Fig. 5

Exogenous FNDC5 pretreatment attenuated palmitate-induced inflammation and oxidative stress in CMs. a, b Effects of exogenous FNDC5 pretreatment on cardiac hypertrophy markers (Nppa, Nppb and Myh7) and inflammation markers (Tnf-α, Il1b and Il6) mRNA levels in PA-stimulated CMs. c Effects of exogenous FNDC5 pretreatment on NO production in cell culture supernatant of PA-stimulated CMs. d Effects of exogenous FNDC5 pretreatment on NOX expression in PA-stimulated CMs. PA: Palmitate; Veh: Vehicle. Values are mean ± SEM. *P < 0.05 vs. Veh. ^†P < 0.05 vs. PA. n = 6