 0.002293 Down
TRAPPC1 1.301019 0.002318 Up
SPRR2B − 1.274955 0.002323 Down
EMX2 1.278187 0.002396 Up
TOP1 1.225449 0.002401 Up
TBC1D19 − 1.224248 0.002406 Down
PTCHD1 − 1.206554 0.002431 Down
CDH2 1.221089 0.002441 Up
SPTLC2 1.254554 0.00252 Up
PCBP2 − 1.289738 0.002534 Down
IGKV1D-8 − 1.227643 0.002549 Down
TC03000927.hg.1 − 1.274058 0.002569 Down
TC13000014.hg.1 − 1.205937 0.002633 Down
BRAF − 1.234126 0.002648 Down
CNOT6L − 1.272615 0.002658 Down
PAN3 − 1.295252 0.002707 Down
SETBP1 1.224547 0.002712 Up
SPRR1A − 1.236736 0.002717 Down
TXLNG − 1.205245 0.002726 Down
TSC22D2 − 1.307114 0.002761 Down
ATF3 − 1.205287 0.002776 Down
FUBP1 − 1.224805 0.002781 Down
DNAJC30 1.22357 0.002825 Up
RCN3 1.218967 0.002879 Up
AGFG1 1.246198 0.002884 Up
HNRNPA3 1.23159 0.002919 Up
SRPK2 − 1.200287 0.002943 Down
ATRX − 1.226812 0.002978 Down
ADAMTS6 − 1.248056 0.002983 Down
RAB1A 1.34731 0.003022 Up
IGKV3− 11 − 1.238746 0.003121 Down
OR4C6 1.227941 0.003145 Up
XBP1 1.202697 0.00316 Up
MURC − 1.350099 0.003189 Down
SNX12 − 1.22367 0.003209 Down
TC11000975.hg.1 − 1.332179 0.003239 Down
HOXA5 1.302985 0.003268 Up
RBP1 1.216422 0.003396 Up
TC19000375.hg.1 − 1.216419 0.003406 Down
KDM6A − 1.327135 0.003505 Down
TC06001136.hg.1 − 1.438272 0.003628 Down
CAV1 − 1.206156 0.003643 Down
ACSL4 1.257627 0.003682 Up
LRP6 1.211757 0.00379 Up
HIST1H1B 1.245633 0.004096 Up
DEFB136 − 1.244558 0.00415 Down
FBXO33 1.239768 0.004229 Up
TANC2 − 1.233366 0.004303 Down
USP12 1.334372 0.004475 Up
OR5A2 − 1.287342 0.004539 Down
TC18000270.hg.1 1.23255 0.004657 Up
OR51L1 − 1.224446 0.004948 Down
OR51B6 − 1.256007 0.004992 Down
PTEN 1.249442 0.005116 Up
TMSB10 1.251421 0.005327 Up
VEZF1 − 1.29591 0.005436 Down
NFIB 1.220599 0.0055 Up
CCDC166 1.217336 0.005529 Up
STAG2 − 1.224684 0.005933 Down
PIAS2 − 1.200256 0.00648 Down
ZSWIM6 1.222542 0.00651 Up
ZNF281 1.209366 0.006697 Up
SYT11 1.201281 0.00682 Up
SCXA − 1.222753 0.007815 Down
ALX1 − 1.230342 0.007992 Down
EFNA5 1.202225 0.008702 Up
MGC15705 1.234392 0.009229 Up
GPR174 1.246926 0.009317 Up
TC09000877.hg.1 − 1.325127 0.010825 Down
KRTAP19-4 1.262139 0.010972 Up
OR52N2 1.201364 0.011977 Up
Gene symbol Fold change p-value Gene feature
(B) Genes up/down-regulated in non-purified lung TCsSV40 compared with purified primary lung TCs
COL1A1 2.030789 5.20E−05 Up
COL1A2 1.647326 5.70E−05 Up
SYVN1 1.520112 6.20E−05 Up
COL12A1 1.390303 6.60E−05 Up
MYH10 1.517922 7.10E−05 Up
ACTA1 1.453697 7.60E−05 Up
SLIT3 1.501818 8.10E−05 Up
COL3A1 1.756169 8.60E−05 Up
FBN1 1.641521 9.10E−05 Up
COL5A2 1.737694 9.60E−05 Up
GATA6 1.796826 0.000101 Up
IGFBP7 1.641817 0.000106 Up
SEMA3D 1.437537 0.000111 Up
ANGPTL7 1.811625 0.000116 Up
MEIS2 1.53255 0.000121 Up
THBS1 1.678925 0.000125 Up
HS6ST2 1.220779 0.00013 Up
BICC1 1.50068 0.000135 Up
MED12 − 1.428542 0.00014 Down
HSPA5 1.887927 0.000145 Up
PFN1 1.558653 0.00015 Up
PPARGC1A − 1.432059 0.000155 Down
NFIB 1.535713 0.00016 Up
RBPJ − 1.376913 0.000165 Down
ACTN1 1.37672 0.00017 Up
EXT1 1.57285 0.000175 Up
TNC 1.293769 0.00018 Up
PCDH7 1.762644 0.000185 Up
TXNIP 1.299338 0.000189 Up
LPCAT3 1.43629 0.000194 Up
COL4A5 1.312681 0.000199 Up
NUAK1 1.412387 0.000204 Up
ATP1A1 1.303558 0.000209 Up
WT1 1.363849 0.000214 Up
MASP1 − 1.206501 0.000219 Down
VCL 1.617321 0.000224 Up
IER5L 1.262549 0.000229 Up
MYO1D 1.463161 0.000234 Up
PLOD2 1.269697 0.000239 Up
FOXP2 1.290662 0.000244 Up
ATP1B1 1.344335 0.000248 Up
KRTAP29-1 − 1.332419 0.000253 Down
ITGAV 1.294132 0.000258 Up
CPXM1 1.343008 0.000263 Up
FST 1.55845 0.000268 Up
CTGF 1.578183 0.000273 Up
HMGCS1 1.228293 0.000278 Up
PLXDC2 1.295572 0.000288 Up
LOXL1 1.332093 0.000293 Up
TM9SF4 1.351928 0.000298 Up
GGCX 1.265383 0.000303 Up
INPPL1 1.32131 0.000308 Up
DUSP6 1.275474 0.000312 Up
NFIA 1.675759 0.000317 Up
GRIA3 1.592221 0.000322 Up
LTBP1 − 1.275386 0.000332 Down
BNC1 1.391268 0.000337 Up
FEZ1 − 1.275203 0.000342 Down
OGT − 1.599369 0.000347 Down
NXN 1.203178 0.000352 Up
HIST1H2BM 1.309386 0.000357 Up
APH1A 1.273537 0.000362 Up
TMEM259 1.230715 0.000371 Up
THBS2 1.232906 0.000376 Up
ANXA6 1.256028 0.000381 Up
CDH2 1.2585 0.000391 Up
SEC23A 1.343492 0.000401 Up
NNAT 1.433848 0.000406 Up
EMX2 1.295739 0.000411 Up
VCAM1 1.215258 0.000416 Up
DNAJC1 1.413451 0.000421 Up
PCDH19 − 1.490493 0.000426 Down
ILDR2 1.412592 0.000431 Up
DOCK3 − 1.218811 0.000445 Down
DEFB128 − 1.253647 0.00045 Down
ERO1L 1.201323 0.00046 Up
CRYBA1 − 1.209259 0.000465 Down
CELF2 1.399193 0.000475 Up
ZNF503 1.316826 0.00048 Up
TM9SF3 1.337447 0.000485 Up
PTPRD 1.337777 0.000494 Up
IGHV3-43 − 1.352419 0.000499 Down
KIAA1199 1.358808 0.000509 Up
NPR2 − 1.233749 0.000514 Down
SLC7A2 1.219152 0.000519 Up
TRBV21OR9-2 − 1.26885 0.000524 Down
TCF7L2 1.344321 0.000534 Up
SRPX 1.275048 0.000549 Up
TUBG1 1.240509 0.000554 Up
TNFAIP1 1.207721 0.000558 Up
KCNAB1 1.21542 0.000563 Up
ARF6 1.224098 0.000568 Up
FBXO33 1.218704 0.000573 Up
PRPF19 1.25947 0.000578 Up
RAPH1 1.350071 0.000583 Up
PDIA3 1.527168 0.000593 Up
PBX3 1.328363 0.000598 Up
SEC23B 1.264846 0.000603 Up
GABRA3 1.405001 0.000608 Up
ARHGAP1 1.548495 0.000617 Up
AP3S1 1.293716 0.000622 Up
NFIX 1.300317 0.000627 Up
SPTLC2 1.34066 0.000632 Up
HOXC6 1.280515 0.000637 Up
RAB11B 1.318414 0.000642 Up
FHL1 1.206581 0.000652 Up
LMO4 1.222458 0.000672 Up
GBF1 1.291975 0.000677 Up
MBD6 − 1.274947 0.000681 Down
STAT3 1.346345 0.000686 Up
TLN1 1.318005 0.000691 Up
KIDINS220 1.20164 0.000696 Up
ETV6 1.300092 0.000701 Up
ATP2A2 1.245839 0.000706 Up
PARVA 1.340702 0.000711 Up
OR10D3 − 1.379974 0.000716 Down
