Influence of gene modification in biological behaviors and responses of mouse lung telocytes to inflammation

Song, Dongli; Xu, Menglin; Qi, Ruixue; Ma, Ruihua; Zhou, Yile; Wu, Duojiao; Fang, Hao; Wang, Xiangdong

doi:10.1186/s12967-019-1870-y

Journal of Translational Medicine

Table 1 Summary of mRNA expressed preferentially in primary TCs, SV40-transformed TCs, primary lung cells, and SV40-transformed primary lung cells

From: Influence of gene modification in biological behaviors and responses of mouse lung telocytes to inflammation

Compared pairs	Up > 0	Up > 2	Down > 0
Purified TCs^SV40 vs. non-purified primary lung TCs	158	0	124
Non-purified lung TCs^SV40 vs. purified primary lung TCs	343	1	119
Non-purified lung TCs^SV40 vs. non-purified primary lung TCs	274	1	151
Purified TCs^SV40 vs. non-purified lung TCs^SV40	64	0	75
Purified TCs^SV40 vs. purified primary lung TCs	255	2	122
Purified primary lung TCs vs. non-purified primary lung TCs	0	0	23

Gene symbol or probe set ID	Fold change	p-value	Gene feature
(A) Genes up/down-regulated in purified TCs^SV40 compared with non-purified primary lung TCs
COL3A1	1.736972	5.20E−05	Up
SLIT3	1.428832	5.70E−05	Up
FST	1.757618	6.20E−05	Up
NNAT	1.428018	6.60E−05	Up
PCDH17	− 1.82768	7.10E−05	Down
KIAA1199	1.450952	7.60E−05	Up
BHLHE22	1.431489	8.10E−05	Up
KLHDC10	− 1.342675	8.60E−05	Down
CAPN6	− 1.502786	9.10E−05	Down
DBC1	1.42647	9.60E−05	Up
ANGPTL7	1.490275	0.000101	Up
FBN1	1.555173	0.000106	Up
IGFBP7	1.491186	0.000111	Up
COL5A2	1.521795	0.000116	Up
SPRR1B	− 1.653323	0.000121	Down
PCDH7	1.645697	0.000126	Up
MBD6	− 1.354523	0.000131	Down
PPARGC1A	− 1.46284	0.000135	Down
SFRP2	1.953208	0.00014	Up
UPRT	− 1.391618	0.000145	Down
BNC1	1.309024	0.00015	Up
TNC	1.396486	0.000155	Up
EGR1	− 1.562517	0.00016	Down
COL12A1	1.253525	0.000165	Up
ZFP36L1	1.413153	0.00017	Up
NFAT5	− 1.658072	0.000175	Down
GFPT2	1.261057	0.00018	Up
FOXP2	1.209035	0.000185	Up
TCF20	− 1.334035	0.00019	Down
STAT3	1.388462	0.000195	Up
GATA6	1.445955	0.000199	Up
CYP51A1	1.224699	0.000204	Up
IGF1	1.320664	0.000209	Up
COL1A1	1.467933	0.000214	Up
PCDH19	− 1.536647	0.000219	Down
VLDLR	− 1.263978	0.000224	Down
HOXA2	1.693458	0.000229	Up
OGT	− 1.620988	0.000234	Down
ANKH	− 1.252673	0.000239	Down
ZNF503	1.323818	0.000244	Up
PCDH10	1.55352	0.000249	Up
HIF1A	1.439987	0.000254	Up
TGFB1I1	1.228978	0.000259	Up
MED12	− 1.302994	0.000264	Down
FBLN2	1.27815	0.000268	Up
HMGCS1	1.267852	0.000273	Up
CPXM1	1.343796	0.000278	Up
ILDR2	1.398758	0.000283	Up
MID2	− 1.297559	0.000288	Down
SEMA3A	− 1.339824	0.000293	Down
PTGS2	− 1.251508	0.000298	Down
BICC1	1.416447	0.000303	Up
KMT2D	− 1.222378	0.000318	Down
NFIA	1.44573	0.000323	Up
SMO	− 1.262105	0.000328	Down
TMEM238	1.23793	0.000332	Up
DNAJC1	1.241613	0.000337	Up
H2AFY2	1.200548	0.000342	Up
ARF6	1.267706	0.000347	Up
ACLY	1.32049	0.000352	Up
SPRR2F	− 1.383183	0.000357	Down
SCD	1.264224	0.000362	Up
GPC4	− 1.211023	0.000367	Down
KLF9	1.351626	0.000372	Up
ITPR3	− 1.227564	0.000377	Down
CDH11	1.285389	0.000382	Up
NXN	1.291856	0.000392	Up
MMP2	1.261064	0.000397	Up
GPM6B	1.298864	0.000401	Up
GRIA3	1.443882	0.000406	Up
CCND2	− 1.243142	0.000411	Down
LOX	1.244763	0.000416	Up
MSI2	− 1.254073	0.000421	Down
FAM126A	− 1.296542	0.000426	Down
TC11000974.hg.1	− 1.348845	0.000431	Down
DOCK9	− 1.213445	0.000446	Down
TRBV21OR9-2	− 1.381268	0.000451	Down
THBS1	1.376867	0.000456	Up
PLK1	1.251123	0.000461	Up
DDX26B	− 1.339568	0.000465	Down
FRMD5	1.270501	0.00047	Up
ADAMTS15	1.347894	0.000475	Up
MBNL1	− 1.406503	0.00048	Down
AZIN1	− 1.31031	0.000485	Down
WT1	1.203106	0.00049	Up
COL1A2	1.333456	5.00E−04	Up
ISM1	1.372788	0.000505	Up
PRRX1	1.396349	0.00051	Up
IGIP	− 1.26922	0.000515	Down
TSHZ1	1.31218	0.00052	Up
TNPO3	− 1.26636	0.000525	Down
FAM98A	1.240276	0.00053	Up
HSPA5	1.505916	0.000534	Up
PRG4	1.279794	0.000539	Up
UGCG	1.205908	0.000554	Up
CDKL5	− 1.282448	0.000559	Down
HOXB8	1.214483	0.000564	Up
RDH10	1.230479	0.000569	Up
ARL6IP1	1.267388	0.000574	Up
RNF150	1.296804	0.000594	Up
TBPL1	− 1.345451	0.000598	Down
KLF7	1.240203	0.000603	Up
ID4	1.227502	0.000608	Up
MBTPS2	− 1.372487	0.000618	Down
AHCYL2	− 1.2362	0.000623	Down
C9orf172	1.232029	0.000628	Up
THBS2	1.234081	0.000633	Up
IER5L	1.31756	0.000638	Up
FZD8	1.478565	0.000643	Up
REXO2	1.287723	0.000658	Up
MAN1A1	1.214421	0.000663	Up
PLXDC2	1.315137	0.000677	Up
DPYSL2	1.20111	0.000682	Up
INTS5	1.320636	0.000687	Up
ABCB7	− 1.288423	0.000692	Down
C3orf58	1.21307	0.000712	Up
FAM218A	1.35927	0.000717	Up
FMR1	1.401071	0.000722	Up
PCDHGC5	1.328006	0.000731	Up
TRPS1	− 1.275263	0.000736	Down
GPC6	1.24421	0.000741	Up
TC07000141.hg.1	− 1.446989	0.000771	Down
SEC23A	1.295262	0.000776	Up
ZDHHC15	− 1.240478	0.000786	Down
SMAD7	1.261408	0.000791	Up
GPC3	1.218435	0.000796	Up
TUBB4B	1.245339	0.00081	Up
TXNIP	1.202009	0.00082	Up
FIGN	1.385827	0.000825	Up
TC02002617.hg.1	− 1.775002	0.00084	Down
DTNA	− 1.217215	0.00085	Down
MEIS1	1.369642	0.000855	Up
PLK2	− 1.202425	0.00086	Down
RBPJ	− 1.218305	0.000864	Down
NPR2	− 1.309717	0.000869	Down
NID1	1.228805	0.000874	Up
AKT3	− 1.201507	0.000879	Down
SAT1	− 1.219609	0.000884	Down
SURF4	1.201325	0.000889	Up
CELF2	1.384512	0.000914	Up
ZBTB18	− 1.426169	0.000933	Down
TOX	1.381994	0.000938	Up
DACT1	1.205543	0.000943	Up
CASK	− 1.472338	0.000958	Down
KITLG	1.267156	0.000963	Up
KMT2A	− 1.28931	0.000968	Down
TRBV6-8	− 1.402432	0.000973	Down
PARP6	− 1.228703	0.000983	Down
CLMP	1.252655	0.001007	Up
EGR3	− 1.348087	0.001017	Down
PCDHB1	− 1.305233	0.001022	Down
TC10000913.hg.1	− 1.441636	0.001037	Down
TC01001567.hg.1	− 1.297173	0.001066	Down
SLC16A2	1.240464	0.001081	Up
COLEC12	1.203956	0.001096	Up
PAPD5	− 1.251764	0.001101	Down
GABRA3	1.355514	0.001116	Up
LPCAT3	1.334572	0.001126	Up
FAM102B	− 1.249464	0.00113	Down
CALR	1.210971	0.00115	Up
CNTFR	1.207485	0.00116	Up
HUWE1	− 1.286372	0.001165	Down
LOXL1	1.3066	0.00117	Up
JHDM1D	− 1.223213	0.00119	Down
HPRT1	− 1.395397	0.001209	Down
HOXC8	1.24955	0.001214	Up
DOCK11	− 1.266513	0.001234	Down
R3HDM2	− 1.226605	0.001278	Down
TRAM1L1	1.237032	0.001283	Up
POLA1	− 1.316949	0.001288	Down
VPS35	− 1.217861	0.001298	Down
CALU	− 1.289373	0.001323	Down
CD248	1.327827	0.001347	Up
THOC2	− 1.388434	0.001377	Down
UCP2	1.214025	0.001387	Up
ETV6	1.275435	0.001396	Up
AP2S1	1.218648	0.001411	Up
PIAS1	− 1.266045	0.001475	Down
TFAP2A	− 1.207326	0.00149	Down
IGFBP4	1.208644	0.0015	Up
DDIT3	− 1.300464	0.001515	Down
PRR9	− 1.306757	0.001529	Down
LRP1	1.262418	0.001539	Up
EPHA7	1.222492	0.001549	Up
