Table 2 List of biomarkers in this study
Marker | Origin | Type | Description | References |
|---|---|---|---|---|
CD274 | RNA | Single gene | Programmed death 1 ligand 1 | [21] |
Mutational load | DNA | Nr. mutations | Absolute number of mutations in WES | |
IFN-y (reduced set) | RNA | Gene set | Interferon gamma reduced set | [9] |
IFN-y (expanded set) | RNA | Gene set | Interferon gamma reduced set | [9] |
IPS | RNA | Algorithm | Immunophenoscore | [6] |
PDCD1 | RNA | Single gene | Programmed death 1 | [23] |
POLE | RNA | Single gene | DNA polymerase epsilon, catalytic subunit | [11] |
POLE2 | RNA | Single gene | DNA polymerase epsilon 2, accessory subunit | [11] |
POLE3 | RNA | Single gene | DNA polymerase epsilon 3, accessory subunit | [11] |
POLE4 | RNA | Single gene | DNA polymerase epsilon 4, accessory subunit | [11] |
CTLA4 | RNA | Single gene | Cytotoxic T-lymphocyte associated protein 4 | [25] |
PDCD1LG2 | RNA | Single gene | Programmed cell death 1 ligand 2 | [24] |
ICB resist. signature 1 | RNA | Gene set | Epithelial–mesenchymal transition signature 1 | [7] |
ICB resist. signature 2 | RNA | Gene set | Epithelial–mesenchymal transition signature 2 | [17] |
ICB resist. signature 3 | RNA | Gene set | Epithelial–mesenchymal transition signature 3 | [18] |
AXL pathway | RNA | Gene set | AXL receptor tyrosine kinase pathway | [19] |
AXL | RNA | Single gene | AXL receptor tyrosine kinase | [19] |
TIDE | RNA | Algorithm | Tumor immune dysfunction and exclusion | [12] |