ILK 1.411794 0.000721 Up
PLCE1 1.207815 0.000731 Up
SERPINH1 1.307929 0.000741 Up
HIF1A 1.377218 0.000745 Up
PDIA4 1.235338 0.000755 Up
MAP4K4 1.281043 0.00076 Up
REXO2 1.383088 0.000765 Up
SLC6A17 − 1.217838 0.00077 Down
PCDH17 − 1.632353 0.000775 Down
EFNA5 1.543491 0.00078 Up
LCE3E − 1.318245 0.000785 Down
LOX 1.263793 0.00079 Up
FERMT2 1.235564 0.000795 Up
NEO1 1.379359 8.00E-04 Up
TENM3 1.236228 0.000819 Up
CDH11 1.294755 0.000824 Up
KLHDC3 1.275726 0.000829 Up
HMGA1 −  1.21677 0.000834 Down
SCD 1.277895 0.000839 Up
CCND2 − 1.222991 0.000844 Down
HES1 1.308538 0.000849 Up
PDE7B 1.38073 0.000854 Up
SPARC 1.349498 0.000864 Up
SMAD6 1.280817 0.000878 Up
SARS − 1.260078 0.000883 Down
OSBP 1.345413 0.000903 Up
ACTR1A 1.256685 0.000913 Up
RUNX1T1 − 1.252339 0.000918 Down
TFAP2A − 1.255715 0.000927 Down
NRG1 1.200557 0.000937 Up
HOXB5 − 1.295109 0.000942 Down
HECTD1 1.351927 0.000947 Up
LCE1C − 1.270503 0.000952 Down
SPRED1 1.241191 0.000957 Up
PLAG1 − 1.268008 0.000967 Down
EFNB2 1.525576 0.000972 Up
HIPK3 1.37177 0.000977 Up
ID1 1.349752 0.000982 Up
GRIA4 1.321472 0.000991 Up
FAM168A 1.339626 0.001001 Up
FAM98A 1.331744 0.001006 Up
DERL2 1.375325 0.001026 Up
HSPA4 1.279904 0.001031 Up
ABCA1 1.213015 0.001036 Up
GATM 1.418597 0.001041 Up
SLC7A11 1.218849 0.001046 Up
RAB6A 1.254262 0.00105 Up
IGF1 1.369249 0.00107 Up
CCDC80 1.219878 0.00108 Up
KMT2D − 1.206701 0.001085 Down
HOXC4 1.445692 0.00109 Up
PPP3CA 1.37054 0.001095 Up
HSPA1A 1.212978 0.0011 Up
BMPR2 1.217688 0.001105 Up
ACTG1 1.229217 0.00111 Up
ZDHHC5 1.288505 0.001114 Up
CNIH 1.285039 0.001124 Up
UNC5B 1.204984 0.001139 Up
CAPN6 − 1.418505 0.001149 Down
ZFP36L1 1.284405 0.001154 Up
FGF18 1.238166 0.001159 Up
RAB1A 1.541258 0.001164 Up
FMR1 1.333774 0.001208 Up
FAM188A 1.405263 0.001213 Up
FAM168B 1.275522 0.001228 Up
ITGB5 1.204294 0.001242 Up
KRTAP5-2 − 1.219252 0.001252 Down
FBLN5 1.287407 0.001262 Up
ACVR2A 1.403689 0.001277 Up
ADAMTS9 1.226553 0.001292 Up
NETO1 1.219365 0.001301 Up
ABI1 1.232061 0.001306 Up
INSL6 1.241028 0.001321 Up
TJP1 1.229587 0.001326 Up
HNRNPUL2 1.282031 0.001331 Up
COPG1 1.228987 0.001346 Up
COPB1 1.259033 0.001351 Up
DIO3 1.28299 0.001356 Up
DYNLL2 1.311492 0.00136 Up
DDX26B − 1.257624 0.001365 Down
SLIT2 1.236976 0.00138 Up
GPC3 1.242766 0.001385 Up
PYGB 1.210405 0.001395 Up
MSANTD2 − 1.247787 0.001405 Down
CYGB 1.321169 0.00141 Up
GPC6 1.254278 0.001415 Up
TC08000204.hg.1 − 1.443858 0.001424 Down
STK39 1.37139 0.001429 Up
RAB1B 1.242841 0.001439 Up
ELAVL2 − 1.223928 0.001449 Down
HSP90B1 1.375708 0.001474 Up
ACTN4 1.314084 0.001483 Up
HSPA1A 1.215746 0.001503 Up
AMMECR1L 1.245785 0.001508 Up
RND3 1.239337 0.001518 Up
SPRY2 1.233483 0.001523 Up
DPYSL2 1.236003 0.001528 Up
DDB1 1.27575 0.001552 Up
SMARCA2 1.262741 0.001567 Up
HDGFRP3 1.330639 0.001572 Up
SULF1 1.221198 0.001577 Up
STK19 − 1.210825 0.001594 Down
STK19 − 1.210825 0.001594 Down
UPF2 1.267351 0.001606 Up
TRBV4-1 − 1.237852 0.001621 Down
APP 1.206738 0.001636 Up
AFF4 1.209778 0.001641 Up
MEF2A 1.213845 0.001651 Up
EDEM3 1.261632 0.001661 Up
HSPA1A 1.214617 0.001666 Up
GABRA4 1.24602 0.001675 Up
SPTAN1 1.260395 0.001685 Up
TEAD1 1.355621 0.001695 Up
WNK1 − 1.539904 0.001705 Down
LRP6 1.290518 0.00171 Up
PRRX1 1.233827 0.001749 Up
HSPA1A 1.213076 0.001759 Up
RAB8A 1.200712 0.001769 Up
STIM1 1.32461 0.001779 Up
ERLEC1 1.216094 0.001793 Up
ADRB1 1.24843 0.001803 Up
TMSB10 1.475064 0.001808 Up
ALCAM 1.207847 0.001857 Up
CYP51A1 1.220803 0.001862 Up
EGR3 − 1.357705 0.001877 Down
CDC27 1.318143 0.001887 Up
PANK3 1.23265 0.001921 Up
HOXA2 1.488536 0.001951 Up
TRBV6-8 − 1.340511 0.001971 Down
CRIM1 1.207809 0.001975 Up
LMAN1 1.205915 0.00198 Up
DEFB113 − 1.249904 0.001985 Down
FN1 1.284284 0.00199 Up
PRKG1 1.239048 0.00202 Up
TC15001075.hg.1 − 1.244805 0.002025 Down
HIST1H2BJ 1.336659 0.002074 Up
TMEM57 1.269164 0.002094 Up
USP12 1.314548 0.002118 Up
CAMK2N2 1.20406 0.002143 Up
TMTC2 1.200876 0.002162 Up
ANAPC1 1.257636 0.002167 Up
C1QL3 1.224547 0.002236 Up
KPRP − 1.284699 0.002246 Down
PAPOLA 1.313258 0.002295 Up
ACTC1 1.2396 0.002305 Up
LCE2A − 1.308229 0.00232 Down
CHD4 1.255055 0.002349 Up
EIF5 1.234533 0.002354 Up
PCDH10 1.328826 0.002379 Up
MYL9 1.277676 0.002404 Up
MUT − 1.247925 0.002413 Down
MEIS1 1.223628 0.002423 Up
P2RX3 − 1.225147 0.002438 Down
UBE2M 1.345125 0.002458 Up
BMPR1A 1.384032 0.002482 Up
RAB39B − 1.28009 0.002507 Down
MBNL2 1.267238 0.002556 Up
PLK1 1.222337 0.002561 Up
TRGV8 − 1.279773 0.002586 Down
CNN1 1.208197 0.00261 Up
ZSWIM6 1.291355 0.00265 Up
EFNB1 1.235229 0.002679 Up
MAN1A1 1.233248 0.002694 Up
HOXC8 1.264716 0.002714 Up
SMAD7 1.275196 0.002763 Up
TRIP12 1.322101 0.002778 Up
ATP2B1 1.212402 0.002812 Up
MEX3C 1.246507 0.002822 Up
SEC24A 1.225516 0.002827 Up
PSMC4 1.238673 0.002837 Up
KRTAP22-2 − 1.253194 0.002846 Down
LOC100509638 − 1.331709 0.002861 Down
KDM2A 1.21736 0.00292 Up
EIF4G2 1.346528 0.002945 Up
NOXRED1 − 1.247281 0.002964 Down
TC02002617.hg.1 − 1.384833 0.002989 Down
STT3A 1.269875 0.003009 Up
TC11000975.hg.1 − 1.273558 0.003058 Down
APOBEC1 − 1.247386 0.003063 Down
PPP2R5E 1.279695 0.003078 Up
FZD8 1.347838 0.003147 Up
HIST1H2BH 1.399643 0.003176 Up
AP1G1 1.251832 0.003191 Up
C11orf73 1.210719 0.003215 Up
RTN3 1.21898 0.00323 Up
LCE1E − 1.222095 0.003255 Down
ADAM9 1.210498 0.00326 Up
CLINT1 1.294737 0.003294 Up
TRGV3 − 1.208645 0.003329 Down
P4HA3 1.227186 0.003388 Up
CELF1 1.215676 0.003417 Up
MAP4K5 1.258241 0.003422 Up
TARDBP − 1.229146 0.003486 Down
BMP4 1.239271 0.003511 Up