GATM	1.233004	0.001594	Up
MSN	− 1.260531	0.001598	Down
P4HA3	1.253025	0.001623	Up
TAF10	1.23132	0.001628	Up
PDE7B	1.265724	0.001643	Up
KLHL13	1.21332	0.001658	Up
ATP11C	− 1.236782	0.001746	Down
HIST1H4L	1.225746	0.001761	Up
JMJD1C	− 1.223153	0.001766	Down
WNK1	− 1.347429	0.001791	Down
ATP6AP2	− 1.265769	0.001815	Down
TRBV10-1	− 1.203962	0.001855	Down
SRPX	1.225977	0.001864	Up
FGF7	1.217304	0.001909	Up
TMTC2	1.228712	0.001914	Up
MYO1D	1.22793	0.001948	Up
SARS	− 1.329997	0.001968	Down
STRBP	− 1.209603	0.002002	Down
SOX4	1.201564	0.002017	Up
EGR2	− 1.203287	0.002022	Down
LCE1D	− 1.216676	0.002047	Down
MED14	− 1.219439	0.002076	Down
OR10P1	− 1.236803	0.002086	Down
EXT1	1.244359	0.002091	Up
SOCS3	1.34295	0.002101	Up
CPSF6	− 1.214996	0.00216	Down
PKM	1.208686	0.00218	Up
FOSB	− 1.203628	0.002293	Down
TRAPPC1	1.301019	0.002318	Up
SPRR2B	− 1.274955	0.002323	Down
EMX2	1.278187	0.002396	Up
TOP1	1.225449	0.002401	Up
TBC1D19	− 1.224248	0.002406	Down
PTCHD1	− 1.206554	0.002431	Down
CDH2	1.221089	0.002441	Up
SPTLC2	1.254554	0.00252	Up
PCBP2	− 1.289738	0.002534	Down
IGKV1D-8	− 1.227643	0.002549	Down
TC03000927.hg.1	− 1.274058	0.002569	Down
TC13000014.hg.1	− 1.205937	0.002633	Down
BRAF	− 1.234126	0.002648	Down
CNOT6L	− 1.272615	0.002658	Down
PAN3	− 1.295252	0.002707	Down
SETBP1	1.224547	0.002712	Up
SPRR1A	− 1.236736	0.002717	Down
TXLNG	− 1.205245	0.002726	Down
TSC22D2	− 1.307114	0.002761	Down
ATF3	− 1.205287	0.002776	Down
FUBP1	− 1.224805	0.002781	Down
DNAJC30	1.22357	0.002825	Up
RCN3	1.218967	0.002879	Up
AGFG1	1.246198	0.002884	Up
HNRNPA3	1.23159	0.002919	Up
SRPK2	− 1.200287	0.002943	Down
ATRX	− 1.226812	0.002978	Down
ADAMTS6	− 1.248056	0.002983	Down
RAB1A	1.34731	0.003022	Up
IGKV3− 11	− 1.238746	0.003121	Down
OR4C6	1.227941	0.003145	Up
XBP1	1.202697	0.00316	Up
MURC	− 1.350099	0.003189	Down
SNX12	− 1.22367	0.003209	Down
TC11000975.hg.1	− 1.332179	0.003239	Down
HOXA5	1.302985	0.003268	Up
RBP1	1.216422	0.003396	Up
TC19000375.hg.1	− 1.216419	0.003406	Down
KDM6A	− 1.327135	0.003505	Down
TC06001136.hg.1	− 1.438272	0.003628	Down
CAV1	− 1.206156	0.003643	Down
ACSL4	1.257627	0.003682	Up
LRP6	1.211757	0.00379	Up
HIST1H1B	1.245633	0.004096	Up
DEFB136	− 1.244558	0.00415	Down
FBXO33	1.239768	0.004229	Up
TANC2	− 1.233366	0.004303	Down
USP12	1.334372	0.004475	Up
OR5A2	− 1.287342	0.004539	Down
TC18000270.hg.1	1.23255	0.004657	Up
OR51L1	− 1.224446	0.004948	Down
OR51B6	− 1.256007	0.004992	Down
PTEN	1.249442	0.005116	Up
TMSB10	1.251421	0.005327	Up
VEZF1	− 1.29591	0.005436	Down
NFIB	1.220599	0.0055	Up
CCDC166	1.217336	0.005529	Up
STAG2	− 1.224684	0.005933	Down
PIAS2	− 1.200256	0.00648	Down
ZSWIM6	1.222542	0.00651	Up
ZNF281	1.209366	0.006697	Up
SYT11	1.201281	0.00682	Up
SCXA	− 1.222753	0.007815	Down
ALX1	− 1.230342	0.007992	Down
EFNA5	1.202225	0.008702	Up
MGC15705	1.234392	0.009229	Up
GPR174	1.246926	0.009317	Up
TC09000877.hg.1	− 1.325127	0.010825	Down
KRTAP19-4	1.262139	0.010972	Up
OR52N2	1.201364	0.011977	Up

Gene symbol	Fold change	p-value	Gene feature
(B) Genes up/down-regulated in non-purified lung TCs^SV40 compared with purified primary lung TCs
COL1A1	2.030789	5.20E−05	Up
COL1A2	1.647326	5.70E−05	Up
SYVN1	1.520112	6.20E−05	Up
COL12A1	1.390303	6.60E−05	Up
MYH10	1.517922	7.10E−05	Up
ACTA1	1.453697	7.60E−05	Up
SLIT3	1.501818	8.10E−05	Up
COL3A1	1.756169	8.60E−05	Up
FBN1	1.641521	9.10E−05	Up
COL5A2	1.737694	9.60E−05	Up
GATA6	1.796826	0.000101	Up
IGFBP7	1.641817	0.000106	Up
SEMA3D	1.437537	0.000111	Up
ANGPTL7	1.811625	0.000116	Up
MEIS2	1.53255	0.000121	Up
THBS1	1.678925	0.000125	Up
HS6ST2	1.220779	0.00013	Up
BICC1	1.50068	0.000135	Up
MED12	− 1.428542	0.00014	Down
HSPA5	1.887927	0.000145	Up
PFN1	1.558653	0.00015	Up
PPARGC1A	− 1.432059	0.000155	Down
NFIB	1.535713	0.00016	Up
RBPJ	− 1.376913	0.000165	Down
ACTN1	1.37672	0.00017	Up
EXT1	1.57285	0.000175	Up
TNC	1.293769	0.00018	Up
PCDH7	1.762644	0.000185	Up
TXNIP	1.299338	0.000189	Up
LPCAT3	1.43629	0.000194	Up
COL4A5	1.312681	0.000199	Up
NUAK1	1.412387	0.000204	Up
ATP1A1	1.303558	0.000209	Up
WT1	1.363849	0.000214	Up
MASP1	− 1.206501	0.000219	Down
VCL	1.617321	0.000224	Up
IER5L	1.262549	0.000229	Up
MYO1D	1.463161	0.000234	Up
PLOD2	1.269697	0.000239	Up
FOXP2	1.290662	0.000244	Up
ATP1B1	1.344335	0.000248	Up
KRTAP29-1	− 1.332419	0.000253	Down
ITGAV	1.294132	0.000258	Up
CPXM1	1.343008	0.000263	Up
FST	1.55845	0.000268	Up
CTGF	1.578183	0.000273	Up
HMGCS1	1.228293	0.000278	Up
PLXDC2	1.295572	0.000288	Up
LOXL1	1.332093	0.000293	Up
TM9SF4	1.351928	0.000298	Up
GGCX	1.265383	0.000303	Up
INPPL1	1.32131	0.000308	Up
DUSP6	1.275474	0.000312	Up
NFIA	1.675759	0.000317	Up
GRIA3	1.592221	0.000322	Up
LTBP1	− 1.275386	0.000332	Down
BNC1	1.391268	0.000337	Up
FEZ1	− 1.275203	0.000342	Down
OGT	− 1.599369	0.000347	Down
NXN	1.203178	0.000352	Up
HIST1H2BM	1.309386	0.000357	Up
APH1A	1.273537	0.000362	Up
TMEM259	1.230715	0.000371	Up
THBS2	1.232906	0.000376	Up
ANXA6	1.256028	0.000381	Up
CDH2	1.2585	0.000391	Up
SEC23A	1.343492	0.000401	Up
NNAT	1.433848	0.000406	Up
EMX2	1.295739	0.000411	Up
VCAM1	1.215258	0.000416	Up
DNAJC1	1.413451	0.000421	Up
PCDH19	− 1.490493	0.000426	Down
ILDR2	1.412592	0.000431	Up
DOCK3	− 1.218811	0.000445	Down
DEFB128	− 1.253647	0.00045	Down
ERO1L	1.201323	0.00046	Up
CRYBA1	− 1.209259	0.000465	Down
CELF2	1.399193	0.000475	Up
ZNF503	1.316826	0.00048	Up
TM9SF3	1.337447	0.000485	Up
PTPRD	1.337777	0.000494	Up
IGHV3-43	− 1.352419	0.000499	Down
KIAA1199	1.358808	0.000509	Up
NPR2	− 1.233749	0.000514	Down
SLC7A2	1.219152	0.000519	Up
TRBV21OR9-2	− 1.26885	0.000524	Down
TCF7L2	1.344321	0.000534	Up
SRPX	1.275048	0.000549	Up
TUBG1	1.240509	0.000554	Up
TNFAIP1	1.207721	0.000558	Up
KCNAB1	1.21542	0.000563	Up
ARF6	1.224098	0.000568	Up
FBXO33	1.218704	0.000573	Up
PRPF19	1.25947	0.000578	Up
RAPH1	1.350071	0.000583	Up
PDIA3	1.527168	0.000593	Up
PBX3	1.328363	0.000598	Up
SEC23B	1.264846	0.000603	Up
GABRA3	1.405001	0.000608	Up
ARHGAP1	1.548495	0.000617	Up
AP3S1	1.293716	0.000622	Up
NFIX	1.300317	0.000627	Up
SPTLC2	1.34066	0.000632	Up
HOXC6	1.280515	0.000637	Up
RAB11B	1.318414	0.000642	Up
FHL1	1.206581	0.000652	Up
LMO4	1.222458	0.000672	Up
GBF1	1.291975	0.000677	Up
MBD6	− 1.274947	0.000681	Down
STAT3	1.346345	0.000686	Up
TLN1	1.318005	0.000691	Up
KIDINS220	1.20164	0.000696	Up
ETV6	1.300092	0.000701	Up
ATP2A2	1.245839	0.000706	Up
PARVA	1.340702	0.000711	Up
OR10D3	− 1.379974	0.000716	Down
ILK	1.411794	0.000721	Up
PLCE1	1.207815	0.000731	Up
SERPINH1	1.307929	0.000741	Up
HIF1A	1.377218	0.000745	Up
