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Table 2 List of biomarkers in this study

From: Combinations of immuno-checkpoint inhibitors predictive biomarkers only marginally improve their individual accuracy

Marker Origin Type Description References
CD274 RNA Single gene Programmed death 1 ligand 1 [21]
Mutational load DNA Nr. mutations Absolute number of mutations in WES [8, 22]
IFN-y (reduced set) RNA Gene set Interferon gamma reduced set [9]
IFN-y (expanded set) RNA Gene set Interferon gamma reduced set [9]
IPS RNA Algorithm Immunophenoscore [6]
PDCD1 RNA Single gene Programmed death 1 [23]
POLE RNA Single gene DNA polymerase epsilon, catalytic subunit [11]
POLE2 RNA Single gene DNA polymerase epsilon 2, accessory subunit [11]
POLE3 RNA Single gene DNA polymerase epsilon 3, accessory subunit [11]
POLE4 RNA Single gene DNA polymerase epsilon 4, accessory subunit [11]
CTLA4 RNA Single gene Cytotoxic T-lymphocyte associated protein 4 [25]
PDCD1LG2 RNA Single gene Programmed cell death 1 ligand 2 [24]
ICB resist. signature 1 RNA Gene set Epithelial–mesenchymal transition signature 1 [7]
ICB resist. signature 2 RNA Gene set Epithelial–mesenchymal transition signature 2 [17]
ICB resist. signature 3 RNA Gene set Epithelial–mesenchymal transition signature 3 [18]
AXL pathway RNA Gene set AXL receptor tyrosine kinase pathway [19]
AXL RNA Single gene AXL receptor tyrosine kinase [19]
TIDE RNA Algorithm Tumor immune dysfunction and exclusion [12]