ACTA2 1.255606 0.003525 Up
SF3B3 1.20972 0.003614 Up
DCUN1D5 1.248267 0.003634 Up
OLFML2B 1.220926 0.003643 Up
TOP1 1.254134 0.003663 Up
BTG1 − 1.348061 0.003673 Down
CALR 1.300821 0.003703 Up
H3F3A 1.228003 0.003742 Up
PUM1 1.232872 0.00383 Up
PSMA3 1.227334 0.003845 Up
OR2H2 − 1.261057 0.003865 Down
FAR1 1.284889 0.003875 Up
RC3H2 1.209665 0.003894 Up
IGKV1D-37 1.290533 0.003899 Up
EIF4B − 1.253518 0.003949 Down
ROMO1 1.212986 0.004017 Up
NCKAP1 1.279797 0.004067 Up
HSPA2 1.241027 0.004086 Up
CPD 1.254726 0.004091 Up
NPR3 1.205107 0.004131 Up
RAP1B 1.300105 0.004165 Up
SEC62 1.322724 0.00419 Up
IGLJ4 1.46599 0.004263 Up
OR5A2 − 1.612969 0.004332 Down
IGLV6-57 1.202727 0.004342 Up
RAB21 1.224355 0.004367 Up
MMP14 1.259391 0.004465 Up
LELP1 − 1.280949 0.004475 Down
ZNF281 1.341512 0.004495 Up
KRTAP12-3 − 1.222558 0.004657 Down
MMD 1.36424 0.004691 Up
TIMP3 1.219996 0.004711 Up
ACTL8 − 1.248052 0.004746 Down
HIST1H2BE 1.383938 0.004829 Up
POLA1 − 1.226576 0.004839 Down
AIDA 1.221832 0.004854 Up
OR2H2 − 1.251288 0.004859 Down
PMP22 1.201201 0.004923 Up
KRTAP12-3 − 1.215537 0.004938 Down
SLC36A4 1.206965 0.004962 Up
SHOC2 1.224107 0.004972 Up
SOX4 1.200056 0.004977 Up
ISM1 1.253651 0.005031 Up
CSRP2 1.210735 0.005041 Up
OR4D11 − 1.307921 0.005046 Down
CAPRIN1 1.203686 0.005095 Up
PPP3R1 1.237317 0.005208 Up
PPIC 1.224048 0.005238 Up
PRAMEF10 − 1.247763 0.005257 Down
MBTPS2 − 1.210053 0.00542 Down
UBTD2 1.203269 0.00543 Up
SEC11A 1.208371 0.005449 Up
USP25 1.213603 0.005498 Up
PTMA 1.217797 0.005513 Up
FKBP1C 1.209098 0.005523 Up
ANKIB1 1.23614 0.005651 Up
GSPT1 1.233347 0.005715 Up
UCP2 1.209526 0.005735 Up
TGFB3 1.220573 0.005769 Up
HIST1H4G 1.221559 0.005803 Up
IGLJ5 − 1.226509 0.005818 Down
KIF5B 1.306336 0.005897 Up
TC10000913.hg.1 − 1.233065 0.006202 Down
TC03000927.hg.1 − 1.285309 0.006207 Down
PGRMC1 1.230418 0.006286 Up
HOXC5 1.236194 0.006291 Up
KRTAP13-4 1.202792 0.006315 Up
OR3A2 − 1.250913 0.006384 Down
SRSF6 1.240448 0.006389 Up
GTSF1L − 1.204976 0.006532 Down
SYNCRIP 1.229937 0.006571 Up
HIST1H2BO 1.347018 0.006699 Up
EPC2 1.212558 0.006748 Up
CTDSPL2 1.229495 0.006768 Up
OR10A3 − 1.206131 0.006817 Down
KRTAP7-1 − 1.297287 0.006896 Down
THOC2 − 1.220789 0.006979 Down
ETF1 1.225052 0.006984 Up
TC11000974.hg.1 − 1.273131 0.006994 Down
PRELID1 1.210411 0.007014 Up
IGHV3-38 − 1.267673 0.007029 Down
OR1L3 − 1.275722 0.007034 Down
SRP54 1.294575 0.007117 Up
EXOC5 1.217832 0.007122 Up
OR2H2 − 1.263243 0.007292 Down
OR2H2 − 1.263243 0.007292 Down
RNF122 1.27436 0.007373 Up
PTBP2 − 1.249936 0.007644 Down
ERP44 1.208521 0.007683 Up
CCR7 − 1.217568 0.007747 Down
QKI 1.209051 0.008013 Up
ZFP42 − 1.215171 0.008141 Down
IGLV3-22 − 1.215548 0.008195 Down
DEFB103A − 1.213104 0.008451 Down
OR3A3 − 1.258226 0.008495 Down
TOP2B 1.206659 0.008697 Up
PTEN 1.221197 0.008785 Up
IGHV3-66 − 1.226136 0.008839 Down
PPP6C 1.210188 0.008908 Up
PRAMEF8 − 1.238928 0.008923 Down
STRN3 1.291297 0.008948 Up
TC01003841.hg.1 − 1.354102 0.008997 Down
TC05001047.hg.1 − 1.208467 0.009046 Down
MAGT1 1.21942 0.00909 Up
OR2H2 − 1.252699 0.009179 Down
OR2H2 − 1.252699 0.009179 Down
OR2H2 − 1.252699 0.009179 Down
RPL4 − 1.201599 0.009336 Down
OSTC 1.203947 0.009622 Up
IKZF5 1.216696 0.009868 Up
KRTAP10-11 − 1.205771 0.009912 Down
NLK 1.209405 0.009932 Up
OR2W1 1.274304 0.009978 Up
OR2W1 1.274304 0.009978 Up
OR2W1 1.274304 0.009978 Up
OR2W1 1.274304 0.009978 Up
OR2W1 1.274304 0.009978 Up
OR2W1 1.274304 0.009978 Up
OR2W1 1.274304 0.009978 Up
OR2W1 1.274304 0.009978 Up
CD248 1.239436 0.010758 Up
HIST1H4F 1.204154 0.010876 Up
OR6C1 − 1.216993 0.010911 Down
TMEM202 − 1.213705 0.011093 Down
TP53INP1 − 1.205295 0.011329 Down
KPNA3 1.21541 0.011511 Up
C7orf66 − 1.226557 0.011919 Down
TMSB4XP4 1.260484 0.011964 Up
TRAV24 − 1.229097 0.012215 Down
WDR26 1.201142 0.012239 Up
KRTAP9-3 − 1.229216 0.012293 Down
CSNK1A1L 1.212513 0.012716 Up
TC08001202.hg.1 − 1.327872 0.013076 Down
TAS2R16 − 1.212834 0.013287 Down
IGHV1-8 1.229339 0.013312 Up
RAB2A 1.248861 0.013563 Up
GPRIN2 − 1.234909 0.014257 Down
DEFB118 − 1.270079 0.014778 Down
TC07000141.hg.1 − 1.33934 0.015 Down
TC02000056.hg.1 − 1.236353 0.015231 Down
LCE1D − 1.234952 0.015432 Down
FAM218A 1.265433 0.015487 Up
LCE2B − 1.208788 0.015511 Down
CRABP1 − 1.271706 0.015536 Down
OR1F1 − 1.231414 0.015841 Down
LOC100144595 − 1.207195 0.016023 Down
GALNT1 1.247945 0.016274 Up
LEP − 1.236716 0.016746 Down
DEFB136 − 1.203294 0.017223 Down
TC07000218.hg.1 − 1.256974 0.017302 Down
PPIAL4E 1.263803 0.02144 Up
USP17 1.21594 0.026188 Up
Gene symbol Fold change p-value Gene feature
(C) Genes up/down-regulated in non-purified lung TCsSV40 compared with non-purified primary lung TCs
HSPA5 2.28735 5.20E−05 Up
BNC1 1.464673 5.70E−05 Up
CAPN6 − 1.711607 6.20E−05 Down
HOXC6 1.334235 6.60E−05 Up
COL12A1 1.349599 7.10E−05 Up
IGFBP7 1.60287 7.60E−05 Up
GATA6 1.812957 8.10E−05 Up
SLIT3 1.453596 8.60E−05 Up
ANGPTL7 1.780209 9.10E−05 Up
COL5A2 1.723719 9.60E−05 Up
COL1A1 1.699369 0.000101 Up
PPARGC1A − 1.461747 0.000106 Down
MEIS2 1.482364 0.000111 Up
SYVN1 1.426147 0.000116 Up
MYH10 1.457796 0.000121 Up
MED12 − 1.423327 0.000126 Down
SMO − 1.306238 0.00013 Down
DNM1 − 1.263174 0.000135 Down
ERO1L 1.270922 0.00014 Up
PBX1 − 1.307252 0.000145 Down
THBS1 1.469591 0.00015 Up
FBN1 1.535712 0.000155 Up
TRBV21OR9-2 − 1.373795 0.00016 Down
PTPRD 1.295981 0.000165 Up
BICC1 1.467091 0.00017 Up
DUSP6 1.245629 0.000175 Up
TXNIP 1.314454 0.00018 Up
FOXP2 1.294122 0.000185 Up
COL1A2 1.44837 0.00019 Up