PDIA4	1.235338	0.000755	Up
MAP4K4	1.281043	0.00076	Up
REXO2	1.383088	0.000765	Up
SLC6A17	− 1.217838	0.00077	Down
PCDH17	− 1.632353	0.000775	Down
EFNA5	1.543491	0.00078	Up
LCE3E	− 1.318245	0.000785	Down
LOX	1.263793	0.00079	Up
FERMT2	1.235564	0.000795	Up
NEO1	1.379359	8.00E-04	Up
TENM3	1.236228	0.000819	Up
CDH11	1.294755	0.000824	Up
KLHDC3	1.275726	0.000829	Up
HMGA1	− 1.21677	0.000834	Down
SCD	1.277895	0.000839	Up
CCND2	− 1.222991	0.000844	Down
HES1	1.308538	0.000849	Up
PDE7B	1.38073	0.000854	Up
SPARC	1.349498	0.000864	Up
SMAD6	1.280817	0.000878	Up
SARS	− 1.260078	0.000883	Down
OSBP	1.345413	0.000903	Up
ACTR1A	1.256685	0.000913	Up
RUNX1T1	− 1.252339	0.000918	Down
TFAP2A	− 1.255715	0.000927	Down
NRG1	1.200557	0.000937	Up
HOXB5	− 1.295109	0.000942	Down
HECTD1	1.351927	0.000947	Up
LCE1C	− 1.270503	0.000952	Down
SPRED1	1.241191	0.000957	Up
PLAG1	− 1.268008	0.000967	Down
EFNB2	1.525576	0.000972	Up
HIPK3	1.37177	0.000977	Up
ID1	1.349752	0.000982	Up
GRIA4	1.321472	0.000991	Up
FAM168A	1.339626	0.001001	Up
FAM98A	1.331744	0.001006	Up
DERL2	1.375325	0.001026	Up
HSPA4	1.279904	0.001031	Up
ABCA1	1.213015	0.001036	Up
GATM	1.418597	0.001041	Up
SLC7A11	1.218849	0.001046	Up
RAB6A	1.254262	0.00105	Up
IGF1	1.369249	0.00107	Up
CCDC80	1.219878	0.00108	Up
KMT2D	− 1.206701	0.001085	Down
HOXC4	1.445692	0.00109	Up
PPP3CA	1.37054	0.001095	Up
HSPA1A	1.212978	0.0011	Up
BMPR2	1.217688	0.001105	Up
ACTG1	1.229217	0.00111	Up
ZDHHC5	1.288505	0.001114	Up
CNIH	1.285039	0.001124	Up
UNC5B	1.204984	0.001139	Up
CAPN6	− 1.418505	0.001149	Down
ZFP36L1	1.284405	0.001154	Up
FGF18	1.238166	0.001159	Up
RAB1A	1.541258	0.001164	Up
FMR1	1.333774	0.001208	Up
FAM188A	1.405263	0.001213	Up
FAM168B	1.275522	0.001228	Up
ITGB5	1.204294	0.001242	Up
KRTAP5-2	− 1.219252	0.001252	Down
FBLN5	1.287407	0.001262	Up
ACVR2A	1.403689	0.001277	Up
ADAMTS9	1.226553	0.001292	Up
NETO1	1.219365	0.001301	Up
ABI1	1.232061	0.001306	Up
INSL6	1.241028	0.001321	Up
TJP1	1.229587	0.001326	Up
HNRNPUL2	1.282031	0.001331	Up
COPG1	1.228987	0.001346	Up
COPB1	1.259033	0.001351	Up
DIO3	1.28299	0.001356	Up
DYNLL2	1.311492	0.00136	Up
DDX26B	− 1.257624	0.001365	Down
SLIT2	1.236976	0.00138	Up
GPC3	1.242766	0.001385	Up
PYGB	1.210405	0.001395	Up
MSANTD2	− 1.247787	0.001405	Down
CYGB	1.321169	0.00141	Up
GPC6	1.254278	0.001415	Up
TC08000204.hg.1	− 1.443858	0.001424	Down
STK39	1.37139	0.001429	Up
RAB1B	1.242841	0.001439	Up
ELAVL2	− 1.223928	0.001449	Down
HSP90B1	1.375708	0.001474	Up
ACTN4	1.314084	0.001483	Up
HSPA1A	1.215746	0.001503	Up
AMMECR1L	1.245785	0.001508	Up
RND3	1.239337	0.001518	Up
SPRY2	1.233483	0.001523	Up
DPYSL2	1.236003	0.001528	Up
DDB1	1.27575	0.001552	Up
SMARCA2	1.262741	0.001567	Up
HDGFRP3	1.330639	0.001572	Up
SULF1	1.221198	0.001577	Up
STK19	− 1.210825	0.001594	Down
STK19	− 1.210825	0.001594	Down
UPF2	1.267351	0.001606	Up
TRBV4-1	− 1.237852	0.001621	Down
APP	1.206738	0.001636	Up
AFF4	1.209778	0.001641	Up
MEF2A	1.213845	0.001651	Up
EDEM3	1.261632	0.001661	Up
HSPA1A	1.214617	0.001666	Up
GABRA4	1.24602	0.001675	Up
SPTAN1	1.260395	0.001685	Up
TEAD1	1.355621	0.001695	Up
WNK1	− 1.539904	0.001705	Down
LRP6	1.290518	0.00171	Up
PRRX1	1.233827	0.001749	Up
HSPA1A	1.213076	0.001759	Up
RAB8A	1.200712	0.001769	Up
STIM1	1.32461	0.001779	Up
ERLEC1	1.216094	0.001793	Up
ADRB1	1.24843	0.001803	Up
TMSB10	1.475064	0.001808	Up
ALCAM	1.207847	0.001857	Up
CYP51A1	1.220803	0.001862	Up
EGR3	− 1.357705	0.001877	Down
CDC27	1.318143	0.001887	Up
PANK3	1.23265	0.001921	Up
HOXA2	1.488536	0.001951	Up
TRBV6-8	− 1.340511	0.001971	Down
CRIM1	1.207809	0.001975	Up
LMAN1	1.205915	0.00198	Up
DEFB113	− 1.249904	0.001985	Down
FN1	1.284284	0.00199	Up
PRKG1	1.239048	0.00202	Up
TC15001075.hg.1	− 1.244805	0.002025	Down
HIST1H2BJ	1.336659	0.002074	Up
TMEM57	1.269164	0.002094	Up
USP12	1.314548	0.002118	Up
CAMK2N2	1.20406	0.002143	Up
TMTC2	1.200876	0.002162	Up
ANAPC1	1.257636	0.002167	Up
C1QL3	1.224547	0.002236	Up
KPRP	− 1.284699	0.002246	Down
PAPOLA	1.313258	0.002295	Up
ACTC1	1.2396	0.002305	Up
LCE2A	− 1.308229	0.00232	Down
CHD4	1.255055	0.002349	Up
EIF5	1.234533	0.002354	Up
PCDH10	1.328826	0.002379	Up
MYL9	1.277676	0.002404	Up
MUT	− 1.247925	0.002413	Down
MEIS1	1.223628	0.002423	Up
P2RX3	− 1.225147	0.002438	Down
UBE2M	1.345125	0.002458	Up
BMPR1A	1.384032	0.002482	Up
RAB39B	− 1.28009	0.002507	Down
MBNL2	1.267238	0.002556	Up
PLK1	1.222337	0.002561	Up
TRGV8	− 1.279773	0.002586	Down
CNN1	1.208197	0.00261	Up
ZSWIM6	1.291355	0.00265	Up
EFNB1	1.235229	0.002679	Up
MAN1A1	1.233248	0.002694	Up
HOXC8	1.264716	0.002714	Up
SMAD7	1.275196	0.002763	Up
TRIP12	1.322101	0.002778	Up
ATP2B1	1.212402	0.002812	Up
MEX3C	1.246507	0.002822	Up
SEC24A	1.225516	0.002827	Up
PSMC4	1.238673	0.002837	Up
KRTAP22-2	− 1.253194	0.002846	Down
LOC100509638	− 1.331709	0.002861	Down
KDM2A	1.21736	0.00292	Up
EIF4G2	1.346528	0.002945	Up
NOXRED1	− 1.247281	0.002964	Down
TC02002617.hg.1	− 1.384833	0.002989	Down
STT3A	1.269875	0.003009	Up
TC11000975.hg.1	− 1.273558	0.003058	Down
APOBEC1	− 1.247386	0.003063	Down
PPP2R5E	1.279695	0.003078	Up
FZD8	1.347838	0.003147	Up
HIST1H2BH	1.399643	0.003176	Up
AP1G1	1.251832	0.003191	Up
C11orf73	1.210719	0.003215	Up
RTN3	1.21898	0.00323	Up
LCE1E	− 1.222095	0.003255	Down
ADAM9	1.210498	0.00326	Up
CLINT1	1.294737	0.003294	Up
TRGV3	− 1.208645	0.003329	Down
P4HA3	1.227186	0.003388	Up
CELF1	1.215676	0.003417	Up
MAP4K5	1.258241	0.003422	Up
TARDBP	− 1.229146	0.003486	Down
BMP4	1.239271	0.003511	Up
ACTA2	1.255606	0.003525	Up
SF3B3	1.20972	0.003614	Up
DCUN1D5	1.248267	0.003634	Up
OLFML2B	1.220926	0.003643	Up
TOP1	1.254134	0.003663	Up
BTG1	− 1.348061	0.003673	Down
CALR	1.300821	0.003703	Up
H3F3A	1.228003	0.003742	Up
PUM1	1.232872	0.00383	Up
PSMA3	1.227334	0.003845	Up
OR2H2	− 1.261057	0.003865	Down
FAR1	1.284889	0.003875	Up
RC3H2	1.209665	0.003894	Up
IGKV1D-37	1.290533	0.003899	Up
EIF4B	− 1.253518	0.003949	Down
ROMO1	1.212986	0.004017	Up
NCKAP1	1.279797	0.004067	Up
HSPA2	1.241027	0.004086	Up
CPD	1.254726	0.004091	Up
NPR3	1.205107	0.004131	Up
RAP1B	1.300105	0.004165	Up
SEC62	1.322724	0.00419	Up
IGLJ4	1.46599	0.004263	Up
OR5A2	− 1.612969	0.004332	Down
IGLV6-57	1.202727	0.004342	Up
RAB21	1.224355	0.004367	Up
MMP14	1.259391	0.004465	Up
LELP1	− 1.280949	0.004475	Down
ZNF281	1.341512	0.004495	Up
KRTAP12-3	− 1.222558	0.004657	Down
MMD	1.36424	0.004691	Up
TIMP3	1.219996	0.004711	Up
ACTL8	− 1.248052	0.004746	Down
HIST1H2BE	1.383938	0.004829	Up
POLA1	− 1.226576	0.004839	Down
AIDA	1.221832	0.004854	Up