ACTA1 1.287627 0.000195 Up
SEMA3A − 1.310532 0.000199 Down
DES 1.335159 0.000204 Up
REXO2 1.380366 0.000209 Up
ACTN1 1.352297 0.000214 Up
VCL 1.66324 0.000219 Up
PCDH19 − 1.617275 0.000224 Down
SLC6A8 − 1.239617 0.000229 Down
PCDH17 − 1.932881 0.000239 Down
OGT − 1.657267 0.000244 Down
HOXB5 − 1.442975 0.000249 Down
SEMA3D 1.383364 0.000254 Up
MECOM − 1.327861 0.000259 Down
WT1 1.349575 0.000263 Up
KCNAB1 1.210026 0.000268 Up
RUNX1T1 − 1.360214 0.000273 Down
PLCE1 1.209156 0.000278 Up
COL3A1 1.499792 0.000283 Up
FAM102B − 1.353459 0.000288 Down
MBD6 − 1.351938 0.000293 Down
CRYBA1 − 1.269111 0.000298 Down
ANXA6 1.224881 0.000303 Up
PCDH7 1.650618 0.000308 Up
PLXDC2 1.3089 0.000313 Up
FST 1.553608 0.000318 Up
NUAK1 1.27549 0.000323 Up
COL4A5 1.276706 0.000327 Up
IGF1 1.254137 0.000332 Up
SEC23A 1.389357 0.000337 Up
ATP1B1 1.276224 0.000342 Up
HS6ST2 1.230549 0.000347 Up
ZNF462 1.218491 0.000352 Up
FAM218A 1.448595 0.000357 Up
SEC23B 1.258266 0.000362 Up
PLOD2 1.25462 0.000367 Up
DNAJC1 1.413719 0.000372 Up
RAPH1 1.369576 0.000377 Up
GRIA3 1.691491 0.000382 Up
PSMC4 1.341278 0.000387 Up
SEC24A 1.317102 0.000391 Up
TGFB1I1 1.214649 0.000396 Up
ELAVL2 − 1.263137 0.000401 Down
NRP2 − 1.307128 0.000406 Down
KIAA1199 1.371075 0.000411 Up
LPHN3 − 1.212789 0.000421 Down
ARRDC3 − 1.350686 0.000426 Down
KLHL13 1.212748 0.000431 Up
MYO1D 1.385837 0.000436 Up
TM9SF3 1.307262 0.000441 Up
TFAP2A − 1.274332 0.000446 Down
ARL6IP1 1.244781 0.000451 Up
CPXM1 1.300338 0.000455 Up
CCND2 − 1.241703 0.00046 Down
SPTLC2 1.354194 0.000465 Up
NNAT 1.392895 0.00047 Up
STK39 1.540497 0.000475 Up
ITGAV 1.267551 0.00048 Up
LTBP1 − 1.280112 0.000485 Down
CELF4 1.232625 0.00049 Up
OSBP 1.424925 0.000495 Up
MASP1 − 1.219414 5.00E−04 Down
FRMD5 − 1.36697 0.000505 Down
AP3S1 1.258065 0.00051 Up
BNC2 − 1.294519 0.000515 Down
TRPS1 − 1.34803 0.000519 Down
TUBG2 1.223767 0.000529 Up
CNN1 1.210395 0.000544 Up
TNC 1.281125 0.000549 Up
GBF1 1.314328 0.000554 Up
NFAT5 − 1.519776 0.000559 Down
NFIA 1.498716 0.000564 Up
ADAM22 1.202425 0.000584 Up
RBPJ − 1.246466 0.000588 Down
EGR1 − 1.356633 0.000593 Down
ILDR2 1.458561 0.000603 Up
FSCN1 1.213951 0.000608 Up
VGLL3 1.201156 0.000623 Up
HIF1A 1.377011 0.000633 Up
ATP2A2 1.25653 0.000638 Up
ARF6 1.256706 0.000648 Up
NETO1 1.206084 0.000662 Up
PLK1 1.239207 0.000667 Up
CAV1 − 1.227122 0.000682 Down
ATF6 1.278798 0.000697 Up
ATP1A1 1.260299 0.000702 Up
GPC3 1.252397 0.000707 Up
HSPA4 1.310919 0.000716 Up
MAP4K4 1.293954 0.000721 Up
HOXC4 1.528822 0.000736 Up
JAG1 1.203931 0.000746 Up
INPPL1 1.248465 0.000756 Up
FOSB − 1.204723 0.000766 Down
KMT2D − 1.228557 0.000771 Down
PRPF19 1.227842 0.000776 Up
CCDC80 1.225889 0.00079 Up
TM9SF4 1.256719 0.000805 Up
NXN 1.219999 0.00081 Up
COPB1 1.27883 0.00082 Up
SRPX 1.337622 0.000825 Up
SMAD7 1.390506 0.00083 Up
VPS25 1.267452 0.000835 Up
TC18000270.hg.1 1.241506 0.000844 Up
DDX26B − 1.386832 0.000854 Down
SCD 1.222675 0.000859 Up
KMT2A − 1.233077 0.000869 Down
JUNB − 1.289174 0.000874 Down
OR10P1 − 1.222678 0.000884 Down
LPCAT3 1.33701 0.000894 Up
ARHGAP1 1.390092 0.000909 Up
GRIA4 1.313269 0.000928 Up
GGCX 1.210524 0.000948 Up
CNIH 1.326625 0.000958 Up
SPARC 1.31356 0.000963 Up
S100A2 − 1.206393 0.000968 Down
THBS2 1.201097 0.000973 Up
MEF2A 1.231751 0.000977 Up
HOXC8 1.40158 0.000987 Up
SARS − 1.216959 0.001002 Down
HOXC4 1.205214 0.001017 Up
FEZ1 − 1.210057 0.001022 Down
HDGFRP3 1.360953 0.001027 Up
SMAD6 1.248102 0.001032 Up
EGR3 − 1.413218 0.001037 Down
LPL 1.241889 0.001046 Up
CREB3L1 1.208352 0.001051 Up
EXT1 1.352789 0.001066 Up
SERPINH1 1.267578 0.001071 Up
CDH11 1.256532 0.001076 Up
FAM126A − 1.231349 0.001086 Down
ZNF521 − 1.298692 0.00111 Down
PCDH18 − 1.284827 0.00113 Down
ACTN4 1.348564 0.00114 Up
C10orf53 − 1.240495 0.00115 Down
EMX2 1.428467 0.001155 Up
TUBG1 1.240367 0.001169 Up
PLAG1 − 1.253787 0.001194 Down
NEO1 1.311703 0.001209 Up
NR2F2 − 1.327418 0.001214 Down
RAB39B − 1.208364 0.001229 Down
LCE1C − 1.227094 0.001234 Down
NPR2 − 1.277907 0.001243 Down
APH1A 1.202275 0.001248 Up
PRR9 − 1.473668 0.001263 Down
FAM168A 1.316093 0.001273 Up
LOX 1.233141 0.001278 Up
ETV6 1.225393 0.001283 Up
MBNL1 − 1.348394 0.001312 Down
ZSWIM6 1.360747 0.001327 Up
GPM6B − 1.209186 0.001342 Down
FERMT2 1.204761 0.001347 Up
ISM1 1.222367 0.001357 Up
HECTD1 1.325901 0.001366 Up
GPC6 1.249832 0.001371 Up
SPRR1A − 1.304855 0.001376 Down
C17orf47 − 1.210708 0.001381 Down
POLA1 − 1.278784 0.001396 Down
RNF114 1.215485 0.001406 Up
PHLDB2 1.22064 0.001421 Up
BTG1 − 1.419463 0.001435 Down
OR2H2 − 1.386141 0.00146 Down
RAB6A 1.218989 0.00147 Up
STK19 − 1.226269 0.001482 Down
STK19 − 1.226269 0.001482 Down
EFNB1 1.214243 0.00149 Up
HIPK3 1.272379 0.001514 Up
OR2H2 − 1.336272 0.001524 Down
OR4X2 − 1.231192 0.001539 Down
ZNF503 1.203437 0.001554 Up
ABI1 1.207101 0.001568 Up
FAM188A 1.354332 0.001578 Up
MBNL2 1.315575 0.001593 Up
CDH2 1.263605 0.001618 Up
FAM98A 1.272083 0.001652 Up
DDB1 1.233239 0.001691 Up
TC11000975.hg.1 − 1.370641 0.001696 Down
DEFB128 − 1.229163 0.001701 Down
CYP51A1 1.215873 0.001706 Up
EFNA5 1.525255 0.001711 Up
CLINT1 1.352971 0.001721 Up
TCF4 − 1.350334 0.001736 Down
INTS5 1.272327 0.001741 Up
GATM 1.354506 0.00177 Up
GABRA3 1.32631 0.001775 Up
RAB1A 1.472237 0.001785 Up
TC02001150.hg.1 1.202559 0.001795 Up
CAMK2N2 1.205549 0.0018 Up
HNRNPUL2 1.26108 0.001815 Up
FGF18 1.254064 0.001829 Up
LCE3B − 1.20559 0.001849 Down
SRPR 1.282511 0.001859 Up
RNF138 1.200216 0.001864 Up
GABRB1 1.20311 0.001869 Up
ZDHHC2 1.231848 0.001879 Up
PTGS2 − 1.235944 0.001888 Down
ANGPT1 − 1.239367 0.001923 Down
CDC27 1.301846 0.001933 Up
ZFP36L2 − 1.309184 0.001957 Down
THOC2 − 1.298345 0.001972 Down
AMMECR1L 1.204913 0.001982 Up
TAGLN 1.21811 0.001997 Up
SPRR1B − 1.386398 0.002007 Down
ADAMTS6 − 1.251192 0.002021 Down
LCE3E − 1.238425 0.002036 Down
TEAD1 1.316471 0.00209 Up
OR4D11 − 1.397758 0.002115 Down
PSMD14 1.269457 0.002164 Up
INSL6 1.241962 0.002169 Up
FBXO33 1.240947 0.002174 Up
OR2H2 − 1.335922 0.002211 Down
OR2H2 − 1.335922 0.002211 Down
LCE1D − 1.24485 0.002233 Down
STIM1 1.291974 0.002253 Up
TRBV6-8 − 1.383088 0.002297 Down
PARVA 1.212507 0.002307 Up
TC11000974.hg.1 − 1.355331 0.002322 Down
CTGF 1.278251 0.002327 Up
PRKG1 1.245661 0.002341 Up
TLN1 1.209426 0.002356 Up
OR3A2 − 1.258635 0.002361 Down
NPR3 1.252907 0.002366 Up
CYGB 1.286596 0.002376 Up
ID1 1.302257 0.002396 Up
HSPA2 1.291744 0.002401 Up
DERL2 1.338707 0.002415 Up
OR2H2 − 1.331198 0.002469 Down
OR2H2 − 1.331198 0.002469 Down
OR2H2 − 1.331198 0.002469 Down
EIF4G2 1.351151 0.002548 Up
PAPOLA 1.311535 0.002578 Up
PPP3R1 1.259841 0.002588 Up
PDIA3 1.321177 0.002597 Up
HSP90B1 1.297674 0.002627 Up
EIF4A1 1.248301 0.002642 Up
TNPO3 − 1.20247 0.002676 Down
UCP2 1.245612 0.002686 Up
EEF1G 1.228255 0.00274 Up
TC13000014.hg.1 − 1.237888 0.002745 Down
TC02002617.hg.1 − 1.519734 0.00275 Down
PFN1 1.248818 0.00276 Up
ERLEC1 1.219854 0.00277 Up
GSPT1 1.296726 0.002878 Up
TC15001723.hg.1 − 1.244628 0.002883 Down
C8orf49 − 1.225571 0.002888 Down
STAT3 1.204904 0.002957 Up
MAN1A1 1.22109 0.002982 Up
ACTR1A 1.210577 0.003046 Up
TAF10 1.234009 0.003075 Up
ONECUT2 − 1.203425 0.0031 Down
PPP2R5E 1.303497 0.003105 Up
STT3A 1.268152 0.003115 Up
TC03001641.hg.1 − 1.243194 0.003134 Down
TGFB3 1.241756 0.003159 Up
DICER1 1.208135 0.003164 Up
LCE2A − 1.356188 0.003213 Down
HIST1H4J 1.203634 0.003257 Up
P4HA1 1.268543 0.003277 Up
TCF20 − 1.200225 0.003287 Down
HOXC5 1.25077 0.003302 Up
MTX2 1.203709 0.003316 Up
MUT − 1.206951 0.003376 Down
CPD 1.217165 0.003405 Up
PRELP − 1.216805 0.00343 Down
OR10D3 − 1.289554 0.003558 Down
EFNB2 1.322603 0.003563 Up
MBTPS2 − 1.219406 0.003577 Down
ACVR2A 1.277435 0.003632 Up
PCDH10 1.289149 0.003641 Up
OR3A3 − 1.294084 0.003676 Down
VAT1L 1.224017 0.003681 Up
ANKIB1 1.250405 0.003705 Up
ATP6AP2 − 1.203066 0.003829 Down
TMSB10 1.33115 0.003893 Up
MYL9 1.238522 0.003976 Up
P4HA3 1.223749 0.004006 Up
LOC100144595 − 1.210771 0.004045 Down
CCDC47 1.254626 0.004085 Up
PTP4A1 1.207393 0.004104 Up
SNX12 − 1.231653 0.004163 Down
TC03000927.hg.1 − 1.34441 0.004173 Down
PRAMEF10 − 1.226358 0.004218 Down
HIST1H2BF 1.201242 0.004331 Up
HIST1H4F 1.278307 0.004355 Up
LSM2 − 1.23126 0.00436 Down
PSMC6 1.28439 0.00437 Up
TMEM57 1.214675 0.00438 Up
TRGV8 − 1.24305 0.004449 Down
SEC11A 1.212858 0.004508 Up
OR51B6 − 1.25219 0.004528 Down
ZNF830 1.223738 0.004552 Up
TMEM238 1.259086 0.004582 Up
TOP1 1.207832 0.004685 Up
LELP1 − 1.254685 0.004764 Down
MMD 1.342077 0.004774 Up
LCE1A − 1.207411 0.004804 Down
IGKV1D-13 − 1.253243 0.004808 Down
FZD8 1.20833 0.004853 Up
OR5A2 − 1.583233 0.004887 Down
C1QL3 1.202082 0.005015 Up
PANK3 1.209123 0.00506 Up
KIF5B 1.306357 0.005094 Up
SRP54 1.335205 0.005153 Up
ETF1 1.247056 0.005385 Up
HIST1H4G 1.221559 0.005399 Up
TRIP12 1.250366 0.005463 Up
TRAJ59 1.280347 0.005591 Up
DEFB133 − 1.217544 0.00568 Down
HIST1H2BH 1.324812 0.005739 Up
ACTL8 − 1.34524 0.005828 Down
HIST1H2BO 1.331009 0.005867 Up
C16orf87 1.227019 0.005877 Up
HIST1H1B 1.236488 0.005971 Up
PPP3CA 1.2093 0.006 Up
DAZAP2 − 1.246936 0.006069 Down
C7orf66 − 1.257301 0.006168 Down
IRF2BPL 1.222737 0.006197 Up
USP12 1.245254 0.006202 Up
PGAP2 − 1.236121 0.006217 Down
WNK1 − 1.317909 0.006315 Down
FAR1 1.239903 0.006424 Up
HOXA2 1.321485 0.006497 Up
IGHV3-48 − 1.200801 0.006537 Down
LCE2C − 1.207171 0.006714 Down
PPIC 1.208975 0.006822 Up
COPA 1.213652 0.006847 Up
SPANXN3 1.276398 0.006916 Up
DCUN1D5 1.204299 0.006931 Up
RAP1B 1.238418 0.006946 Up
CMAS 1.312695 0.007064 Up
NLK 1.232188 0.007211 Up
HIST1H2BE 1.335735 0.007216 Up
HRNR − 1.31544 0.007221 Down
OR4A16 1.208665 0.007285 Up
C8orf48 1.252595 0.007477 Up
CSNK1A1 1.214353 0.007497 Up
UBE2M 1.219256 0.00761 Up
ZNF281 1.250794 0.007817 Up
IGHD2-21 − 1.332138 0.007837 Down
E2F3 1.206829 0.008019 Up
TC10000913.hg.1 − 1.226511 0.008108 Down
NCKAP1 1.22608 0.008285 Up
PPP6C 1.215357 0.008364 Up
SEC62 1.25965 0.008536 Up
EXOC5 1.207899 0.00862 Up
FKBP1C 1.20189 0.008787 Up
ZBTB6 1.223895 0.008964 Up
TRBV6-7 − 1.261291 0.009048 Down
DEFB136 − 1.297342 0.009122 Down
FGF10 − 1.247986 0.009186 Down
OR4C6 1.293432 0.00927 Up
GFPT1 1.20605 0.009309 Up
PSMA6 1.216218 0.009353 Up
TC01002282.hg.1 − 1.202154 0.009477 Down
KRTAP9-8 − 1.222393 0.009486 Down
LCE2B − 1.251225 0.009595 Down
TC17000686.hg.1 − 1.224599 0.009846 Down
TMSB4XP4 1.276305 0.009935 Up
LOC100509638 − 1.228863 0.010215 Down
OR51L1 − 1.209919 0.010486 Down
TC07000141.hg.1 − 1.389386 0.011299 Down
USP17 1.231161 0.011338 Up
BMPR1A 1.225957 0.011535 Up
IGHV1OR21-1 − 1.207255 0.011811 Down
LOC728819 1.209199 0.011968 Up
WDR26 1.21391 0.012145 Up
TC15001075.hg.1 − 1.206125 0.012165 Down
TRAPPC1 1.207842 0.012264 Up
STRN3 1.251923 0.012589 Up
IGKV1D-37 1.290804 0.012667 Up
TC05000944.hg.1 − 1.209012 0.012855 Down
KRTAP6-3 − 1.209466 0.013017 Down
TC01001567.hg.1 − 1.220919 0.013106 Down
TC08000204.hg.1 − 1.257586 0.013199 Down
TRAV24 − 1.224177 0.013224 Down
KPNA3 1.208042 0.013244 Up
CALHM1 − 1.281085 0.01346 Down
KRTAP5-6 − 1.213396 0.013514 Down