OR2H2	− 1.251288	0.004859	Down
PMP22	1.201201	0.004923	Up
KRTAP12-3	− 1.215537	0.004938	Down
SLC36A4	1.206965	0.004962	Up
SHOC2	1.224107	0.004972	Up
SOX4	1.200056	0.004977	Up
ISM1	1.253651	0.005031	Up
CSRP2	1.210735	0.005041	Up
OR4D11	− 1.307921	0.005046	Down
CAPRIN1	1.203686	0.005095	Up
PPP3R1	1.237317	0.005208	Up
PPIC	1.224048	0.005238	Up
PRAMEF10	− 1.247763	0.005257	Down
MBTPS2	− 1.210053	0.00542	Down
UBTD2	1.203269	0.00543	Up
SEC11A	1.208371	0.005449	Up
USP25	1.213603	0.005498	Up
PTMA	1.217797	0.005513	Up
FKBP1C	1.209098	0.005523	Up
ANKIB1	1.23614	0.005651	Up
GSPT1	1.233347	0.005715	Up
UCP2	1.209526	0.005735	Up
TGFB3	1.220573	0.005769	Up
HIST1H4G	1.221559	0.005803	Up
IGLJ5	− 1.226509	0.005818	Down
KIF5B	1.306336	0.005897	Up
TC10000913.hg.1	− 1.233065	0.006202	Down
TC03000927.hg.1	− 1.285309	0.006207	Down
PGRMC1	1.230418	0.006286	Up
HOXC5	1.236194	0.006291	Up
KRTAP13-4	1.202792	0.006315	Up
OR3A2	− 1.250913	0.006384	Down
SRSF6	1.240448	0.006389	Up
GTSF1L	− 1.204976	0.006532	Down
SYNCRIP	1.229937	0.006571	Up
HIST1H2BO	1.347018	0.006699	Up
EPC2	1.212558	0.006748	Up
CTDSPL2	1.229495	0.006768	Up
OR10A3	− 1.206131	0.006817	Down
KRTAP7-1	− 1.297287	0.006896	Down
THOC2	− 1.220789	0.006979	Down
ETF1	1.225052	0.006984	Up
TC11000974.hg.1	− 1.273131	0.006994	Down
PRELID1	1.210411	0.007014	Up
IGHV3-38	− 1.267673	0.007029	Down
OR1L3	− 1.275722	0.007034	Down
SRP54	1.294575	0.007117	Up
EXOC5	1.217832	0.007122	Up
OR2H2	− 1.263243	0.007292	Down
OR2H2	− 1.263243	0.007292	Down
RNF122	1.27436	0.007373	Up
PTBP2	− 1.249936	0.007644	Down
ERP44	1.208521	0.007683	Up
CCR7	− 1.217568	0.007747	Down
QKI	1.209051	0.008013	Up
ZFP42	− 1.215171	0.008141	Down
IGLV3-22	− 1.215548	0.008195	Down
DEFB103A	− 1.213104	0.008451	Down
OR3A3	− 1.258226	0.008495	Down
TOP2B	1.206659	0.008697	Up
PTEN	1.221197	0.008785	Up
IGHV3-66	− 1.226136	0.008839	Down
PPP6C	1.210188	0.008908	Up
PRAMEF8	− 1.238928	0.008923	Down
STRN3	1.291297	0.008948	Up
TC01003841.hg.1	− 1.354102	0.008997	Down
TC05001047.hg.1	− 1.208467	0.009046	Down
MAGT1	1.21942	0.00909	Up
OR2H2	− 1.252699	0.009179	Down
OR2H2	− 1.252699	0.009179	Down
OR2H2	− 1.252699	0.009179	Down
RPL4	− 1.201599	0.009336	Down
OSTC	1.203947	0.009622	Up
IKZF5	1.216696	0.009868	Up
KRTAP10-11	− 1.205771	0.009912	Down
NLK	1.209405	0.009932	Up
OR2W1	1.274304	0.009978	Up
OR2W1	1.274304	0.009978	Up
OR2W1	1.274304	0.009978	Up
OR2W1	1.274304	0.009978	Up
OR2W1	1.274304	0.009978	Up
OR2W1	1.274304	0.009978	Up
OR2W1	1.274304	0.009978	Up
OR2W1	1.274304	0.009978	Up
CD248	1.239436	0.010758	Up
HIST1H4F	1.204154	0.010876	Up
OR6C1	− 1.216993	0.010911	Down
TMEM202	− 1.213705	0.011093	Down
TP53INP1	− 1.205295	0.011329	Down
KPNA3	1.21541	0.011511	Up
C7orf66	− 1.226557	0.011919	Down
TMSB4XP4	1.260484	0.011964	Up
TRAV24	− 1.229097	0.012215	Down
WDR26	1.201142	0.012239	Up
KRTAP9-3	− 1.229216	0.012293	Down
CSNK1A1L	1.212513	0.012716	Up
TC08001202.hg.1	− 1.327872	0.013076	Down
TAS2R16	− 1.212834	0.013287	Down
IGHV1-8	1.229339	0.013312	Up
RAB2A	1.248861	0.013563	Up
GPRIN2	− 1.234909	0.014257	Down
DEFB118	− 1.270079	0.014778	Down
TC07000141.hg.1	− 1.33934	0.015	Down
TC02000056.hg.1	− 1.236353	0.015231	Down
LCE1D	− 1.234952	0.015432	Down
FAM218A	1.265433	0.015487	Up
LCE2B	− 1.208788	0.015511	Down
CRABP1	− 1.271706	0.015536	Down
OR1F1	− 1.231414	0.015841	Down
LOC100144595	− 1.207195	0.016023	Down
GALNT1	1.247945	0.016274	Up
LEP	− 1.236716	0.016746	Down
DEFB136	− 1.203294	0.017223	Down
TC07000218.hg.1	− 1.256974	0.017302	Down
PPIAL4E	1.263803	0.02144	Up
USP17	1.21594	0.026188	Up

Gene symbol	Fold change	p-value	Gene feature
(C) Genes up/down-regulated in non-purified lung TCs^SV40 compared with non-purified primary lung TCs
HSPA5	2.28735	5.20E−05	Up
BNC1	1.464673	5.70E−05	Up
CAPN6	− 1.711607	6.20E−05	Down
HOXC6	1.334235	6.60E−05	Up
COL12A1	1.349599	7.10E−05	Up
IGFBP7	1.60287	7.60E−05	Up
GATA6	1.812957	8.10E−05	Up
SLIT3	1.453596	8.60E−05	Up
ANGPTL7	1.780209	9.10E−05	Up
COL5A2	1.723719	9.60E−05	Up
COL1A1	1.699369	0.000101	Up
PPARGC1A	− 1.461747	0.000106	Down
MEIS2	1.482364	0.000111	Up
SYVN1	1.426147	0.000116	Up
MYH10	1.457796	0.000121	Up
MED12	− 1.423327	0.000126	Down
SMO	− 1.306238	0.00013	Down
DNM1	− 1.263174	0.000135	Down
ERO1L	1.270922	0.00014	Up
PBX1	− 1.307252	0.000145	Down
THBS1	1.469591	0.00015	Up
FBN1	1.535712	0.000155	Up
TRBV21OR9-2	− 1.373795	0.00016	Down
PTPRD	1.295981	0.000165	Up
BICC1	1.467091	0.00017	Up
DUSP6	1.245629	0.000175	Up
TXNIP	1.314454	0.00018	Up
FOXP2	1.294122	0.000185	Up
COL1A2	1.44837	0.00019	Up
ACTA1	1.287627	0.000195	Up
SEMA3A	− 1.310532	0.000199	Down
DES	1.335159	0.000204	Up
REXO2	1.380366	0.000209	Up
ACTN1	1.352297	0.000214	Up
VCL	1.66324	0.000219	Up
PCDH19	− 1.617275	0.000224	Down
SLC6A8	− 1.239617	0.000229	Down
PCDH17	− 1.932881	0.000239	Down
OGT	− 1.657267	0.000244	Down
HOXB5	− 1.442975	0.000249	Down
SEMA3D	1.383364	0.000254	Up
MECOM	− 1.327861	0.000259	Down
WT1	1.349575	0.000263	Up
KCNAB1	1.210026	0.000268	Up
RUNX1T1	− 1.360214	0.000273	Down
PLCE1	1.209156	0.000278	Up
COL3A1	1.499792	0.000283	Up
FAM102B	− 1.353459	0.000288	Down
MBD6	− 1.351938	0.000293	Down
CRYBA1	− 1.269111	0.000298	Down
ANXA6	1.224881	0.000303	Up
PCDH7	1.650618	0.000308	Up
PLXDC2	1.3089	0.000313	Up
FST	1.553608	0.000318	Up
NUAK1	1.27549	0.000323	Up
COL4A5	1.276706	0.000327	Up
IGF1	1.254137	0.000332	Up
SEC23A	1.389357	0.000337	Up
ATP1B1	1.276224	0.000342	Up
HS6ST2	1.230549	0.000347	Up
ZNF462	1.218491	0.000352	Up
FAM218A	1.448595	0.000357	Up
SEC23B	1.258266	0.000362	Up
PLOD2	1.25462	0.000367	Up
DNAJC1	1.413719	0.000372	Up
RAPH1	1.369576	0.000377	Up
GRIA3	1.691491	0.000382	Up
PSMC4	1.341278	0.000387	Up
SEC24A	1.317102	0.000391	Up
TGFB1I1	1.214649	0.000396	Up
ELAVL2	− 1.263137	0.000401	Down
NRP2	− 1.307128	0.000406	Down
KIAA1199	1.371075	0.000411	Up
LPHN3	− 1.212789	0.000421	Down
ARRDC3	− 1.350686	0.000426	Down
KLHL13	1.212748	0.000431	Up
MYO1D	1.385837	0.000436	Up
TM9SF3	1.307262	0.000441	Up
TFAP2A	− 1.274332	0.000446	Down
ARL6IP1	1.244781	0.000451	Up
CPXM1	1.300338	0.000455	Up
CCND2	− 1.241703	0.00046	Down
SPTLC2	1.354194	0.000465	Up
NNAT	1.392895	0.00047	Up
STK39	1.540497	0.000475	Up
ITGAV	1.267551	0.00048	Up
LTBP1	− 1.280112	0.000485	Down
CELF4	1.232625	0.00049	Up
OSBP	1.424925	0.000495	Up
MASP1	− 1.219414	5.00E−04	Down
FRMD5	− 1.36697	0.000505	Down
AP3S1	1.258065	0.00051	Up
BNC2	− 1.294519	0.000515	Down
TRPS1	− 1.34803	0.000519	Down
TUBG2	1.223767	0.000529	Up
CNN1	1.210395	0.000544	Up
TNC	1.281125	0.000549	Up
GBF1	1.314328	0.000554	Up
NFAT5	− 1.519776	0.000559	Down
NFIA	1.498716	0.000564	Up
ADAM22	1.202425	0.000584	Up
RBPJ	− 1.246466	0.000588	Down
EGR1	− 1.356633	0.000593	Down
ILDR2	1.458561	0.000603	Up
FSCN1	1.213951	0.000608	Up
VGLL3	1.201156	0.000623	Up
HIF1A	1.377011	0.000633	Up
ATP2A2	1.25653	0.000638	Up
ARF6	1.256706	0.000648	Up
NETO1	1.206084	0.000662	Up
PLK1	1.239207	0.000667	Up
CAV1	− 1.227122	0.000682	Down
ATF6	1.278798	0.000697	Up
ATP1A1	1.260299	0.000702	Up
GPC3	1.252397	0.000707	Up
HSPA4	1.310919	0.000716	Up
MAP4K4	1.293954	0.000721	Up
HOXC4	1.528822	0.000736	Up
JAG1	1.203931	0.000746	Up
INPPL1	1.248465	0.000756	Up
FOSB	− 1.204723	0.000766	Down
KMT2D	− 1.228557	0.000771	Down
PRPF19	1.227842	0.000776	Up
CCDC80	1.225889	0.00079	Up
TM9SF4	1.256719	0.000805	Up
NXN	1.219999	0.00081	Up
COPB1	1.27883	0.00082	Up
SRPX	1.337622	0.000825	Up
SMAD7	1.390506	0.00083	Up
VPS25	1.267452	0.000835	Up
TC18000270.hg.1	1.241506	0.000844	Up
DDX26B	− 1.386832	0.000854	Down
SCD	1.222675	0.000859	Up
KMT2A	− 1.233077	0.000869	Down
JUNB	− 1.289174	0.000874	Down
OR10P1	− 1.222678	0.000884	Down
LPCAT3	1.33701	0.000894	Up
ARHGAP1	1.390092	0.000909	Up
GRIA4	1.313269	0.000928	Up
GGCX	1.210524	0.000948	Up
CNIH	1.326625	0.000958	Up
SPARC	1.31356	0.000963	Up
S100A2	− 1.206393	0.000968	Down
THBS2	1.201097	0.000973	Up
MEF2A	1.231751	0.000977	Up
HOXC8	1.40158	0.000987	Up
SARS	− 1.216959	0.001002	Down
HOXC4	1.205214	0.001017	Up
FEZ1	− 1.210057	0.001022	Down
HDGFRP3	1.360953	0.001027	Up
SMAD6	1.248102	0.001032	Up
EGR3	− 1.413218	0.001037	Down
LPL	1.241889	0.001046	Up
CREB3L1	1.208352	0.001051	Up
EXT1	1.352789	0.001066	Up
SERPINH1	1.267578	0.001071	Up
CDH11	1.256532	0.001076	Up
FAM126A	− 1.231349	0.001086	Down
ZNF521	− 1.298692	0.00111	Down
PCDH18	− 1.284827	0.00113	Down
ACTN4	1.348564	0.00114	Up
C10orf53	− 1.240495	0.00115	Down
EMX2	1.428467	0.001155	Up
TUBG1	1.240367	0.001169	Up
PLAG1	− 1.253787	0.001194	Down
NEO1	1.311703	0.001209	Up
NR2F2	− 1.327418	0.001214	Down
RAB39B	− 1.208364	0.001229	Down
LCE1C	− 1.227094	0.001234	Down
NPR2	− 1.277907	0.001243	Down
APH1A	1.202275	0.001248	Up
PRR9	− 1.473668	0.001263	Down
FAM168A	1.316093	0.001273	Up
LOX	1.233141	0.001278	Up
ETV6	1.225393	0.001283	Up
MBNL1	− 1.348394	0.001312	Down
ZSWIM6	1.360747	0.001327	Up
GPM6B	− 1.209186	0.001342	Down
FERMT2	1.204761	0.001347	Up
ISM1	1.222367	0.001357	Up
HECTD1	1.325901	0.001366	Up
GPC6	1.249832	0.001371	Up
SPRR1A	− 1.304855	0.001376	Down
C17orf47	− 1.210708	0.001381	Down
POLA1	− 1.278784	0.001396	Down
RNF114	1.215485	0.001406	Up
PHLDB2	1.22064	0.001421	Up
BTG1	− 1.419463	0.001435	Down
OR2H2	− 1.386141	0.00146	Down
RAB6A	1.218989	0.00147	Up
STK19	− 1.226269	0.001482	Down
STK19	− 1.226269	0.001482	Down
EFNB1	1.214243	0.00149	Up
HIPK3	1.272379	0.001514	Up
OR2H2	− 1.336272	0.001524	Down
OR4X2	− 1.231192	0.001539	Down
ZNF503	1.203437	0.001554	Up
ABI1	1.207101	0.001568	Up
FAM188A	1.354332	0.001578	Up
MBNL2	1.315575	0.001593	Up
CDH2	1.263605	0.001618	Up
FAM98A	1.272083	0.001652	Up
DDB1	1.233239	0.001691	Up
TC11000975.hg.1	− 1.370641	0.001696	Down
DEFB128	− 1.229163	0.001701	Down
CYP51A1	1.215873	0.001706	Up
EFNA5	1.525255	0.001711	Up
CLINT1	1.352971	0.001721	Up
TCF4	− 1.350334	0.001736	Down
INTS5	1.272327	0.001741	Up
GATM	1.354506	0.00177	Up
GABRA3	1.32631	0.001775	Up
RAB1A	1.472237	0.001785	Up
TC02001150.hg.1	1.202559	0.001795	Up
CAMK2N2	1.205549	0.0018	Up
HNRNPUL2	1.26108	0.001815	Up
FGF18	1.254064	0.001829	Up
LCE3B	− 1.20559	0.001849	Down
SRPR	1.282511	0.001859	Up
RNF138	1.200216	0.001864	Up
GABRB1	1.20311	0.001869	Up
ZDHHC2	1.231848	0.001879	Up
PTGS2	− 1.235944	0.001888	Down
ANGPT1	− 1.239367	0.001923	Down
CDC27	1.301846	0.001933	Up
ZFP36L2	− 1.309184	0.001957	Down
THOC2	− 1.298345	0.001972	Down
AMMECR1L	1.204913	0.001982	Up
TAGLN	1.21811	0.001997	Up
SPRR1B	− 1.386398	0.002007	Down
ADAMTS6	− 1.251192	0.002021	Down
LCE3E	− 1.238425	0.002036	Down
TEAD1	1.316471	0.00209	Up
OR4D11	− 1.397758	0.002115	Down
PSMD14	1.269457	0.002164	Up
INSL6	1.241962	0.002169	Up
FBXO33	1.240947	0.002174	Up
OR2H2	− 1.335922	0.002211	Down
OR2H2	− 1.335922	0.002211	Down
LCE1D	− 1.24485	0.002233	Down
STIM1	1.291974	0.002253	Up
TRBV6-8	− 1.383088	0.002297	Down
PARVA	1.212507	0.002307	Up
TC11000974.hg.1	− 1.355331	0.002322	Down
CTGF	1.278251	0.002327	Up
PRKG1	1.245661	0.002341	Up
TLN1	1.209426	0.002356	Up
OR3A2	− 1.258635	0.002361	Down
NPR3	1.252907	0.002366	Up
CYGB	1.286596	0.002376	Up
ID1	1.302257	0.002396	Up
HSPA2	1.291744	0.002401	Up
DERL2	1.338707	0.002415	Up
OR2H2	− 1.331198	0.002469	Down
OR2H2	− 1.331198	0.002469	Down
OR2H2	− 1.331198	0.002469	Down
EIF4G2	1.351151	0.002548	Up
PAPOLA	1.311535	0.002578	Up
PPP3R1	1.259841	0.002588	Up
PDIA3	1.321177	0.002597	Up
HSP90B1	1.297674	0.002627	Up
EIF4A1	1.248301	0.002642	Up
TNPO3	− 1.20247	0.002676	Down
UCP2	1.245612	0.002686	Up
EEF1G	1.228255	0.00274	Up
TC13000014.hg.1	− 1.237888	0.002745	Down
TC02002617.hg.1	− 1.519734	0.00275	Down
PFN1	1.248818	0.00276	Up
ERLEC1	1.219854	0.00277	Up
GSPT1	1.296726	0.002878	Up
TC15001723.hg.1	− 1.244628	0.002883	Down
C8orf49	− 1.225571	0.002888	Down
STAT3	1.204904	0.002957	Up
MAN1A1	1.22109	0.002982	Up
ACTR1A	1.210577	0.003046	Up
TAF10	1.234009	0.003075	Up
ONECUT2	− 1.203425	0.0031	Down
PPP2R5E	1.303497	0.003105	Up
STT3A	1.268152	0.003115	Up
TC03001641.hg.1	− 1.243194	0.003134	Down
TGFB3	1.241756	0.003159	Up
DICER1	1.208135	0.003164	Up
LCE2A	− 1.356188	0.003213	Down
HIST1H4J	1.203634	0.003257	Up
P4HA1	1.268543	0.003277	Up
TCF20	− 1.200225	0.003287	Down
HOXC5	1.25077	0.003302	Up
MTX2	1.203709	0.003316	Up
MUT	− 1.206951	0.003376	Down
CPD	1.217165	0.003405	Up
PRELP	− 1.216805	0.00343	Down
OR10D3	− 1.289554	0.003558	Down
EFNB2	1.322603	0.003563	Up
MBTPS2	− 1.219406	0.003577	Down
ACVR2A	1.277435	0.003632	Up
PCDH10	1.289149	0.003641	Up
OR3A3	− 1.294084	0.003676	Down
VAT1L	1.224017	0.003681	Up
ANKIB1	1.250405	0.003705	Up
ATP6AP2	− 1.203066	0.003829	Down
TMSB10	1.33115	0.003893	Up
MYL9	1.238522	0.003976	Up
P4HA3	1.223749	0.004006	Up
LOC100144595	− 1.210771	0.004045	Down
CCDC47	1.254626	0.004085	Up
PTP4A1	1.207393	0.004104	Up
SNX12	− 1.231653	0.004163	Down
TC03000927.hg.1	− 1.34441	0.004173	Down
PRAMEF10	− 1.226358	0.004218	Down
HIST1H2BF	1.201242	0.004331	Up
HIST1H4F	1.278307	0.004355	Up
LSM2	− 1.23126	0.00436	Down
PSMC6	1.28439	0.00437	Up
TMEM57	1.214675	0.00438	Up
TRGV8	− 1.24305	0.004449	Down
SEC11A	1.212858	0.004508	Up
OR51B6	− 1.25219	0.004528	Down
ZNF830	1.223738	0.004552	Up
TMEM238	1.259086	0.004582	Up