OR5W2 − 1.227139 0.013682 Down
HIST2H2BE 1.203613 0.013928 Up
TAOK1 1.203131 0.014223 Up
RBMXL2 1.242693 0.014371 Up
MGC15705 1.248494 0.014499 Up
NOP58 1.210344 0.014898 Up
TC01003841.hg.1 − 1.272609 0.014947 Down
CASK − 1.202663 0.015371 Down
GPX5 − 1.231507 0.015435 Down
IGLJ6 − 1.209384 0.015651 Down
OR6C1 − 1.220835 0.015715 Down
OR1L3 − 1.26804 0.015981 Down
IGKV1-9 − 1.205738 0.016425 Down
CSNK1A1L 1.236726 0.016981 Up
OR51A4 − 1.251899 0.017158 Down
TC07000847.hg.1 1.200866 0.017404 Up
TAS2R16 − 1.220859 0.017424 Down
EIF2S2 1.202591 0.018104 Up
RAB2A 1.218567 0.018571 Up
OR56A5 1.204074 0.022471 Up
Gene symbol Fold change p-value Gene feature
(D) Genes up/down-regulated in purified TCsSV40 compared with non-purified lung TCsSV40
ZBTB18 − 1.554972 0.000298 Down
MID2 − 1.541494 0.000126 Down
HSPA5 − 1.518909 0.000465 Down
TSC22D2 − 1.5017 0.00048 Down
VCL − 1.495358 0.000204 Down
MEIS2 − 1.460638 8.60E−05 Down
STK39 − 1.423681 0.000313 Down
CTGF − 1.421299 0.000268 Down
DOCK11 − 1.415118 0.000426 Down
ATF6 − 1.409588 0.000199 Down
SLC7A11 − 1.404048 0.000101 Down
BRAF − 1.396899 0.000755 Down
NLK − 1.384761 0.00076 Down
ERO1L − 1.366172 5.20E−05 Down
HIST1H2BE − 1.360048 0.003083 Down
MEF2A − 1.354049 0.000135 Down
CELF1 − 1.34869 0.000706 Down
HPRT1 − 1.348486 0.001415 Down
TBPL1 − 1.344601 0.000573 Down
FAM188A − 1.344027 0.000652 Down
AZIN1 − 1.322403 0.000288 Down
SYVN1 − 1.309011 0.000145 Down
HIST1H2BO − 1.308399 0.002104 Down
STRBP − 1.307068 0.000362 Down
ABCB7 − 1.302327 0.00239 Down
EFNB2 − 1.298157 0.002606 Down
ANKRD1 − 1.293984 0.000455 Down
SLC6A9 − 1.292011 0.000244 Down
RND1 − 1.288509 0.000258 Down
HOXC4 − 1.286961 0.001459 Down
PGRMC1 − 1.285024 0.000775 Down
IGHV1-8 − 1.283244 0.003162 Down
GSPT1 − 1.277447 0.002286 Down
FN1 − 1.272748 0.001287 Down
AKT3 − 1.269844 0.000436 Down
STIM1 − 1.269255 0.00139 Down
EFNA5 − 1.268694 0.002818 Down
CCDC47 − 1.265588 0.001528 Down
DES − 1.265153 0.00013 Down
PDZD8 − 1.258982 0.000696 Down
GATA6 − 1.253813 0.000637 Down
SEL1L − 1.25119 0.000603 Down
HDGFRP3 − 1.249545 0.000947 Down
ZNF827 − 1.249169 0.000175 Down
NEO1 − 1.24814 0.001996 Down
MYH10 − 1.247444 0.00049 Down
C16orf87 − 1.247099 0.002311 Down
HES1 − 1.244124 0.000308 Down
HERPUD1 − 1.239348 0.000229 Down
DUSP6 − 1.237186 0.002138 Down
RAPH1 − 1.235005 0.000992 Down
CDC42BPA − 1.233364 0.00203 Down
ACTN4 − 1.232684 0.00174 Down
ZNF462 − 1.232013 0.000111 Down
VPRBP − 1.230287 0.00078 Down
RALGAPA1 − 1.229069 0.001804 Down
UPRT − 1.229057 0.002852 Down
UBE2W − 1.228348 0.000785 Down
SAMD4B − 1.227886 0.000667 Down
MTRNR2L4 − 1.224725 0.00172 Down
SEC24A − 1.224506 0.000421 Down
AMMECR1L − 1.222428 0.00047 Down
PRKAA2 − 1.221814 0.003029 Down
ACTN1 − 1.218558 0.000623 Down
OSBP − 1.217315 0.001464 Down
VLDLR − 1.216913 0.000239 Down
MSI2 − 1.211676 0.000731 Down
MSN − 1.209973 0.002842 Down
LRRC58 − 1.209927 0.000273 Down
COL4A5 − 1.209539 0.000317 Down
SLAIN2 − 1.207964 0.002094 Down
NDFIP1 − 1.206718 0.001932 Down
PPP2R5B − 1.20442 0.001134 Down
VPS25 − 1.20254 0.00079 Down
CPD − 1.201293 0.002626 Down
COLEC12 1.200894 0.00173 Up
THBS3 1.201895 0.000726 Up
KITLG 1.202163 0.000337 Up
SETBP1 1.202182 0.000765 Up
LOXL1 1.202879 0.001203 Up
PRKD1 1.20361 9.10E−05 Up
ZFP36L1 1.203909 0.001755 Up
EDDM3B 1.205244 0.001159 Up
ANGPT1 1.207484 0.001346 Up
MMP2 1.208515 0.000165 Up
FAM170B 1.210029 0.000923 Up
LELP1 1.213262 0.002473 Up
IGFBP4 1.215597 0.002011 Up
STC1 1.217133 0.000928 Up
EPHA7 1.218188 0.000568 Up
PRDM6 1.219262 0.000618 Up
ACTRT1 1.219685 0.001509 Up
XDH 1.222067 0.000209 Up
OR4D11 1.224206 0.000874 Up
HOXA11 1.22653 0.002001 Up
PAK3 1.228895 0.000381 Up
BNC2 1.242835 0.000303 Up
SLC16A2 1.248637 0.000593 Up
NRN1 1.251496 0.000564 Up
GDPD2 1.251704 0.000189 Up
RUNX1T1 1.251964 0.000352 Up
PCDH18 1.252101 0.000263 Up
PCDH9 1.255458 0.001848 Up
MMP16 1.25842 0.000155 Up
PRRX1 1.259453 0.001144 Up
LRP1 1.263799 0.000997 Up
SEMA5A 1.267548 7.10E−05 Up
PBX1 1.270348 0.000185 Up
RDH10 1.271163 6.60E−05 Up
VCAN 1.277158 0.000121 Up
HOXB8 1.284619 0.00016 Up
FOXG1 1.287872 0.001824 Up
MT1G 1.289954 0.000485 Up
SOCS3 1.291472 0.002252 Up
TBX4 1.309269 0.00017 Up
ADAMTS15 1.313557 0.000278 Up
FGF7 1.320284 0.000805 Up
HOXA5 1.322982 0.00144 Up
MME 1.331844 0.00015 Up
DBC1 1.332864 8.10E−05 Up
ZEB2 1.333152 0.000249 Up
LTBP1 1.335297 0.00018 Up
BTG1 1.338416 0.00112 Up
MT1H 1.346673 0.000327 Up
UGCG 1.347608 9.60E−05 Up
TCF4 1.350209 0.000559 Up
MEIS1 1.358188 0.000445 Up
BHLHE22 1.358601 0.00014 Up
MT1B 1.367849 0.000539 Up
TSHZ1 1.396499 0.000106 Up
FGF10 1.434899 5.00E−04 Up
ARRDC3 1.438034 0.000194 Up
FIGN 1.458516 0.000253 Up
NR2F2 1.464969 0.000549 Up
ZNF521 1.487048 0.000283 Up
GPM6B 1.570568 7.60E−05 Up
HOXB5 1.727273 5.70E−05 Up
FRMD5 1.736738 6.20E−05 Up
SFRP2 1.894966 0.000116 Up
Gene symbol Fold change p-value Gene feature
(E) Genes up/down-regulated in purified TCsSV40 compared with purified primary lung TCs
COL3A1 2.033893 5.20E−05 Up
FST 1.763096 5.70E−05 Up
SLIT3 1.476233 6.20E−05 Up
COL1A1 1.754216 6.60E−05 Up
FRMD5 1.529829 7.10E−05 Up
FBN1 1.662323 7.60E−05 Up
ZFP36L1 1.546307 8.10E−05 Up
TNC 1.410268 8.60E−05 Up
PCDH7 1.75739 9.10E−05 Up
DBC1 1.550832 9.60E-05 Up
MMP2 1.365924 0.000101 Up
NNAT 1.470003 0.000106 Up
STAT3 1.55145 0.000111 Up
KLHDC10 − 1.299299 0.000116 Down
KIAA1199 1.437971 0.000121 Up
BHLHE22 1.541751 0.000126 Up
SPRY2 1.451741 0.00013 Up
LOXL1 1.602346 0.000135 Up
TSHZ1 1.635298 0.00014 Up
COL5A2 1.534133 0.000145 Up