TOP1	1.207832	0.004685	Up
LELP1	− 1.254685	0.004764	Down
MMD	1.342077	0.004774	Up
LCE1A	− 1.207411	0.004804	Down
IGKV1D-13	− 1.253243	0.004808	Down
FZD8	1.20833	0.004853	Up
OR5A2	− 1.583233	0.004887	Down
C1QL3	1.202082	0.005015	Up
PANK3	1.209123	0.00506	Up
KIF5B	1.306357	0.005094	Up
SRP54	1.335205	0.005153	Up
ETF1	1.247056	0.005385	Up
HIST1H4G	1.221559	0.005399	Up
TRIP12	1.250366	0.005463	Up
TRAJ59	1.280347	0.005591	Up
DEFB133	− 1.217544	0.00568	Down
HIST1H2BH	1.324812	0.005739	Up
ACTL8	− 1.34524	0.005828	Down
HIST1H2BO	1.331009	0.005867	Up
C16orf87	1.227019	0.005877	Up
HIST1H1B	1.236488	0.005971	Up
PPP3CA	1.2093	0.006	Up
DAZAP2	− 1.246936	0.006069	Down
C7orf66	− 1.257301	0.006168	Down
IRF2BPL	1.222737	0.006197	Up
USP12	1.245254	0.006202	Up
PGAP2	− 1.236121	0.006217	Down
WNK1	− 1.317909	0.006315	Down
FAR1	1.239903	0.006424	Up
HOXA2	1.321485	0.006497	Up
IGHV3-48	− 1.200801	0.006537	Down
LCE2C	− 1.207171	0.006714	Down
PPIC	1.208975	0.006822	Up
COPA	1.213652	0.006847	Up
SPANXN3	1.276398	0.006916	Up
DCUN1D5	1.204299	0.006931	Up
RAP1B	1.238418	0.006946	Up
CMAS	1.312695	0.007064	Up
NLK	1.232188	0.007211	Up
HIST1H2BE	1.335735	0.007216	Up
HRNR	− 1.31544	0.007221	Down
OR4A16	1.208665	0.007285	Up
C8orf48	1.252595	0.007477	Up
CSNK1A1	1.214353	0.007497	Up
UBE2M	1.219256	0.00761	Up
ZNF281	1.250794	0.007817	Up
IGHD2-21	− 1.332138	0.007837	Down
E2F3	1.206829	0.008019	Up
TC10000913.hg.1	− 1.226511	0.008108	Down
NCKAP1	1.22608	0.008285	Up
PPP6C	1.215357	0.008364	Up
SEC62	1.25965	0.008536	Up
EXOC5	1.207899	0.00862	Up
FKBP1C	1.20189	0.008787	Up
ZBTB6	1.223895	0.008964	Up
TRBV6-7	− 1.261291	0.009048	Down
DEFB136	− 1.297342	0.009122	Down
FGF10	− 1.247986	0.009186	Down
OR4C6	1.293432	0.00927	Up
GFPT1	1.20605	0.009309	Up
PSMA6	1.216218	0.009353	Up
TC01002282.hg.1	− 1.202154	0.009477	Down
KRTAP9-8	− 1.222393	0.009486	Down
LCE2B	− 1.251225	0.009595	Down
TC17000686.hg.1	− 1.224599	0.009846	Down
TMSB4XP4	1.276305	0.009935	Up
LOC100509638	− 1.228863	0.010215	Down
OR51L1	− 1.209919	0.010486	Down
TC07000141.hg.1	− 1.389386	0.011299	Down
USP17	1.231161	0.011338	Up
BMPR1A	1.225957	0.011535	Up
IGHV1OR21-1	− 1.207255	0.011811	Down
LOC728819	1.209199	0.011968	Up
WDR26	1.21391	0.012145	Up
TC15001075.hg.1	− 1.206125	0.012165	Down
TRAPPC1	1.207842	0.012264	Up
STRN3	1.251923	0.012589	Up
IGKV1D-37	1.290804	0.012667	Up
TC05000944.hg.1	− 1.209012	0.012855	Down
KRTAP6-3	− 1.209466	0.013017	Down
TC01001567.hg.1	− 1.220919	0.013106	Down
TC08000204.hg.1	− 1.257586	0.013199	Down
TRAV24	− 1.224177	0.013224	Down
KPNA3	1.208042	0.013244	Up
CALHM1	− 1.281085	0.01346	Down
KRTAP5-6	− 1.213396	0.013514	Down
OR5W2	− 1.227139	0.013682	Down
HIST2H2BE	1.203613	0.013928	Up
TAOK1	1.203131	0.014223	Up
RBMXL2	1.242693	0.014371	Up
MGC15705	1.248494	0.014499	Up
NOP58	1.210344	0.014898	Up
TC01003841.hg.1	− 1.272609	0.014947	Down
CASK	− 1.202663	0.015371	Down
GPX5	− 1.231507	0.015435	Down
IGLJ6	− 1.209384	0.015651	Down
OR6C1	− 1.220835	0.015715	Down
OR1L3	− 1.26804	0.015981	Down
IGKV1-9	− 1.205738	0.016425	Down
CSNK1A1L	1.236726	0.016981	Up
OR51A4	− 1.251899	0.017158	Down
TC07000847.hg.1	1.200866	0.017404	Up
TAS2R16	− 1.220859	0.017424	Down
EIF2S2	1.202591	0.018104	Up
RAB2A	1.218567	0.018571	Up
OR56A5	1.204074	0.022471	Up

Gene symbol	Fold change	p-value	Gene feature
(D) Genes up/down-regulated in purified TCs^SV40 compared with non-purified lung TCs^SV40
ZBTB18	− 1.554972	0.000298	Down
MID2	− 1.541494	0.000126	Down
HSPA5	− 1.518909	0.000465	Down
TSC22D2	− 1.5017	0.00048	Down
VCL	− 1.495358	0.000204	Down
MEIS2	− 1.460638	8.60E−05	Down
STK39	− 1.423681	0.000313	Down
CTGF	− 1.421299	0.000268	Down
DOCK11	− 1.415118	0.000426	Down
ATF6	− 1.409588	0.000199	Down
SLC7A11	− 1.404048	0.000101	Down
BRAF	− 1.396899	0.000755	Down
NLK	− 1.384761	0.00076	Down
ERO1L	− 1.366172	5.20E−05	Down
HIST1H2BE	− 1.360048	0.003083	Down
MEF2A	− 1.354049	0.000135	Down
CELF1	− 1.34869	0.000706	Down
HPRT1	− 1.348486	0.001415	Down
TBPL1	− 1.344601	0.000573	Down
FAM188A	− 1.344027	0.000652	Down
AZIN1	− 1.322403	0.000288	Down
SYVN1	− 1.309011	0.000145	Down
HIST1H2BO	− 1.308399	0.002104	Down
STRBP	− 1.307068	0.000362	Down
ABCB7	− 1.302327	0.00239	Down
EFNB2	− 1.298157	0.002606	Down
ANKRD1	− 1.293984	0.000455	Down
SLC6A9	− 1.292011	0.000244	Down
RND1	− 1.288509	0.000258	Down
HOXC4	− 1.286961	0.001459	Down
PGRMC1	− 1.285024	0.000775	Down
IGHV1-8	− 1.283244	0.003162	Down
GSPT1	− 1.277447	0.002286	Down
FN1	− 1.272748	0.001287	Down
AKT3	− 1.269844	0.000436	Down
STIM1	− 1.269255	0.00139	Down
EFNA5	− 1.268694	0.002818	Down
CCDC47	− 1.265588	0.001528	Down
DES	− 1.265153	0.00013	Down
PDZD8	− 1.258982	0.000696	Down
GATA6	− 1.253813	0.000637	Down
SEL1L	− 1.25119	0.000603	Down
HDGFRP3	− 1.249545	0.000947	Down
ZNF827	− 1.249169	0.000175	Down
NEO1	− 1.24814	0.001996	Down
MYH10	− 1.247444	0.00049	Down
C16orf87	− 1.247099	0.002311	Down
HES1	− 1.244124	0.000308	Down
HERPUD1	− 1.239348	0.000229	Down
DUSP6	− 1.237186	0.002138	Down
RAPH1	− 1.235005	0.000992	Down
CDC42BPA	− 1.233364	0.00203	Down
ACTN4	− 1.232684	0.00174	Down
ZNF462	− 1.232013	0.000111	Down
VPRBP	− 1.230287	0.00078	Down
RALGAPA1	− 1.229069	0.001804	Down
UPRT	− 1.229057	0.002852	Down
UBE2W	− 1.228348	0.000785	Down
SAMD4B	− 1.227886	0.000667	Down
MTRNR2L4	− 1.224725	0.00172	Down
SEC24A	− 1.224506	0.000421	Down
AMMECR1L	− 1.222428	0.00047	Down
PRKAA2	− 1.221814	0.003029	Down
ACTN1	− 1.218558	0.000623	Down
OSBP	− 1.217315	0.001464	Down
VLDLR	− 1.216913	0.000239	Down
MSI2	− 1.211676	0.000731	Down
MSN	− 1.209973	0.002842	Down
LRRC58	− 1.209927	0.000273	Down
COL4A5	− 1.209539	0.000317	Down
SLAIN2	− 1.207964	0.002094	Down
NDFIP1	− 1.206718	0.001932	Down
PPP2R5B	− 1.20442	0.001134	Down
VPS25	− 1.20254	0.00079	Down
CPD	− 1.201293	0.002626	Down
COLEC12	1.200894	0.00173	Up
THBS3	1.201895	0.000726	Up
KITLG	1.202163	0.000337	Up
SETBP1	1.202182	0.000765	Up
LOXL1	1.202879	0.001203	Up
PRKD1	1.20361	9.10E−05	Up
ZFP36L1	1.203909	0.001755	Up
EDDM3B	1.205244	0.001159	Up
ANGPT1	1.207484	0.001346	Up
MMP2	1.208515	0.000165	Up
FAM170B	1.210029	0.000923	Up
LELP1	1.213262	0.002473	Up
IGFBP4	1.215597	0.002011	Up
STC1	1.217133	0.000928	Up
EPHA7	1.218188	0.000568	Up
PRDM6	1.219262	0.000618	Up
ACTRT1	1.219685	0.001509	Up
XDH	1.222067	0.000209	Up
OR4D11	1.224206	0.000874	Up
HOXA11	1.22653	0.002001	Up
PAK3	1.228895	0.000381	Up
BNC2	1.242835	0.000303	Up
SLC16A2	1.248637	0.000593	Up
NRN1	1.251496	0.000564	Up
GDPD2	1.251704	0.000189	Up
RUNX1T1	1.251964	0.000352	Up
PCDH18	1.252101	0.000263	Up
PCDH9	1.255458	0.001848	Up
MMP16	1.25842	0.000155	Up
PRRX1	1.259453	0.001144	Up
LRP1	1.263799	0.000997	Up
SEMA5A	1.267548	7.10E−05	Up
PBX1	1.270348	0.000185	Up
RDH10	1.271163	6.60E−05	Up
VCAN	1.277158	0.000121	Up
HOXB8	1.284619	0.00016	Up
FOXG1	1.287872	0.001824	Up
MT1G	1.289954	0.000485	Up
SOCS3	1.291472	0.002252	Up
TBX4	1.309269	0.00017	Up
ADAMTS15	1.313557	0.000278	Up
FGF7	1.320284	0.000805	Up
HOXA5	1.322982	0.00144	Up
MME	1.331844	0.00015	Up
DBC1	1.332864	8.10E−05	Up
ZEB2	1.333152	0.000249	Up
LTBP1	1.335297	0.00018	Up
BTG1	1.338416	0.00112	Up
MT1H	1.346673	0.000327	Up
UGCG	1.347608	9.60E−05	Up
TCF4	1.350209	0.000559	Up
MEIS1	1.358188	0.000445	Up
BHLHE22	1.358601	0.00014	Up
MT1B	1.367849	0.000539	Up
TSHZ1	1.396499	0.000106	Up
FGF10	1.434899	5.00E−04	Up
ARRDC3	1.438034	0.000194	Up
FIGN	1.458516	0.000253	Up
NR2F2	1.464969	0.000549	Up
ZNF521	1.487048	0.000283	Up
GPM6B	1.570568	7.60E−05	Up
HOXB5	1.727273	5.70E−05	Up
FRMD5	1.736738	6.20E−05	Up
SFRP2	1.894966	0.000116	Up

Gene symbol	Fold change	p-value	Gene feature
(E) Genes up/down-regulated in purified TCs^SV40 compared with purified primary lung TCs
COL3A1	2.033893	5.20E−05	Up
FST	1.763096	5.70E−05	Up
SLIT3	1.476233	6.20E−05	Up
COL1A1	1.754216	6.60E−05	Up
FRMD5	1.529829	7.10E−05	Up
FBN1	1.662323	7.60E−05	Up
ZFP36L1	1.546307	8.10E−05	Up
TNC	1.410268	8.60E−05	Up
PCDH7	1.75739	9.10E−05	Up
DBC1	1.550832	9.60E-05	Up
MMP2	1.365924	0.000101	Up
NNAT	1.470003	0.000106	Up
STAT3	1.55145	0.000111	Up
KLHDC10	− 1.299299	0.000116	Down
KIAA1199	1.437971	0.000121	Up
BHLHE22	1.541751	0.000126	Up
SPRY2	1.451741	0.00013	Up
LOXL1	1.602346	0.000135	Up
TSHZ1	1.635298	0.00014	Up
COL5A2	1.534133	0.000145	Up
HOXA2	1.907531	0.00015	Up
FGF10	1.384277	0.000155	Up
COL12A1	1.291331	0.00016	Up
ZNF503	1.448549	0.000165	Up
NID1	1.254112	0.00017	Up
NFIX	1.50204	0.000175	Up
ANGPTL7	1.516574	0.00018	Up
COL1A2	1.516627	0.000185	Up
IGFBP7	1.527419	0.000189	Up
MEIS1	1.661917	0.000194	Up
ILDR2	1.354674	0.000199	Up
IER5L	1.407578	0.000204	Up
HMGCS1	1.325093	0.000209	Up
CALM3	1.256977	0.000214	Up
CELF2	1.661174	0.000219	Up
PCDH10	1.601334	0.000224	Up
NDST1	1.200203	0.000229	Up
CPXM1	1.387893	0.000234	Up
PPARGC1A	− 1.43313	0.000239	Down
ZEB2	1.389745	0.000244	Up
SPRR1B	− 1.417133	0.000249	Down
MMP16	1.351496	0.000253	Up
RNF150	1.301929	0.000258	Up
LOX	1.275704	0.000263	Up
CBX6	1.291217	0.000273	Up
ZNF521	1.642922	0.000278	Up
MME	1.32368	0.000283	Up
GDPD2	1.247925	0.000288	Up
FMR1	1.627765	0.000293	Up
PDGFRA	1.21296	0.000298	Up
C3orf58	1.227127	0.000303	Up
SFRP2	2.026877	0.000308	Up
FBLN2	1.287435	0.000313	Up
CYP51A1	1.229665	0.000317	Up
ARF6	1.234812	0.000322	Up
RBPJ	− 1.345805	0.000327	Down
GPM6B	1.420512	0.000332	Up
NFIA	1.616514	0.000337	Up
MBD6	− 1.277385	0.000342	Down
EXT1	1.446781	0.000347	Up
MID2	− 1.366576	0.000352	Down
LRP6	1.5391	0.000357	Up
BICC1	1.448877	0.000362	Up
WT1	1.215831	0.000367	Up
CHD3	1.226874	0.000372	Up
THBS1	1.572993	0.000377	Up
UPRT	− 1.413812	0.000381	Down
NLGN2	1.224543	0.000386	Up
NXN	1.274044	0.000391	Up
MED12	− 1.307768	0.000396	Down
LRP1	1.46219	0.000401	Up
HOXB5	1.333689	0.000406	Up
KLF7	1.264161	0.000411	Up
ACLY	1.361581	0.000416	Up
RDH10	1.355596	0.000421	Up
DPYSL2	1.315251	0.000431	Up
PRRX1	1.553947	0.000436	Up
LPHN2	1.258686	0.00044	Up
GATA6	1.43309	0.000445	Up
CDH11	1.32449	0.00045	Up
PRG4	1.243068	0.000455	Up
PCDH17	− 1.543509	0.00046	Down
NFIB	1.600764	0.000465	Up
VCAN	1.21944	0.00047	Up
FAM98A	1.298444	0.000475	Up
EFEMP1	1.226158	0.00048	Up
FOXP2	1.205803	0.000485	Up
PCDHGC5	1.331799	5.00E−04	Up
THBS2	1.266764	0.000504	Up
HIF1A	1.440204	0.000509	Up
IGFBP4	1.30241	0.000514	Up
MARK1	1.233597	0.000519	Up
KMT2D	− 1.200632	0.000524	Down
SCD	1.32132	0.000534	Up
LPCAT3	1.43367	0.000539	Up
TBPL1	− 1.393924	0.000544	Down
PDE1A	1.230559	0.000554	Up
GRIA3	1.359144	0.000564	Up
EFEMP2	1.222385	0.000568	Up
TCF20	− 1.318507	0.000573	Down
PDE7B	1.556907	0.000578	Up
HTRA1	− 1.270642	0.000583	Down
HOXA5	1.58066	0.000593	Up
CYB5R1	− 1.258022	0.000603	Down
SETBP1	1.318692	0.000608	Up
CACNA1C	1.265093	0.000613	Up
ADAMTS2	1.224627	0.000618	Up
DOCK9	− 1.215588	0.000623	Down
OGT	− 1.564357	0.000632	Down
COLEC12	1.376494	0.000637	Up
ZBTB18	− 1.778186	0.000642	Down
KITLG	1.25933	0.000647	Up
GFPT2	1.276106	0.000652	Up
GABRA3	1.435938	0.000657	Up
SLC16A2	1.320833	0.000662	Up
PCDHB1	− 1.242627	0.000667	Down
EPHA7	1.315288	0.000677	Up
SLCO3A1	1.220403	0.000682	Up
DDX26B	− 1.214763	0.000687	Down
SEMA3D	1.235461	0.000692	Up
ADAMTS15	1.389205	0.000696	Up
MAN1A1	1.226513	0.000701	Up
TCF7L2	1.319781	0.000706	Up
PBX3	1.27527	0.000711	Up
SLIT2	1.356085	0.000721	Up
TENM4	− 1.247945	0.000731	Down
PARP6	− 1.252561	0.000736	Down
KLF9	1.320073	0.000755	Up
IGF1	1.441883	0.00076	Up
HOXB8	1.273005	0.00077	Up
ARID5B	1.28496	0.000775	Up
PKM	1.322278	0.00078	Up
BMP1	1.215932	0.000785	Up
PCDH19	− 1.416186	0.000795	Down
FEZ1	− 1.257686	8.00E−04	Down
NPR2	− 1.26446	0.00081	Down
STRBP	− 1.352471	0.000819	Down
DNAJC1	1.241378	0.000824	Up
WNK1	− 1.574397	0.000829	Down
DHCR24	1.236232	0.000844	Up
EGR1	− 1.325378	0.000849	Down
MT1M	1.25661	0.000864	Up
AKAP8L	− 1.20015	0.000874	Down
ATP1B1	1.211897	0.000879	Up
GATM	1.291347	0.000883	Up
TRBV6-8	− 1.35926	0.000893	Down
FZD8	1.649274	0.000903	Up
AHCYL2	− 1.206907	0.000913	Down
PPP3CA	1.344731	0.000918	Up
SURF4	1.211797	0.000923	Up
CCND2	− 1.224408	0.000938	Down
RAB11B	1.26997	0.000943	Up
FHL1	1.202305	0.000952	Up
TOX	1.397482	0.000957	Up
FOXC1	1.242409	0.000967	Up
AIDA	1.274415	0.000977	Up
TNFAIP1	1.202941	0.000982	Up
THBS3	1.214669	0.000987	Up
CLMP	1.294055	0.000992	Up
DOCK3	− 1.231871	0.001002	Down
DDIT3	− 1.40635	0.001006	Down
GPC6	1.248637	0.001011	Up
ABCB7	− 1.307951	0.001016	Down
ETV6	1.353185	0.001026	Up
CHKA	− 1.240302	0.001051	Down
R3HDM2	− 1.252354	0.001061	Down
TLN1	1.226184	0.001085	Up
PFN1	1.394161	0.00109	Up
ADAMTS4	1.218343	0.001095	Up
CLIP3	1.213372	0.0011	Up
ILK	1.304537	0.00111	Up
PLXDC2	1.301745	0.00113	Up
PABPC4	− 1.218394	0.001134	Down
NR2F2	1.485732	0.001174	Up
PPAP2B	1.278773	0.001189	Up
FIGN	1.399002	0.001198	Up
SPARC	1.228554	0.001223	Up
AKT3	− 1.215306	0.001233	Down
TC10000913.hg.1	− 1.44934	0.001238	Down
RHOT1	− 1.311667	0.001243	Down
NUAK1	1.245725	0.001253	Up
SOCS3	1.418689	0.001287	Up
TC02002617.hg.1	− 1.617442	0.001292	Down
TC07000141.hg.1	− 1.394869	0.001302	Down
MYO1D	1.296444	0.001307	Up
CDH2	1.216156	0.001317	Up
TCF4	1.260214	0.001321	Up
FUBP1	− 1.41599	0.001326	Down