HOXA2 1.907531 0.00015 Up
FGF10 1.384277 0.000155 Up
COL12A1 1.291331 0.00016 Up
ZNF503 1.448549 0.000165 Up
NID1 1.254112 0.00017 Up
NFIX 1.50204 0.000175 Up
ANGPTL7 1.516574 0.00018 Up
COL1A2 1.516627 0.000185 Up
IGFBP7 1.527419 0.000189 Up
MEIS1 1.661917 0.000194 Up
ILDR2 1.354674 0.000199 Up
IER5L 1.407578 0.000204 Up
HMGCS1 1.325093 0.000209 Up
CALM3 1.256977 0.000214 Up
CELF2 1.661174 0.000219 Up
PCDH10 1.601334 0.000224 Up
NDST1 1.200203 0.000229 Up
CPXM1 1.387893 0.000234 Up
PPARGC1A − 1.43313 0.000239 Down
ZEB2 1.389745 0.000244 Up
SPRR1B − 1.417133 0.000249 Down
MMP16 1.351496 0.000253 Up
RNF150 1.301929 0.000258 Up
LOX 1.275704 0.000263 Up
CBX6 1.291217 0.000273 Up
ZNF521 1.642922 0.000278 Up
MME 1.32368 0.000283 Up
GDPD2 1.247925 0.000288 Up
FMR1 1.627765 0.000293 Up
PDGFRA 1.21296 0.000298 Up
C3orf58 1.227127 0.000303 Up
SFRP2 2.026877 0.000308 Up
FBLN2 1.287435 0.000313 Up
CYP51A1 1.229665 0.000317 Up
ARF6 1.234812 0.000322 Up
RBPJ − 1.345805 0.000327 Down
GPM6B 1.420512 0.000332 Up
NFIA 1.616514 0.000337 Up
MBD6 − 1.277385 0.000342 Down
EXT1 1.446781 0.000347 Up
MID2 − 1.366576 0.000352 Down
LRP6 1.5391 0.000357 Up
BICC1 1.448877 0.000362 Up
WT1 1.215831 0.000367 Up
CHD3 1.226874 0.000372 Up
THBS1 1.572993 0.000377 Up
UPRT − 1.413812 0.000381 Down
NLGN2 1.224543 0.000386 Up
NXN 1.274044 0.000391 Up
MED12 − 1.307768 0.000396 Down
LRP1 1.46219 0.000401 Up
HOXB5 1.333689 0.000406 Up
KLF7 1.264161 0.000411 Up
ACLY 1.361581 0.000416 Up
RDH10 1.355596 0.000421 Up
DPYSL2 1.315251 0.000431 Up
PRRX1 1.553947 0.000436 Up
LPHN2 1.258686 0.00044 Up
GATA6 1.43309 0.000445 Up
CDH11 1.32449 0.00045 Up
PRG4 1.243068 0.000455 Up
PCDH17 − 1.543509 0.00046 Down
NFIB 1.600764 0.000465 Up
VCAN 1.21944 0.00047 Up
FAM98A 1.298444 0.000475 Up
EFEMP1 1.226158 0.00048 Up
FOXP2 1.205803 0.000485 Up
PCDHGC5 1.331799 5.00E−04 Up
THBS2 1.266764 0.000504 Up
HIF1A 1.440204 0.000509 Up
IGFBP4 1.30241 0.000514 Up
MARK1 1.233597 0.000519 Up
KMT2D − 1.200632 0.000524 Down
SCD 1.32132 0.000534 Up
LPCAT3 1.43367 0.000539 Up
TBPL1 − 1.393924 0.000544 Down
PDE1A 1.230559 0.000554 Up
GRIA3 1.359144 0.000564 Up
EFEMP2 1.222385 0.000568 Up
TCF20 − 1.318507 0.000573 Down
PDE7B 1.556907 0.000578 Up
HTRA1 − 1.270642 0.000583 Down
HOXA5 1.58066 0.000593 Up
CYB5R1 − 1.258022 0.000603 Down
SETBP1 1.318692 0.000608 Up
CACNA1C 1.265093 0.000613 Up
ADAMTS2 1.224627 0.000618 Up
DOCK9 − 1.215588 0.000623 Down
OGT − 1.564357 0.000632 Down
COLEC12 1.376494 0.000637 Up
ZBTB18 − 1.778186 0.000642 Down
KITLG 1.25933 0.000647 Up
GFPT2 1.276106 0.000652 Up
GABRA3 1.435938 0.000657 Up
SLC16A2 1.320833 0.000662 Up
PCDHB1 − 1.242627 0.000667 Down
EPHA7 1.315288 0.000677 Up
SLCO3A1 1.220403 0.000682 Up
DDX26B − 1.214763 0.000687 Down
SEMA3D 1.235461 0.000692 Up
ADAMTS15 1.389205 0.000696 Up
MAN1A1 1.226513 0.000701 Up
TCF7L2 1.319781 0.000706 Up
PBX3 1.27527 0.000711 Up
SLIT2 1.356085 0.000721 Up
TENM4 − 1.247945 0.000731 Down
PARP6 − 1.252561 0.000736 Down
KLF9 1.320073 0.000755 Up
IGF1 1.441883 0.00076 Up
HOXB8 1.273005 0.00077 Up
ARID5B 1.28496 0.000775 Up
PKM 1.322278 0.00078 Up
BMP1 1.215932 0.000785 Up
PCDH19 − 1.416186 0.000795 Down
FEZ1 − 1.257686 8.00E−04 Down
NPR2 − 1.26446 0.00081 Down
STRBP − 1.352471 0.000819 Down
DNAJC1 1.241378 0.000824 Up
WNK1 − 1.574397 0.000829 Down
DHCR24 1.236232 0.000844 Up
EGR1 − 1.325378 0.000849 Down
MT1M 1.25661 0.000864 Up
AKAP8L − 1.20015 0.000874 Down
ATP1B1 1.211897 0.000879 Up
GATM 1.291347 0.000883 Up
TRBV6-8 − 1.35926 0.000893 Down
FZD8 1.649274 0.000903 Up
AHCYL2 − 1.206907 0.000913 Down
PPP3CA 1.344731 0.000918 Up
SURF4 1.211797 0.000923 Up
CCND2 − 1.224408 0.000938 Down
RAB11B 1.26997 0.000943 Up
FHL1 1.202305 0.000952 Up
TOX 1.397482 0.000957 Up
FOXC1 1.242409 0.000967 Up
AIDA 1.274415 0.000977 Up
TNFAIP1 1.202941 0.000982 Up
THBS3 1.214669 0.000987 Up
CLMP 1.294055 0.000992 Up
DOCK3 − 1.231871 0.001002 Down
DDIT3 − 1.40635 0.001006 Down
GPC6 1.248637 0.001011 Up
ABCB7 − 1.307951 0.001016 Down
ETV6 1.353185 0.001026 Up
CHKA − 1.240302 0.001051 Down
R3HDM2 − 1.252354 0.001061 Down
TLN1 1.226184 0.001085 Up
PFN1 1.394161 0.00109 Up
ADAMTS4 1.218343 0.001095 Up
CLIP3 1.213372 0.0011 Up
ILK 1.304537 0.00111 Up
PLXDC2 1.301745 0.00113 Up
PABPC4 − 1.218394 0.001134 Down
NR2F2 1.485732 0.001174 Up
PPAP2B 1.278773 0.001189 Up
FIGN 1.399002 0.001198 Up
SPARC 1.228554 0.001223 Up
AKT3 − 1.215306 0.001233 Down
TC10000913.hg.1 − 1.44934 0.001238 Down
RHOT1 − 1.311667 0.001243 Down
NUAK1 1.245725 0.001253 Up
SOCS3 1.418689 0.001287 Up
TC02002617.hg.1 − 1.617442 0.001292 Down
TC07000141.hg.1 − 1.394869 0.001302 Down
MYO1D 1.296444 0.001307 Up
CDH2 1.216156 0.001317 Up
TCF4 1.260214 0.001321 Up
FUBP1 − 1.41599 0.001326 Down
ARRDC3 1.309616 0.001341 Up
CYGB 1.229195 0.001351 Up
TBX4 1.238548 0.001356 Up
MUT − 1.208493 0.001361 Down
MT1H 1.423387 0.001371 Up
MBTPS2 − 1.36196 0.001381 Down
RAB1B 1.221867 0.00143 Up
AZIN1 − 1.289217 0.001435 Down
CNTFR 1.224893 0.001445 Up
NRN1 1.247028 0.001449 Up
PRPF19 1.221176 0.001469 Up
HPRT1 − 1.432868 0.001484 Down
PARVA 1.248515 0.001494 Up
MSN − 1.307225 0.001499 Down
SPRR2F − 1.204892 0.001509 Down
DOCK11 − 1.249159 0.001513 Down
H3F3A 1.288991 0.001518 Up
MAP4K3 1.215421 0.001528 Up
RGL1 1.23898 0.001543 Up
PSAT1 − 1.279406 0.001572 Down
BNC1 1.24342 0.001617 Up
HNRNPUL2 1.206099 0.001622 Up
MSI2 − 1.235799 0.001627 Down
FAM71B 1.244138 0.001656 Up
SEC23A 1.252503 0.001661 Up
CNOT6L − 1.344862 0.001666 Down
CTDSP2 1.310633 0.001676 Up
FGF7 1.282848 0.001691 Up