ARRDC3	1.309616	0.001341	Up
CYGB	1.229195	0.001351	Up
TBX4	1.238548	0.001356	Up
MUT	− 1.208493	0.001361	Down
MT1H	1.423387	0.001371	Up
MBTPS2	− 1.36196	0.001381	Down
RAB1B	1.221867	0.00143	Up
AZIN1	− 1.289217	0.001435	Down
CNTFR	1.224893	0.001445	Up
NRN1	1.247028	0.001449	Up
PRPF19	1.221176	0.001469	Up
HPRT1	− 1.432868	0.001484	Down
PARVA	1.248515	0.001494	Up
MSN	− 1.307225	0.001499	Down
SPRR2F	− 1.204892	0.001509	Down
DOCK11	− 1.249159	0.001513	Down
H3F3A	1.288991	0.001518	Up
MAP4K3	1.215421	0.001528	Up
RGL1	1.23898	0.001543	Up
PSAT1	− 1.279406	0.001572	Down
BNC1	1.24342	0.001617	Up
HNRNPUL2	1.206099	0.001622	Up
MSI2	− 1.235799	0.001627	Down
FAM71B	1.244138	0.001656	Up
SEC23A	1.252503	0.001661	Up
CNOT6L	− 1.344862	0.001666	Down
CTDSP2	1.310633	0.001676	Up
FGF7	1.282848	0.001691	Up
MYH10	1.216826	0.001696	Up
EMP3	1.28252	0.00171	Up
SOX4	1.304636	0.00172	Up
NR4A3	1.23027	0.00175	Up
USP17	1.224951	0.00176	Up
LDB1	1.225476	0.001764	Up
ATF6	− 1.284147	0.001789	Down
ABI1	1.224035	0.001804	Up
P4HA3	1.256545	0.001814	Up
PTEN	1.427111	0.001838	Up
CCT2	− 1.25044	0.001843	Down
KMT2A	− 1.254142	0.001848	Down
ISM1	1.407921	0.001873	Up
DEFB113	− 1.306901	0.001878	Down
EFNA5	1.216599	0.001942	Up
RBP1	1.223532	0.002006	Up
HSPA9	− 1.22658	0.002015	Down
TRBV21OR9-2	− 1.275752	0.002035	Down
JHDM1D	− 1.22599	0.002089	Down
PRKAA2	− 1.288077	0.002109	Down
GPC3	1.209065	0.002129	Up
INTS5	1.218441	0.002158	Up
EPT1	− 1.215737	0.002163	Down
PAK3	1.209358	0.002178	Up
SARS	− 1.377121	0.002183	Down
MYL9	1.215861	0.002202	Up
CALR	1.328144	0.002217	Up
PLK1	1.234092	0.002222	Up
PDIA3	1.320796	0.002247	Up
C14orf1	1.234254	0.002266	Up
PRELID1	1.300632	0.002281	Up
TC01001567.hg.1	− 1.230659	0.002301	Down
SULF1	1.211791	0.002326	Up
CPSF6	− 1.256973	0.00234	Down
NR4A2	1.213443	0.002345	Up
NR1D1	− 1.219622	0.00235	Down
RAB5C	1.222135	0.002375	Up
REXO2	1.290263	0.002399	Up
LMO4	1.200112	0.002409	Up
GPR174	1.216642	0.002414	Up
AP2S1	1.217261	0.002419	Up
DYNLL2	1.251735	0.002449	Up
HUWE1	− 1.260641	0.002468	Down
VPRBP	− 1.26699	0.002473	Down
BMPR1A	1.33189	0.002478	Up
DIO3	1.203031	0.002493	Up
TM9SF4	1.216029	0.002547	Up
RAB1A	1.410474	0.002572	Up
CEBPB	1.214692	0.002577	Up
ACTR1A	1.216125	0.002606	Up
LOC100509638	− 1.209083	0.002611	Down
CHMP4B	1.224858	0.002636	Up
ARHGAP1	1.325099	0.00265	Up
HMGA1	− 1.240781	0.002655	Down
TOP1	1.272427	0.00267	Up
EGR3	− 1.295132	0.002675	Down
C9orf172	1.228614	0.002685	Up
ID3	1.245858	0.002695	Up
CD248	1.388851	0.0027	Up
FAM168B	1.234437	0.002768	Up
RCN3	1.226194	0.002783	Up
MT1A	1.288399	0.002798	Up
EIF4B	− 1.207714	0.002803	Down
GTPBP2	− 1.208847	0.002813	Down
TMSB10	1.386714	0.002847	Up
GABARAP	1.284343	0.002852	Up
IGHV3-38	− 1.236566	0.002916	Down
TC11000974.hg.1	− 1.267039	0.002931	Down
RAB39B	− 1.258083	0.002985	Down
MMP14	1.257854	0.003034	Up
NFAT5	− 1.270263	0.003069	Down
LCE3D	− 1.208922	0.003093	Down
TMTC2	1.248958	0.003108	Up
USP12	1.408625	0.003133	Up
ANKRD1	− 1.219365	0.003152	Down
RBBP5	− 1.210453	0.003172	Down
PTMA	1.251584	0.003197	Up
ACTA1	1.225395	0.003246	Up
RNF141	− 1.205359	0.00333	Down
FGFBP1	− 1.200483	0.003364	Down
RPL4	− 1.217294	0.003408	Down
CASK	− 1.354502	0.003413	Down
LCE3E	− 1.213158	0.003453	Down
EPC2	1.261066	0.003467	Up
NOXRED1	− 1.234805	0.003507	Down
MT1B	1.263775	0.003517	Up
CCR7	− 1.260932	0.003561	Down
BRAF	− 1.278428	0.003595	Down
RPS27	− 1.246149	0.0036	Down
HNRNPH2	1.328316	0.00361	Up
IGHV2-26	− 1.203819	0.00364	Down
DEFB115	− 1.226413	0.003679	Down
PTBP2	− 1.331489	0.003763	Down
RPS6KB1	1.216347	0.003896	Up
MT2A	1.290212	0.003935	Up
TARDBP	− 1.205193	0.003969	Down
SYT11	1.24811	0.004014	Up
MT1F	1.263703	0.004024	Up
SFRP1	1.245684	0.004053	Up
SEMA3A	− 1.202169	0.004073	Down
TC14000204.hg.1	1.20508	0.004122	Up
TSC22D2	− 1.302317	0.004127	Down
KCNJ2	1.282504	0.004176	Up
SPTLC2	1.242016	0.004309	Up
POLA1	− 1.263183	0.004373	Down
HIPK3	1.207585	0.004398	Up
HIST2H2AA4	1.242261	0.004407	Up
TEAD1	1.201058	0.004432	Up
FBXO33	1.217546	0.004471	Up
ENOX2	− 1.227983	0.00453	Down
OR5A2	− 1.31152	0.00455	Down
THOC2	− 1.305497	0.004555	Down
CAPN6	− 1.245443	0.004614	Down
ZNF281	1.297079	0.004624	Up
NFKBIA	1.21647	0.004649	Up
TBC1D19	− 1.208949	0.004683	Down
TC03000927.hg.1	− 1.21805	0.004688	Down
EDDM3B	1.206252	0.004693	Up
TC19000375.hg.1	− 1.233615	0.004703	Down
OR5AU1	− 1.225907	0.004752	Down
PSMA3	1.210788	0.004781	Up
PABPC1	− 1.24424	0.004796	Down
OR2AJ1	− 1.209642	0.004988	Down
PPIAL4A	1.303974	0.004993	Up
FIGF	1.222296	0.005082	Up
TP53INP1	− 1.227022	0.00519	Down
DNAJA2	1.20171	0.005215	Up
SAP30	1.223176	0.005254	Up
OR4F21	− 1.206284	0.005461	Down
OR1L3	− 1.211827	0.005485	Down
TBX15	1.209874	0.005638	Up
IPO7	− 1.287169	0.005751	Down
ACVR2A	1.227166	0.005889	Up
FOXG1	1.300571	0.005918	Up
AGFG1	1.205554	0.006032	Up
MURC	− 1.204566	0.006169	Down
OR10D3	− 1.304006	0.006337	Down
ADAMTS5	1.212932	0.006342	Up
EID3	1.207392	0.007065	Up
MT1G	1.209678	0.007784	Up
MSANTD2	− 1.200157	0.007966	Down
KDM6A	− 1.246053	0.007971	Down
DERL2	1.224813	0.008443	Up
HSPA5	1.242949	0.008561	Up
POM121L2	− 1.202141	0.009423	Down
CCIN	1.410994	0.009492	Up
TC11000975.hg.1	− 1.23782	0.009501	Down
SYNCRIP	1.202486	0.009526	Up
OR1F1	− 1.200102	0.009708	Down
TRAM1L1	1.227933	0.009723	Up
PPIAL4C	1.292198	0.009954	Up
TC11000959.hg.1	− 1.206482	0.010584	Down
KRTAP29-1	− 1.332407	0.010889	Down
TC07000218.hg.1	− 1.236963	0.011884	Down
ALX1	− 1.216059	0.012036	Down
HEXIM1	1.213559	0.012292	Up
OR10J5	− 1.31215	0.012991	Down
IGLJ4	1.339919	0.014029	Up
C10orf85	1.259314	0.014064	Up
RNF122	1.213118	0.014384	Up
PPIAL4C	1.217453	0.015481	Up

Gene symbol	p-value	q-value	Gene feature
(F) Genes up/down-regulated in purified primary lung TCs compared with non-purified primary lung TCs
ZNF521	5.20E−05	0	Down
NFIX	6.20E−05	0	Down
ZFP36L2	0.000263	0.038653	Down
NR2F2	0.00013	0	Down
SLIT2	7.60E−05	0	Down
NFIB	0.000155	0	Down
NFAT5	0.000288	0.038653	Down
LRP6	5.70E−05	0	Down
FAM102B	0.00019	0	Down
TCF4	0.000372	0.045591	Down
HES1	0.000406	0.045591	Down
PFN1	0.000387	0.045591	Down
TSHZ1	5.00E−04	0.04939	Down
SPRY2	0.000268	0.038653	Down
CTGF	9.10E−05	0	Down
ARRDC3	0.000244	0.038653	Down
LOXL1	0.000682	0.04939	Down
NLGN2	0.000116	0	Down
ZEB2	0.00017	0	Down
CTDSP2	0.00051	0.04939	Down
FBLN5	0.000293	0.038653	Down
FRMD5	0.000342	0.045591	Down
RGL1	0.000416	0.045591	Down

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ISSN: 1479-5876

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