MYH10 1.216826 0.001696 Up
EMP3 1.28252 0.00171 Up
SOX4 1.304636 0.00172 Up
NR4A3 1.23027 0.00175 Up
USP17 1.224951 0.00176 Up
LDB1 1.225476 0.001764 Up
ATF6 − 1.284147 0.001789 Down
ABI1 1.224035 0.001804 Up
P4HA3 1.256545 0.001814 Up
PTEN 1.427111 0.001838 Up
CCT2 − 1.25044 0.001843 Down
KMT2A − 1.254142 0.001848 Down
ISM1 1.407921 0.001873 Up
DEFB113 − 1.306901 0.001878 Down
EFNA5 1.216599 0.001942 Up
RBP1 1.223532 0.002006 Up
HSPA9 − 1.22658 0.002015 Down
TRBV21OR9-2 − 1.275752 0.002035 Down
JHDM1D − 1.22599 0.002089 Down
PRKAA2 − 1.288077 0.002109 Down
GPC3 1.209065 0.002129 Up
INTS5 1.218441 0.002158 Up
EPT1 − 1.215737 0.002163 Down
PAK3 1.209358 0.002178 Up
SARS − 1.377121 0.002183 Down
MYL9 1.215861 0.002202 Up
CALR 1.328144 0.002217 Up
PLK1 1.234092 0.002222 Up
PDIA3 1.320796 0.002247 Up
C14orf1 1.234254 0.002266 Up
PRELID1 1.300632 0.002281 Up
TC01001567.hg.1 − 1.230659 0.002301 Down
SULF1 1.211791 0.002326 Up
CPSF6 − 1.256973 0.00234 Down
NR4A2 1.213443 0.002345 Up
NR1D1 − 1.219622 0.00235 Down
RAB5C 1.222135 0.002375 Up
REXO2 1.290263 0.002399 Up
LMO4 1.200112 0.002409 Up
GPR174 1.216642 0.002414 Up
AP2S1 1.217261 0.002419 Up
DYNLL2 1.251735 0.002449 Up
HUWE1 − 1.260641 0.002468 Down
VPRBP − 1.26699 0.002473 Down
BMPR1A 1.33189 0.002478 Up
DIO3 1.203031 0.002493 Up
TM9SF4 1.216029 0.002547 Up
RAB1A 1.410474 0.002572 Up
CEBPB 1.214692 0.002577 Up
ACTR1A 1.216125 0.002606 Up
LOC100509638 − 1.209083 0.002611 Down
CHMP4B 1.224858 0.002636 Up
ARHGAP1 1.325099 0.00265 Up
HMGA1 − 1.240781 0.002655 Down
TOP1 1.272427 0.00267 Up
EGR3 − 1.295132 0.002675 Down
C9orf172 1.228614 0.002685 Up
ID3 1.245858 0.002695 Up
CD248 1.388851 0.0027 Up
FAM168B 1.234437 0.002768 Up
RCN3 1.226194 0.002783 Up
MT1A 1.288399 0.002798 Up
EIF4B − 1.207714 0.002803 Down
GTPBP2 − 1.208847 0.002813 Down
TMSB10 1.386714 0.002847 Up
GABARAP 1.284343 0.002852 Up
IGHV3-38 − 1.236566 0.002916 Down
TC11000974.hg.1 − 1.267039 0.002931 Down
RAB39B − 1.258083 0.002985 Down
MMP14 1.257854 0.003034 Up
NFAT5 − 1.270263 0.003069 Down
LCE3D − 1.208922 0.003093 Down
TMTC2 1.248958 0.003108 Up
USP12 1.408625 0.003133 Up
ANKRD1 − 1.219365 0.003152 Down
RBBP5 − 1.210453 0.003172 Down
PTMA 1.251584 0.003197 Up
ACTA1 1.225395 0.003246 Up
RNF141 − 1.205359 0.00333 Down
FGFBP1 − 1.200483 0.003364 Down
RPL4 − 1.217294 0.003408 Down
CASK − 1.354502 0.003413 Down
LCE3E − 1.213158 0.003453 Down
EPC2 1.261066 0.003467 Up
NOXRED1 − 1.234805 0.003507 Down
MT1B 1.263775 0.003517 Up
CCR7 − 1.260932 0.003561 Down
BRAF − 1.278428 0.003595 Down
RPS27 − 1.246149 0.0036 Down
HNRNPH2 1.328316 0.00361 Up
IGHV2-26 − 1.203819 0.00364 Down
DEFB115 − 1.226413 0.003679 Down
PTBP2 − 1.331489 0.003763 Down
RPS6KB1 1.216347 0.003896 Up
MT2A 1.290212 0.003935 Up
TARDBP − 1.205193 0.003969 Down
SYT11 1.24811 0.004014 Up
MT1F 1.263703 0.004024 Up
SFRP1 1.245684 0.004053 Up
SEMA3A − 1.202169 0.004073 Down
TC14000204.hg.1 1.20508 0.004122 Up
TSC22D2 − 1.302317 0.004127 Down
KCNJ2 1.282504 0.004176 Up
SPTLC2 1.242016 0.004309 Up
POLA1 − 1.263183 0.004373 Down
HIPK3 1.207585 0.004398 Up
HIST2H2AA4 1.242261 0.004407 Up
TEAD1 1.201058 0.004432 Up
FBXO33 1.217546 0.004471 Up
ENOX2 − 1.227983 0.00453 Down
OR5A2 − 1.31152 0.00455 Down
THOC2 − 1.305497 0.004555 Down
CAPN6 − 1.245443 0.004614 Down
ZNF281 1.297079 0.004624 Up
NFKBIA 1.21647 0.004649 Up
TBC1D19 − 1.208949 0.004683 Down
TC03000927.hg.1 − 1.21805 0.004688 Down
EDDM3B 1.206252 0.004693 Up
TC19000375.hg.1 − 1.233615 0.004703 Down
OR5AU1 − 1.225907 0.004752 Down
PSMA3 1.210788 0.004781 Up
PABPC1 − 1.24424 0.004796 Down
OR2AJ1 − 1.209642 0.004988 Down
PPIAL4A 1.303974 0.004993 Up
FIGF 1.222296 0.005082 Up
TP53INP1 − 1.227022 0.00519 Down
DNAJA2 1.20171 0.005215 Up
SAP30 1.223176 0.005254 Up
OR4F21 − 1.206284 0.005461 Down
OR1L3 − 1.211827 0.005485 Down
TBX15 1.209874 0.005638 Up
IPO7 − 1.287169 0.005751 Down
ACVR2A 1.227166 0.005889 Up
FOXG1 1.300571 0.005918 Up
AGFG1 1.205554 0.006032 Up
MURC − 1.204566 0.006169 Down
OR10D3 − 1.304006 0.006337 Down
ADAMTS5 1.212932 0.006342 Up
EID3 1.207392 0.007065 Up
MT1G 1.209678 0.007784 Up
MSANTD2 − 1.200157 0.007966 Down
KDM6A − 1.246053 0.007971 Down
DERL2 1.224813 0.008443 Up
HSPA5 1.242949 0.008561 Up
POM121L2 − 1.202141 0.009423 Down
CCIN 1.410994 0.009492 Up
TC11000975.hg.1 − 1.23782 0.009501 Down
SYNCRIP 1.202486 0.009526 Up
OR1F1 − 1.200102 0.009708 Down
TRAM1L1 1.227933 0.009723 Up
PPIAL4C 1.292198 0.009954 Up
TC11000959.hg.1 − 1.206482 0.010584 Down
KRTAP29-1 − 1.332407 0.010889 Down
TC07000218.hg.1 − 1.236963 0.011884 Down
ALX1 − 1.216059 0.012036 Down
HEXIM1 1.213559 0.012292 Up
OR10J5 − 1.31215 0.012991 Down
IGLJ4 1.339919 0.014029 Up
C10orf85 1.259314 0.014064 Up
RNF122 1.213118 0.014384 Up
PPIAL4C 1.217453 0.015481 Up
Gene symbol p-value q-value Gene feature
(F) Genes up/down-regulated in purified primary lung TCs compared with non-purified primary lung TCs
ZNF521 5.20E−05 0 Down
NFIX 6.20E−05 0 Down
ZFP36L2 0.000263 0.038653 Down
NR2F2 0.00013 0 Down
SLIT2 7.60E−05 0 Down
NFIB 0.000155 0 Down
NFAT5 0.000288 0.038653 Down
LRP6 5.70E−05 0 Down
FAM102B 0.00019 0 Down
TCF4 0.000372 0.045591 Down
HES1 0.000406 0.045591 Down
PFN1 0.000387 0.045591 Down
TSHZ1 5.00E−04 0.04939 Down
SPRY2 0.000268 0.038653 Down
CTGF 9.10E−05 0 Down
ARRDC3 0.000244 0.038653 Down
LOXL1 0.000682 0.04939 Down
NLGN2 0.000116 0 Down
ZEB2 0.00017 0 Down
CTDSP2 0.00051 0.04939 Down
FBLN5 0.000293 0.038653 Down
FRMD5 0.000342 0.045591 Down
RGL1 0.000416 0.045591 Down